Protein: DHX16
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 (EC 3.6.4.13) (ATP-dependent RNA helicase #3) (DEAH-box protein 16)

Gene: DHX16
Organism: Homo sapiens
Interactions: 146
UniProt ID: O60231

Gene Ontology (top 5):
GO:0000398 - mRNA splicing, via spliceosome
GO:0003723 - RNA binding
GO:0003724 - RNA helicase activity
GO:0004386 - helicase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

238931

GPKOW
G-patch domain and KOW motifs-containing protein

5

3

Small-scale

0.938

High

238928

PRP16
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

2

15

High-throughput

0.808

High

238923

TTC29
Tetratricopeptide repeat protein 29

2

0

High-throughput

0.748

High

238844

RIGI
Antiviral innate immune response receptor RIG-I

1

13

Small-scale

0.724

High

238957

ANLN
Anillin

3

3

High-throughput

0.656

High

238858

TOP2A
DNA topoisomerase 2-alpha

1

0

High-throughput

0.631

High

238942

SETB2
Histone-lysine N-methyltransferase SETDB2

2

3

High-throughput

0.628

High

238964

TFP11
Tuftelin-interacting protein 11

1

8

High-throughput

0.621

High

238870

RECQ1
ATP-dependent DNA helicase Q1

1

11

High-throughput

0.618

High

238897

DHX8
ATP-dependent RNA helicase DHX8

1

15

High-throughput

0.618

High

238914

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.618

High

238918

DHX40
Probable ATP-dependent RNA helicase DHX40

1

14

High-throughput

0.618

High

238932

FBXW7
F-box/WD repeat-containing protein 7

1

4

High-throughput

0.618

High

238935

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

8

High-throughput

0.618

High

238947

DDX23
Probable ATP-dependent RNA helicase DDX23

1

11

High-throughput

0.618

High

238950

TRIM6
Tripartite motif-containing protein 6

1

1

Small-scale

0.618

High

238869

COIL
Coilin

2

3

High-throughput

0.614

High

238841

CDKL5
Cyclin-dependent kinase-like 5

2

5

High-throughput

0.611

High

238924

SERB1
SERPINE1 mRNA-binding protein 1

2

4

High-throughput

0.611

High

238838

BRD4
Bromodomain-containing protein 4

2

14

High-throughput

0.584

High

238926

PPIL4
Peptidyl-prolyl cis-trans isomerase-like 4

2

5

High-throughput

0.584

High

238893

SF3B2
Splicing factor 3B subunit 2

1

2

High-throughput

0.573

High

238955

SYF1
Pre-mRNA-splicing factor SYF1

1

17

High-throughput

0.573

High

238856

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

4

Small-scale

0.561

High

238882

CSK21
Casein kinase II subunit alpha

1

4

High-throughput

0.550

High

238837

ANM3
Protein arginine N-methyltransferase 3

1

3

High-throughput

0.536

High

238854

RU1C
U1 small nuclear ribonucleoprotein C

1

1

High-throughput

0.536

High

238857

TOP1
DNA topoisomerase 1

1

1

High-throughput

0.536

High

238865

FOXN2
Forkhead box protein N2

1

4

High-throughput

0.536

High

238866

BMI1
Polycomb complex protein BMI-1

1

4

High-throughput

0.536

High

238875

JAK3
Tyrosine-protein kinase JAK3

1

4

High-throughput

0.536

High

238876

FOXL2
Forkhead box protein L2

1

3

High-throughput

0.536

High

238879

RL31
Large ribosomal subunit protein eL31

1

3

High-throughput

0.536

High

238880

SUMO1
Small ubiquitin-related modifier 1

1

2

High-throughput

0.536

High

238883

SERF2
Small EDRK-rich factor 2

1

1

High-throughput

0.536

High

238888

KPCD
Protein kinase C delta type

1

2

High-throughput

0.536

High

238891

SRSF6
Serine/arginine-rich splicing factor 6

1

8

High-throughput

0.536

High

238895

NOG2
Nucleolar GTP-binding protein 2

1

4

High-throughput

0.536

High

238899

RNPS1
RNA-binding protein with serine-rich domain 1

1

11

High-throughput

0.536

High

238900

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

6

High-throughput

0.536

High

238905

LBH
Protein LBH

1

1

High-throughput

0.536

High

238916

CD20B
Cell division cycle protein 20 homolog B

1

7

High-throughput

0.536

High

238921

TXLNB
Beta-taxilin

1

6

High-throughput

0.536

High

238930

EZH1
Histone-lysine N-methyltransferase EZH1

1

5

High-throughput

0.536

High

238940

BIRC8
Baculoviral IAP repeat-containing protein 8

1

4

High-throughput

0.536

High

238941

