HitPredict

Interactor 1: DTLB (Q6GPU3)
Denticleless protein homolog B
Gene: dtl-b

Interactor 2: DDB1 (Q6P6Z0)
DNA damage-binding protein 1 (Damage-specific DNA-binding protein 1)
Gene: DDB1

Species: Xenopus laevis

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	16949367, 20606006
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	CPSF_A~WD40, MMS1_N~WD40
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0031464 - Cul4A-RING E3 ubiquitin ligase complex GO:0031465 - Cul4B-RING E3 ubiquitin ligase complex GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process and 1 others more... GO:0048511 - rhythmic process
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 711 Xl			1 1140
+	Hs
		1082431 DTL_HUMAN (1-711): 2.15e-116: 368: 52.64		DDB1_HUMAN (1-1140): 0: 1399: 93.42
+	Hs
		1016284 TBL3_HUMAN (17-546): 2.2e-79: 271: 12.01		DDB1_HUMAN (1-1140): 0: 1399: 93.42
+	Hs
		560882 GBB3_HUMAN (171-513): 4.66e-49: 177: 9.28		DDB1_HUMAN (1-1140): 0: 1399: 93.42
+	Hs
		245605 TBL1X_HUMAN (182-513): 6.5e-46: 174: 13.10		DDB1_HUMAN (1-1140): 0: 1399: 93.42
+	Hs
		1082374 TBL1R_HUMAN (191-485): 1.47e-38: 152: 13.47		DDB1_HUMAN (1-1140): 0: 1399: 93.42
+	Hs
		1082263 WDR5B_HUMAN (302-505): 6.71e-37: 142: 17.65		DDB1_HUMAN (1-1140): 0: 1399: 93.42
+	Hs
		903254 WDR5_HUMAN (2-168): 1.42e-36: 142: 14.13		DDB1_HUMAN (1-1140): 0: 1399: 93.42
+	Hs
		1082327 SNR40_HUMAN (269-438): 2.63e-28: 118: 18.82		DDB1_HUMAN (1-1140): 0: 1399: 93.42
+	Dm
		1097651 L2DTL_DROME (9-246): 1.01e-23: 108: 11.18		DDB1_DROME (1-1140): 0: 1221: 60.66
+	Hs
		1073168 NLE1_HUMAN (167-593): 5.61e-50: 184: 13.83		SF3B3_HUMAN (3-1136): 0: 1078: 21.59
+	Ce
		1094296 Q22059_CAEEL (48-657): 2.06e-68: 239: 19.73		DDB1_CAEEL (1-1140): 0: 1013: 37.30
+	Hs
		267761 TAF5L_HUMAN (64-171): 3.24e-09: 62: 32.41		SF3B3_HUMAN (3-1136): 0: 1078: 21.59
+	Sp
		143275 CDT2_SCHPO (52-414): 5.45e-80: 265: 24.68		DDB1_SCHPO (5-1140): 0: 817: 24.37
+	Sp
		195202 PRP17_SCHPO (4-300): 2.51e-23: 106: 12.22		RSE1_SCHPO (3-1136): 0: 923: 20.57
+	Sc
		778636 PRP17_YEAST (86-388): 1.23e-61: 215: 19.87		RSE1_YEAST (3-1136): 0: 687: 15.60
+	Hs
		1014208 NLE1_HUMAN (167-593): 5.61e-50: 184: 13.83		CPSF1_HUMAN (638-1133): 1.54e-118: 401: 20.15