Protein: BRCC3
Lys-63-specific deubiquitinase BRCC36 (EC 3.4.19.-) (BRCA1-A complex subunit BRCC36) (BRCA1/BRCA2-containing complex subunit 3) (BRCA1/BRCA2-containing complex subunit 36) (BRISC complex subunit BRCC36)

Gene: BRCC3
Organism: Homo sapiens
Interactions: 100
UniProt ID: P46736

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0000152 - nuclear ubiquitin ligase complex
GO:0000922 - spindle pole
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

858774

ABRX2
BRISC complex subunit Abraxas 2

14

3

Small-scale

0.981

High

858782

ABRX1
BRCA1-A complex subunit Abraxas 1

11

3

Small-scale

0.979

High

507662

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

8

12

Small-scale

0.965

High

858812

BABA2
BRISC and BRCA1-A complex member 2

11

1

Small-scale

0.758

High

798819

BRCA1
Breast cancer type 1 susceptibility protein

9

4

Small-scale

0.750

High

858801

UIMC1
BRCA1-A complex subunit RAP80

13

0

Small-scale

0.728

High

858811

BABA1
BRISC and BRCA1-A complex member 1

10

0

Small-scale

0.722

High

858800

NLRP3
NACHT, LRR and PYD domains-containing protein 3

5

4

Small-scale

0.702

High

760872

GLYM
Serine hydroxymethyltransferase, mitochondrial

4

1

Small-scale

0.699

High

858790

UBL4B
Ubiquitin-like protein 4B

1

9

High-throughput

0.691

High

858808

DEFI6
Differentially expressed in FDCP 6 homolog

3

5

High-throughput

0.667

High

131804

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

3

4

Small-scale

0.664

High

858803

BARD1
BRCA1-associated RING domain protein 1

3

5

Small-scale

0.650

High

507110

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

12

Small-scale

0.618

High

858752

BRCC3
Lys-63-specific deubiquitinase BRCC36

1

8

Small-scale

0.618

High

858770

CUL3
Cullin-3

1

12

High-throughput

0.618

High

858793

CSN5
COP9 signalosome complex subunit 5

1

16

Small-scale

0.618

High

413377

P53
Cellular tumor antigen p53

2

2

Small-scale

0.606

High

603626

JUNB
Transcription factor JunB

2

5

High-throughput

0.601

High

858756

BRCA2
Breast cancer type 2 susceptibility protein

2

0

Small-scale

0.595

High

858759

SUMO2
Small ubiquitin-related modifier 2

2

1

Small-scale

0.595

High

858778

TFDP3
Transcription factor Dp family member 3

2

0

High-throughput

0.585

High

858772

MDC1
Mediator of DNA damage checkpoint protein 1

2

7

High-throughput

0.584

High

503559

TFPT
TCF3 fusion partner

2

0

High-throughput

0.576

High

856578

BAG6
Large proline-rich protein BAG6

1

10

High-throughput

0.575

High

711276

SHC1
SHC-transforming protein 1

2

3

High-throughput

0.571

High

858799

CI085
Uncharacterized protein C9orf85

2

1

High-throughput

0.549

High

858813

UVRAG
UV radiation resistance-associated gene protein

2

0

Small-scale

0.547

High

166504

BACH1
Transcription regulator protein BACH1

1

11

High-throughput

0.541

High

858776

ITSN1
Intersectin-1

1

4

High-throughput

0.541

High

185172

FANCG
Fanconi anemia group G protein

1

0

Small-scale

0.537

High

858773

NUMA1
Nuclear mitotic apparatus protein 1

1

5

Small-scale

0.536

High

354845

DNAL4
Dynein axonemal light chain 4

1

2

High-throughput

0.536

High

858753

ATPO
ATP synthase peripheral stalk subunit OSCP, mitochondrial

1

1

High-throughput

0.536

High

858755

MCM2
DNA replication licensing factor MCM2

1

4

High-throughput

0.536

High

858760

1433G
14-3-3 protein gamma

1

6

High-throughput

0.536

High

858766

1433F
14-3-3 protein eta

1

6

High-throughput

0.536

High

858786

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

7

High-throughput

0.536

High

858794

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

3

High-throughput

0.536

High

858795

RN166
E3 ubiquitin-protein ligase RNF166

1

4

High-throughput

0.536

High

858810

TENS1
Tensin-1

1

3

High-throughput

0.536

High

858817

SP16H
FACT complex subunit SPT16

1

3

High-throughput

0.536

High

299818

SNPC5
snRNA-activating protein complex subunit 5

1

0

High-throughput

0.518

High

333636

NDUAA
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

1

0

High-throughput

0.513

High

858754

CENPA
Histone H3-like centromeric protein A

