Protein: UBP22
Ubiquitin carboxyl-terminal hydrolase 22 (EC 3.4.19.12) (Deubiquitinating enzyme 22) (Ubiquitin thioesterase 22) (Ubiquitin-specific-processing protease 22)

Gene: UBP22, USP22
Organism: Homo sapiens
Interactions: 159
UniProt ID: Q9UPT9

Gene Ontology (top 5):
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0000124 - SAGA complex
GO:0003713 - transcription coactivator activity
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1135648

AT7L3
Ataxin-7-like protein 3

14

4

Small-scale

0.982

High

1453554

PD1L1
Programmed cell death 1 ligand 1

5

5

Small-scale

0.931

High

1446151

ENY2
Transcription and mRNA export factor ENY2

5

3

Small-scale

0.922

High

284994

TAF5L
TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L

3

10

High-throughput

0.861

High

67148

UBP27
Ubiquitin carboxyl-terminal hydrolase 27

2

13

High-throughput

0.789

High

1462580

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

2

12

Small-scale

0.754

High

1369180

KAT2A
Histone acetyltransferase KAT2A

11

13

Small-scale

0.754

High

1388778

SIR1
NAD-dependent protein deacetylase sirtuin-1

11

1

Small-scale

0.753

High

184754

ATX7
Ataxin-7

7

10

Small-scale

0.748

High

1337593

SP20H
Transcription factor SPT20 homolog

7

2

Small-scale

0.746

High

1389709

SGF29
SAGA-associated factor 29

6

3

Small-scale

0.733

High

1462582

TRRAP
Transformation/transcription domain-associated protein

6

8

Small-scale

0.730

High

373511

MYC
Myc proto-oncogene protein

6

6

Small-scale

0.729

High

283632

SUPT3
Transcription initiation protein SPT3 homolog

5

3

Small-scale

0.714

High

284900

TADA3
Transcriptional adapter 3

5

3

Small-scale

0.714

High

1384794

TADA1
Transcriptional adapter 1

4

3

High-throughput

0.699

High

639415

5NTD
5'-nucleotidase

4

3

Small-scale

0.694

High

1287336

TAD2B
Transcriptional adapter 2-beta

4

6

High-throughput

0.694

High

828261

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

13

High-throughput

0.691

High

1367894

ARC1A
Actin-related protein 2/3 complex subunit 1A

1

9

High-throughput

0.691

High

1091655

TAF10
Transcription initiation factor TFIID subunit 10

4

1

Small-scale

0.676

High

319185

ST65G
STAGA complex 65 subunit gamma

3

2

High-throughput

0.667

High

881340

FAS
Fatty acid synthase

3

1

Small-scale

0.667

High

1159346

TAF9
Transcription initiation factor TFIID subunit 9

3

5

High-throughput

0.667

High

1462584

TAF6L
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L

3

3

High-throughput

0.667

High

967028

1433G
14-3-3 protein gamma

3

20

High-throughput

0.662

High

1438404

TAF9B
Transcription initiation factor TFIID subunit 9B

3

5

Small-scale

0.656

High

508843

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

20

High-throughput

0.647

High

1334094

MINY2
Ubiquitin carboxyl-terminal hydrolase MINDY-2

3

0

High-throughput

0.638

High

247036

KDM1A
Lysine-specific histone demethylase 1A

3

0

Small-scale

0.636

High

354265

ZBED1
E3 SUMO-protein ligase ZBED1

2

1

High-throughput

0.628

High

1252089

RN19B
E3 ubiquitin-protein ligase RNF19B

2

8

High-throughput

0.628

High

1384382

CR3L1
Cyclic AMP-responsive element-binding protein 3-like protein 1

2

3

High-throughput

0.628

High

857597

NOTC1
Neurogenic locus notch homolog protein 1

1

7

Small-scale

0.618

High

1258110

UBP51
Ubiquitin carboxyl-terminal hydrolase 51

1

16

High-throughput

0.618

High

1157616

TAF12
Transcription initiation factor TFIID subunit 12

2

2

High-throughput

0.611

High

1178654

KIF7
