HitPredict

Interactor 1: E4F1 (Q66K89)
Transcription factor E4F1 (EC 2.3.2.27) (E4F transcription factor 1) (Putative E3 ubiquitin-protein ligase E4F1) (RING-type E3 ubiquitin transferase E4F1) (Transcription factor E4F) (p120E4F) (p50E4F)
Gene: E4F1

Interactor 2: Q6IT96 (Q6IT96)
Histone deacetylase (EC 3.5.1.98)
Gene: HDAC1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	21666599
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005654 - nucleoplasm GO:0046872 - metal ion binding
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 784 Hs			1 482
+	Hs
		1038459 E4F1_HUMAN (1-784): 0: 590: 100.00		HDAC1_HUMAN (1-482): 0: 668: 100.00
+	Dr
		1118809 E4F1_DANRE (24-784): 0: 575: 45.37		Q8JIY7_DANRE (4-481): 0: 646: 90.17
+	Mm
		140207 GFI1B_MOUSE (192-266): 5.16e-10: 63.5: 36.00		HDAC1_MOUSE (1-482): 0: 672: 99.38
+	Hs
		1038663 GFI1_HUMAN (169-267): 2.44e-09: 62.4: 37.00		HDAC1_HUMAN (1-482): 0: 668: 100.00
+	Hs
		1138065 GFI1B_HUMAN (192-266): 2.9e-10: 64.3: 36.00		HDAC2_HUMAN (1-478): 0: 666: 85.92
+	Hs
		1270404 GFI1_HUMAN (169-267): 2.44e-09: 62.4: 37.00		HDAC2_HUMAN (1-478): 0: 666: 85.92
+	Mm
		250551 GFI1B_MOUSE (192-266): 5.16e-10: 63.5: 36.00		HDAC2_MOUSE (1-478): 0: 664: 85.71