HitPredict

Interactor 1: LTOR1 (Q6IAA8)
Ragulator complex protein LAMTOR1 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1) (Lipid raft adaptor protein p18) (Protein associated with DRMs and endosomes) (p27Kip1-releasing factor from RhoA) (p27RF-Rho)
Gene: LAMTOR1

Interactor 2: PKHM1 (Q9Y4G2)
Pleckstrin homology domain-containing family M member 1 (PH domain-containing family M member 1) (162 kDa adapter protein) (AP162)
Gene: PLEKHM1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	34079125, 33452816
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005764 - lysosome GO:0031902 - late endosome membrane GO:0032418 - lysosome localization
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 161 Hs			1 1056
+	Hs
		1151923 LTOR1_HUMAN (1-161): 1.93e-90: 262: 100.00		PKHM3_HUMAN (406-1055): 0: 811: 28.33
+	Hs
		1151926 LTOR1_HUMAN (1-161): 1.93e-90: 262: 100.00		RUFY3_HUMAN (15-334): 1.28e-80: 272: 18.90
+	Hs
		1152069 LTOR1_HUMAN (1-161): 1.93e-90: 262: 100.00		FYCO1_HUMAN (12-397): 5.7e-66: 245: 12.19
+	Hs
		1152053 LTOR1_HUMAN (1-161): 1.93e-90: 262: 100.00		RUFY1_HUMAN (13-506): 8.59e-67: 240: 18.15
+	Hs
		1152006 LTOR1_HUMAN (1-161): 1.93e-90: 262: 100.00		RUFY2_HUMAN (10-519): 1.02e-66: 238: 13.74
+	Hs
		1151998 LTOR1_HUMAN (1-161): 1.93e-90: 262: 100.00		SNX29_HUMAN (7-492): 8.21e-57: 213: 17.42
+	Hs
		1151949 LTOR1_HUMAN (1-161): 1.93e-90: 262: 100.00		PKHM2_HUMAN (9-516): 2.75e-55: 210: 19.22
+	Hs
		1151919 LTOR1_HUMAN (1-161): 1.93e-90: 262: 100.00		DEN5B_HUMAN (12-210): 2.2e-48: 190: 21.56