HitPredict

Interactor 1: NEDD8 (Q15843)
Ubiquitin-like protein NEDD8 (Neddylin) (Neural precursor cell expressed developmentally down-regulated protein 8) (NEDD-8)
Gene: NEDD8

Interactor 2: CSN5 (Q92905)
COP9 signalosome complex subunit 5 (SGN5) (Signalosome subunit 5) (EC 3.4.-.-) (Jun activation domain-binding protein 1)
Gene: COPS5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.926

Property	Details
Experiments	25144743, 19615732, 21145461, 34642328, 16503656
Identification Methods	pull down, affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	JAB~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006508 - proteolysis and 1 others more... GO:0045116 - protein neddylation
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 81 Hs			1 334
+	Hs
		138057 RS27A_HUMAN (1-77): 6.68e-37: 122: 57.14		PSDE_HUMAN (50-331): 1.68e-79: 246: 31.51
+	Hs
		138058 RL40_HUMAN (1-76): 3.81e-33: 112: 57.90		PSDE_HUMAN (50-331): 1.68e-79: 246: 31.51
+	Hs
		137924 UBB_HUMAN (1-76): 2.41e-30: 107: 57.90		PSDE_HUMAN (50-331): 1.68e-79: 246: 31.51
+	Sc
		850187 RUB1_YEAST (1-76): 1.46e-21: 81.3: 59.21		RPN11_YEAST (39-333): 9.62e-75: 234: 29.14
+	Hs
		507110 UBB_HUMAN (1-76): 2.41e-30: 107: 57.90		BRCC3_HUMAN (56-203): 4.63e-43: 152: 21.23