HitPredict

Interactor 1: MED15 (Q6NS15)
Mediator of RNA polymerase II transcription subunit 15 (Activator-recruited cofactor 105 kDa component) (ARC105) (xARC105) (Mediator complex subunit 15)
Gene: MED15

Interactor 2: Q90YE5 (Q90YE5)
Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member)
Gene: smad3.L

Species: Xenopus laevis

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	12167862
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 777 Xl			1 425
+	Xl
		1153625 MED15_XENLA (408-777): 1.61e-73: 256: 100.00		Q6IRR4_XENLA (1-425): 0: 600: 82.23
+	Hs
		950253 MED15_HUMAN (4-139): 7.33e-34: 141: 69.12		SMAD3_HUMAN (1-425): 0: 634: 95.31
+	Hs
		1078631 MED15_HUMAN (4-139): 7.33e-34: 141: 69.12		SMAD2_HUMAN (1-425): 0: 602: 82.01
+	Hs
		1078747 MED15_HUMAN (4-139): 7.33e-34: 141: 69.12		SMAD1_HUMAN (1-425): 0: 580: 59.87
+	Dm
		785517 MED15_DROME (6-121): 1.39e-23: 108: 30.66		MAD_DROME (1-425): 0: 595: 60.41
+	Xl
		1155784 MED15_XENLA (408-777): 1.61e-73: 256: 100.00		Q9W639_XENLA (23-414): 4.93e-130: 387: 32.95
+	Hs
		171398 PLEC_HUMAN (128-641): 7.21e-09: 62: 11.05		SMAD9_HUMAN (1-425): 0: 581: 59.05
+	Hs
		1035561 MED15_HUMAN (4-139): 7.33e-34: 141: 69.12		SMAD4_HUMAN (23-414): 2.58e-130: 388: 32.37
+	Hs
		254477 ROCK2_HUMAN (155-592): 2e-19: 95.9: 10.97		SMAD4_HUMAN (23-414): 2.58e-130: 388: 32.37
+	Hs
		255317 HIP1R_HUMAN (106-564): 4.25e-18: 91.3: 11.68		SMAD4_HUMAN (23-414): 2.58e-130: 388: 32.37
+	Hs
		1035470 MRCKG_HUMAN (165-660): 6.35e-16: 84.7: 11.69		SMAD4_HUMAN (23-414): 2.58e-130: 388: 32.37