1

0

High-throughput

0.513

High

858767

RAD51
DNA repair protein RAD51 homolog 1

1

0

Small-scale

0.513

High

858788

EXOC8
Exocyst complex component 8

1

0

High-throughput

0.513

High

858757

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

2

Small-scale

0.501

High

858807

DJC25
DnaJ homolog subfamily C member 25

1

1

High-throughput

0.489

High

697350

CD82
CD82 antigen

1

1

Small-scale

0.481

High

858781

ANR11
Ankyrin repeat domain-containing protein 11

1

6

High-throughput

0.481

High

170004

AURKA
Aurora kinase A

1

1

Small-scale

0.479

High

217942

TGON2
Trans-Golgi network integral membrane protein 2

1

3

High-throughput

0.479

High

315249

RECQ4
ATP-dependent DNA helicase Q4

1

11

High-throughput

0.479

High

349858

SNAI1
Zinc finger protein SNAI1

1

3

Small-scale

0.479

High

400455

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

588138

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

651216

CBL
E3 ubiquitin-protein ligase CBL

1

1

High-throughput

0.479

High

713937

PML
Protein PML

1

5

High-throughput

0.479

High

764525

CTNB1
Catenin beta-1

1

7

Small-scale

0.479

High

767636

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

786433

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

2

High-throughput

0.479

High

858758

TERA
Transitional endoplasmic reticulum ATPase

1

5

High-throughput

0.479

High

858761

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

858762

H4
Histone H4

1

2

High-throughput

0.479

High

858763

GRB2
Growth factor receptor-bound protein 2

1

4

High-throughput

0.479

High

858764

CDK5
Cyclin-dependent kinase 5

1

6

Small-scale

0.479

High

858768

TP53B
TP53-binding protein 1

1

7

High-throughput

0.479

High

858769

SQSTM
Sequestosome-1

1

2

High-throughput

0.479

High

858771

TRI14
Tripartite motif-containing protein 14

1

4

High-throughput

0.479

High

858775

E2F5
Transcription factor E2F5

1

2

High-throughput

0.479

High

858780

TENS2
Tensin-2

1

2

High-throughput

0.479

High

858783

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.479

High

858784

PAXI1
PAX-interacting protein 1

1

4

High-throughput

0.479

High

858785

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

858787

TRI50
E3 ubiquitin-protein ligase TRIM50

1

2

Small-scale

0.479

High

858792

ESR2
Estrogen receptor beta

1

6

High-throughput

0.479

High

858797

SNX27
Sorting nexin-27

1

7

High-throughput

0.479

High

858798

CI072
Guanine nucleotide exchange factor C9orf72

1

2

High-throughput

0.479

High

858802

CRBN
Protein cereblon

1

1

Small-scale

0.479

High

858804

FANCJ
Fanconi anemia group J protein

1

1

Small-scale

0.479

High

858806

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

5

Small-scale

0.479

High

858809

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

858814

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

858815

HERC5
E3 ISG15--protein ligase HERC5

1

7

Small-scale

0.479

High

858818

X5D778
Ankyrin repeat domain 11 isoform A

1

6

High-throughput

0.470

High

187485

FANCA
Fanconi anemia group A protein

1

0

Small-scale

0.458

High

858796

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

0

High-throughput

0.458

High

602881

INAR1
Interferon alpha/beta receptor 1

1

3

Small-scale

0.457

High

858816

TNIK
TRAF2 and NCK-interacting protein kinase

1

5

High-throughput

0.457

High

91884

C9JYE9
E2F transcription factor 5

1

2

High-throughput

0.445

High

858777

ODFP2
Outer dense fiber protein 2

1

4

High-throughput

0.445

High

858791

ZNT7
Zinc transporter 7

1

4

High-throughput

0.445

High

858779

LRC73
Leucine-rich repeat-containing protein 73

1

5

High-throughput

0.407

High

813024

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

0

High-throughput

0.279

Low

858789

CMIP6
Ciliary microtubule inner protein 6

1

0

High-throughput

0.279

Low

858805

RM01
Large ribosomal subunit protein uL1m

1

0

High-throughput

0.279

Low

760413

SDC2
Syndecan-2

1

0

Small-scale

0.249

Low

858765

TNAP2
Tumor necrosis factor alpha-induced protein 2

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025