Protein: S4A4
Electrogenic sodium bicarbonate cotransporter 1 (Sodium bicarbonate cotransporter) (Na(+)/HCO3(-) cotransporter) (Solute carrier family 4 member 4) (kNBC1)

Gene: S4A4, SLC4A4
Organism: Homo sapiens
Interactions: 61
UniProt ID: Q9Y6R1

Gene Ontology (top 5):
GO:0005452 - solute:inorganic anion antiporter activity
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0006814 - sodium ion transport
GO:0008509 - monoatomic anion transmembrane transporter activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1491861

S4A4
Electrogenic sodium bicarbonate cotransporter 1

1

9

Small-scale

0.618

High

1180876

S4A8
Electroneutral sodium bicarbonate exchanger 1

1

9

High-throughput

0.575

High

930832

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

2

6

High-throughput

0.571

High

1095495

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

2

6

High-throughput

0.571

High

1085495

SRBP2
Sterol regulatory element-binding protein 2

1

1

High-throughput

0.541

High

106945

APRIO
Alternative prion protein

2

2

High-throughput

0.533

High

598244

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

4

High-throughput

0.515

High

243455

PRKN
E3 ubiquitin-protein ligase parkin

1

2

High-throughput

0.479

High

376166

RASK
GTPase KRas

1

12

High-throughput

0.479

High

652636

CAH4
Carbonic anhydrase 4

1

5

Small-scale

0.479

High

1122386

SCRIB
Protein scribble homolog

1

3

Small-scale

0.479

High

1047500

K1C17
Keratin, type I cytoskeletal 17

1

0

High-throughput

0.458

High

1114796

CUL3
Cullin-3

1

0

High-throughput

0.458

High

134933

SAP18
Histone deacetylase complex subunit SAP18

1

1

High-throughput

0.445

High

136457

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

6

High-throughput

0.445

High

225739

AAKB2
5'-AMP-activated protein kinase subunit beta-2

1

3

High-throughput

0.445

High

230145

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

8

High-throughput

0.445

High

323810

AP2A2
AP-2 complex subunit alpha-2

1

2

High-throughput

0.445

High

344840

AP2A1
AP-2 complex subunit alpha-1

1

2

High-throughput

0.445

High

404973

PRIO
Major prion protein

1

1

High-throughput

0.445

High

530686

TAU
Microtubule-associated protein tau

1

2

High-throughput

0.445

High

611440

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

7

High-throughput

0.445

High

625737

CSK22
Casein kinase II subunit alpha'

1

1

High-throughput

0.445

High

920412

PLK1
Serine/threonine-protein kinase PLK1

1

2

High-throughput

0.445

High

930389

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

1

3

High-throughput

0.445

High

989184

AP2B1
AP-2 complex subunit beta

1

3

High-throughput

0.445

High

998143

CSK21
Casein kinase II subunit alpha

1

1

High-throughput

0.445

High

1036824

DSG1
Desmoglein-1

1

4

High-throughput

0.445

High

1119413

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

1

High-throughput

0.445

High

1145462

RNPS1
RNA-binding protein with serine-rich domain 1

1

1

High-throughput

0.445

High

1293360

CHSS1
Chondroitin sulfate synthase 1

1

3

High-throughput

0.445

High

1295737

HORN
Hornerin

1

1

High-throughput

0.445

High

1328018

CISD2
CDGSH iron-sulfur domain-containing protein 2

1

1

High-throughput

0.445

High

1330272

ARF
Tumor suppressor ARF

1

1

High-throughput

0.445

High

1393339

SAHH3
Adenosylhomocysteinase 3

1

8

High-throughput

0.445

High

1396715

B3GT6
Beta-1,3-galactosyltransferase 6

1

1

High-throughput

0.445

High

1432405

PININ
Pinin

1

1

High-throughput

0.445

High

1445765

WDR6
tRNA

1

6

High-throughput

0.445

High

1454514

CHPF2
Chondroitin sulfate glucuronyltransferase

1

3

High-throughput

0.445

High

1459556

AAKG2
5'-AMP-activated protein kinase subunit gamma-2

1

3

High-throughput

0.445

High

1490737

FND3A
Fibronectin type-III domain-containing protein 3A

1

3

High-throughput

0.445

High

1491338

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

3

High-throughput

0.445

High

1256325

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

370383

CYTA
Cystatin-A

1

0

High-throughput

0.426

High

390235

ALBU
Albumin

1

0

High-throughput

0.426

High

995375

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.426

High

1034094

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

0

High-throughput

0.426

High

1152320

MARE1
Microtubule-associated protein RP/EB family member 1

1

0

High-throughput

0.426

High

1199781

KLH22
Kelch-like protein 22

1

0

High-throughput

0.426

High

1213866

KPRP
Keratinocyte proline-rich protein

1

0

High-throughput

0.426

High

1286316

GALT7
N-acetylgalactosaminyltransferase 7

1

0

High-throughput

0.426

High

1386763

AP2M1
AP-2 complex subunit mu

1

0

High-throughput

0.426

High

171045

CLGN
Calmegin

1

6

High-throughput

0.407

High

1204049

FILA2
Filaggrin-2

1

1

High-throughput

0.407

High

1313959

KBTB2
Kelch repeat and BTB domain-containing protein 2

1

3

High-throughput

0.407

High

1452987

CISD1
CDGSH iron-sulfur domain-containing protein 1

1

1

High-throughput

0.407

High

1461967

EPDR1
Mammalian ependymin-related protein 1

1

1

High-throughput

0.407

High

1462672

SRRM2
Serine/arginine repetitive matrix protein 2

1

1

High-throughput

0.407

High

215737

COCH
Cochlin

1

0

High-throughput

0.232

Low

270067

XYLK
Glycosaminoglycan xylosylkinase

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025