NUDC1
NudC domain-containing protein 1

1

6

High-throughput

0.536

High

238951

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

4

High-throughput

0.536

High

238868

DEK
Protein DEK

1

1

High-throughput

0.515

High

217019

MS18B
Protein Mis18-beta

1

0

High-throughput

0.513

High

238848

FRIH
Ferritin heavy chain

1

0

High-throughput

0.513

High

238896

BLMH
Bleomycin hydrolase

1

0

High-throughput

0.513

High

238904

AKIR2
Akirin-2

1

0

High-throughput

0.513

High

238908

ZFY27
Protrudin

1

0

High-throughput

0.513

High

238910

LEG9C
Galectin-9C

1

0

High-throughput

0.513

High

238912

CPLX2
Complexin-2

1

0

High-throughput

0.513

High

238933

I27L1
Interferon alpha-inducible protein 27-like protein 1

1

0

High-throughput

0.513

High

238938

AJUBA
LIM domain-containing protein ajuba

1

0

High-throughput

0.513

High

238946

TCAL7
Transcription elongation factor A protein-like 7

1

0

High-throughput

0.513

High

238954

CSR2B
Cysteine-rich protein 2-binding protein

1

0

High-throughput

0.513

High

238967

FBX5
F-box only protein 5

1

0

High-throughput

0.513

High

238970

POLH
DNA polymerase eta

1

0

High-throughput

0.513

High

238973

MB212
Protein mab-21-like 2

1

0

High-throughput

0.513

High

238934

ESS2
Splicing factor ESS-2 homolog

1

2

High-throughput

0.508

High

238913

GTR7
Solute carrier family 2, facilitated glucose transporter member 7

1

1

High-throughput

0.489

High

238963

PEN2
Gamma-secretase subunit PEN-2

1

1

High-throughput

0.489

High

238917

HOMEZ
Homeobox and leucine zipper protein Homez

1

1

High-throughput

0.481

High

238936

MYO19
Unconventional myosin-XIX

1

1

High-throughput

0.481

High

238852

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

140673

NOP56
Nucleolar protein 56

1

4

High-throughput

0.479

High

156737

CTRO
Citron Rho-interacting kinase

1

5

High-throughput

0.479

High

172303

XPO1
Exportin-1

1

4

High-throughput

0.479

High

190748

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

4

High-throughput

0.479

High

238835

PRKN
E3 ubiquitin-protein ligase parkin

1

7

High-throughput

0.479

High

238839

OBSL1
Obscurin-like protein 1

1

4

High-throughput

0.479

High

238840

TAD2A
Transcriptional adapter 2-alpha

1

3

High-throughput

0.479

High

238843

KI20A
Kinesin-like protein KIF20A

1

7

High-throughput

0.479

High

238845

EGFR
Epidermal growth factor receptor

1

1

High-throughput

0.479

High

238846

MYC
Myc proto-oncogene protein

1

6

High-throughput

0.479

High

238847

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

7

High-throughput

0.479

High

238849

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

3

High-throughput

0.479

High

238850

NTRK1
High affinity nerve growth factor receptor

1

5

High-throughput

0.479

High

238851

P53
Cellular tumor antigen p53

1

3

High-throughput

0.479

High

238855

PARP1
Poly [ADP-ribose] polymerase 1

1

3

High-throughput

0.479

High

238859

XRCC6
X-ray repair cross-complementing protein 6

1

3

High-throughput

0.479

High

238860

RFA2
Replication protein A 32 kDa subunit

1

6

High-throughput

0.479

High

238862

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

238864

DPOD1
DNA polymerase delta catalytic subunit

1

1

High-throughput

0.479

High

238867

RFA3
Replication protein A 14 kDa subunit

1

6

High-throughput

0.479

High

238872

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

2

High-throughput

0.479

High

238873

MECP2
Methyl-CpG-binding protein 2

1

4

High-throughput

0.479

High

238877

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

5

High-throughput

0.479

High

238878

H2B1C
Histone H2B type 1-C/E/F/G/I

1

7

High-throughput

0.479

High

238881

ACTC
Actin, alpha cardiac muscle 1

1

2

High-throughput

0.479

High

238884

H33
Histone H3.3

1

4

High-throughput

0.479

High

238885

VIGLN
Vigilin

1

3

High-throughput

0.479

High

238886

KIF23
Kinesin-like protein KIF23

1

3

High-throughput

0.479

High

238889

EP300
Histone acetyltransferase p300

1

11

High-throughput

0.479

High

238890

CBX3
Chromobox protein homolog 3