Kinesin-like protein KIF7

2

3

High-throughput

0.611

High

1392519

A7L3B
Ataxin-7-like protein 3B

2

3

Small-scale

0.611

High

706000

CD1B
T-cell surface glycoprotein CD1b

3

1

High-throughput

0.609

High

1206031

MTUS2
Microtubule-associated tumor suppressor candidate 2

2

6

High-throughput

0.606

High

260619

BRD4
Bromodomain-containing protein 4

2

11

Small-scale

0.584

High

1369225

KAT2B
Histone acetyltransferase KAT2B

2

11

High-throughput

0.584

High

336804

BAG4
BAG family molecular chaperone regulator 4

2

0

High-throughput

0.580

High

770790

PGH2
Prostaglandin G/H synthase 2

1

1

Small-scale

0.578

High

388333

GLPA
Glycophorin-A

2

0

High-throughput

0.576

High

276230

LRRN2
Leucine-rich repeat neuronal protein 2

2

3

High-throughput

0.574

High

1159123

C3AR
C3a anaphylatoxin chemotactic receptor

2

2

High-throughput

0.574

High

1248850

ENPP6
Glycerophosphocholine cholinephosphodiesterase ENPP6

2

1

High-throughput

0.574

High

1461606

AT7L1
Ataxin-7-like protein 1

2

11

High-throughput

0.574

High

573912

CCNB1
G2/mitotic-specific cyclin-B1

1

2

Small-scale

0.561

High

766016

BMI1
Polycomb complex protein BMI-1

1

11

Small-scale

0.561

High

789597

PPARG
Peroxisome proliferator-activated receptor gamma

1

6

Small-scale

0.561

High

790111

ZEB1
Zinc finger E-box-binding homeobox 1

1

2

Small-scale

0.561

High

1294968

PALB2
Partner and localizer of BRCA2

1

1

Small-scale

0.561

High

1213445

AT7L2
Ataxin-7-like protein 2

2

9

High-throughput

0.558

High

1382863

FUBP1
Far upstream element-binding protein 1

1

2

Small-scale

0.554

High

192759

ARPC5
Actin-related protein 2/3 complex subunit 5

1

1

High-throughput

0.536

High

486642

TACD2
Tumor-associated calcium signal transducer 2

1

1

High-throughput

0.536

High

605851

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

3

High-throughput

0.536

High

691542

1433T
14-3-3 protein theta

1

20

High-throughput

0.536

High

958225

ARP3
Actin-related protein 3

1

1

High-throughput

0.536

High

958380

ARP2
Actin-related protein 2

1

1

High-throughput

0.536

High

1036702

APBA1
Amyloid-beta A4 precursor protein-binding family A member 1

1

1

High-throughput

0.536

High

1049912

1433F
14-3-3 protein eta

1

20

High-throughput

0.536

High

1148085

SF3B3
Splicing factor 3B subunit 3

1

2

High-throughput

0.536

High

1194865

PPCEL
Prolyl endopeptidase-like

1

1

High-throughput

0.536

High

1333285

KLH23
Kelch-like protein 23

1

2

High-throughput

0.536

High

1409701

ARP5L
Actin-related protein 2/3 complex subunit 5-like protein

1

1

High-throughput

0.536

High

923679

RCAN1
Calcipressin-1

1

0

Small-scale

0.529

High

1054672

PSME1
Proteasome activator complex subunit 1

1

0

High-throughput

0.518

High

1281364

RM10
Large ribosomal subunit protein uL10m

1

0

High-throughput

0.518

High

1106393

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

2

Small-scale

0.515

High

64155

CNOT1
CCR4-NOT transcription complex subunit 1

1

0

High-throughput

0.513

High

179415

ARPC2
Actin-related protein 2/3 complex subunit 2

1

0

High-throughput

0.513

High

289097

DEDD
Death effector domain-containing protein

1

0

High-throughput

0.513

High

1125785

FA50A
Protein FAM50A

1

0

High-throughput

0.513

High

1270447

SND1
Staphylococcal nuclease domain-containing protein 1

1

0

High-throughput

0.513

High

1313722

IFT20
Intraflagellar transport protein 20 homolog

1

0

High-throughput

0.513

High

1428923

CTDS1
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