1

4

High-throughput

0.479

High

238892

TIF1B
Transcription intermediary factor 1-beta

1

9

High-throughput

0.479

High

238894

BIRC3
Baculoviral IAP repeat-containing protein 3

1

4

High-throughput

0.479

High

238898

CUL7
Cullin-7

1

2

High-throughput

0.479

High

238901

IF16
Gamma-interferon-inducible protein 16

1

6

High-throughput

0.479

High

238906

HABP4
Intracellular hyaluronan-binding protein 4

1

4

High-throughput

0.479

High

238911

IFIX
Pyrin and HIN domain-containing protein 1

1

6

High-throughput

0.479

High

238915

MAVS
Mitochondrial antiviral-signaling protein

1

3

Small-scale

0.479

High

238919

SLX4
Structure-specific endonuclease subunit SLX4

1

4

High-throughput

0.479

High

238920

SRRM1
Serine/arginine repetitive matrix protein 1

1

3

High-throughput

0.479

High

238927

TOPB1
DNA topoisomerase 2-binding protein 1

1

4

High-throughput

0.479

High

238937

DDRGK
DDRGK domain-containing protein 1

1

3

High-throughput

0.479

High

238943

CDC5L
Cell division cycle 5-like protein

1

11

High-throughput

0.479

High

238948

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

4

High-throughput

0.479

High

238953

PKHA4
Pleckstrin homology domain-containing family A member 4

1

6

High-throughput

0.479

High

238956

BRD7
Bromodomain-containing protein 7

1

12

High-throughput

0.479

High

238958

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

5

High-throughput

0.479

High

238960

ARGL1
Arginine and glutamate-rich protein 1

1

3

High-throughput

0.479

High

238961

AATF
Protein AATF

1

1

High-throughput

0.479

High

238962

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

2

High-throughput

0.479

High

238965

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

238968

NUP50
Nuclear pore complex protein Nup50

1

3

High-throughput

0.479

High

238969

SRRM2
Serine/arginine repetitive matrix protein 2

1

4

High-throughput

0.479

High

238972

ZN330
Zinc finger protein 330

1

1

High-throughput

0.479

High

238939

MEG10
Multiple epidermal growth factor-like domains protein 10

1

2

Small-scale

0.464

High

238929

APBP2
Amyloid protein-binding protein 2

1

0

High-throughput

0.460

High

238863

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

High-throughput

0.458

High

238887

TF65
Transcription factor p65

1

0

High-throughput

0.458

High

238944

CTIP
DNA endonuclease RBBP8

1

0

Small-scale

0.458

High

238959

DISC1
Disrupted in schizophrenia 1 protein

1

1

High-throughput

0.457

High

238966

TNIK
TRAF2 and NCK-interacting protein kinase

1

1

High-throughput

0.457

High

238853

JUN
Transcription factor Jun

1

5

High-throughput

0.445

High

238903

NCBP3
Nuclear cap-binding protein subunit 3

1

2

High-throughput

0.445

High

238907

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

4

High-throughput

0.445

High

238925

ARK74
Aflatoxin B1 aldehyde reductase member 4

1

2

High-throughput

0.445

High

238842

RHBT1
Rho-related BTB domain-containing protein 1

1

2

High-throughput

0.437

High

238945

LZTS2
Leucine zipper putative tumor suppressor 2

1

8

High-throughput

0.437

High

238952

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

7

High-throughput

0.437

High

238861

VCAM1
Vascular cell adhesion protein 1

1

2

High-throughput

0.407

High

238871

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.279

Low

238909

CP141
Cilia- and flagella-associated protein 141

1

0

High-throughput

0.279

Low

238922

CMIP6
Ciliary microtubule inner protein 6

1

0

High-throughput

0.279

Low

238971

AP3M1
AP-3 complex subunit mu-1

1

0

High-throughput

0.279

Low

238974

FADS3
Fatty acid desaturase 3

1

0

High-throughput

0.279

Low

238975

SPCS1
Signal peptidase complex subunit 1

1

0

High-throughput

0.279

Low

238836

PLOD3
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3

1

0

High-throughput

0.269

Low

238874

DHB4
Peroxisomal multifunctional enzyme type 2

1

0

High-throughput

0.269

Low

238902

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low

238949

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025