1

0

High-throughput

0.513

High

1436902

CNO10
CCR4-NOT transcription complex subunit 10

1

0

High-throughput

0.513

High

1437127

RM44
Large ribosomal subunit protein mL44

1

1

High-throughput

0.508

High

419275

H2A1B
Histone H2A type 1-B/E

1

14

Small-scale

0.501

High

755032

H2B1B
Histone H2B type 1-B

1

16

Small-scale

0.501

High

1162926

H2A2C
Histone H2A type 2-C

1

14

Small-scale

0.501

High

1163294

H2B2E
Histone H2B type 2-E

1

16

Small-scale

0.501

High

192141

PA2GX
Group 10 secretory phospholipase A2

1

2

High-throughput

0.489

High

1213734

LRAD1
Low-density lipoprotein receptor class A domain-containing protein 1

1

3

High-throughput

0.489

High

1402160

RB40C
Ras-related protein Rab-40C

1

1

High-throughput

0.489

High

1433007

DNJC5
DnaJ homolog subfamily C member 5

1

2

High-throughput

0.489

High

179749

MDM4
Protein Mdm4

1

6

Small-scale

0.479

High

188728

BIRC5
Baculoviral IAP repeat-containing protein 5

1

3

Small-scale

0.479

High

228002

MYO1B
Unconventional myosin-Ib

1

3

Small-scale

0.479

High

282802

E2F6
Transcription factor E2F6

1

3

Small-scale

0.479

High

283571

TAD2A
Transcriptional adapter 2-alpha

1

6

Small-scale

0.479

High

443561

CDK1
Cyclin-dependent kinase 1

1

5

Small-scale

0.479

High

520459

ANDR
Androgen receptor

1

9

Small-scale

0.479

High

550525

PABP1
Polyadenylate-binding protein 1

1

1

Small-scale

0.479

High

557531

SRC
Proto-oncogene tyrosine-protein kinase Src

1

3

Small-scale

0.479

High

587838

DESP
Desmoplakin

1

2

Small-scale

0.479

High

590044

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

693138

DPP4
Dipeptidyl peptidase 4

1

1

Small-scale

0.479

High

696876

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.479

High

827966

STAT3
Signal transducer and activator of transcription 3

1

5

Small-scale

0.479

High

838201

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

5

Small-scale

0.479

High

862557

YAP1
Transcriptional coactivator YAP1

1

5

Small-scale

0.479

High

905295

MECP2
Methyl-CpG-binding protein 2

1

3

High-throughput

0.479

High

910736

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

4

Small-scale

0.479

High

1008404

PRKDC
DNA-dependent protein kinase catalytic subunit

1

8

Small-scale

0.479

High

1032886

XPC
DNA repair protein complementing XP-C cells

1

1

Small-scale

0.479

High

1086940

CDC20
Cell division cycle protein 20 homolog

1

6

Small-scale

0.479

High

1114673

CUL3
Cullin-3

1

2

High-throughput

0.479

High

1155909

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

Small-scale

0.479

High

1161443

HIF1A
Hypoxia-inducible factor 1-alpha

1

6

Small-scale

0.479

High

1220894

RN123
E3 ubiquitin-protein ligase RNF123

1

4

High-throughput

0.479

High

1256117

TRI67
Tripartite motif-containing protein 67

1

17

High-throughput

0.479

High

1278148

MAVS
Mitochondrial antiviral-signaling protein

1

3

Small-scale

0.479

High

1292891

STING
Stimulator of interferon genes protein

1

2

Small-scale

0.479

High

1383627

E2F7
Transcription factor E2F7

1

3

Small-scale

0.479

High

1405749

KLF6
Krueppel-like factor 6

1

3

High-throughput

0.479

High

1461212

IKZF2
Zinc finger protein Helios

1

1

Small-scale

0.479

High

184337

NPHP1
Nephrocystin-1

1

0

High-throughput

0.458

High

290205

OFD1
Centriole and centriolar satellite protein OFD1

1

0

High-throughput

0.458

High

460667

SYEP
Bifunctional glutamate/proline--tRNA ligase

1

0

Small-scale

0.458

High

609943

SPI1
Transcription factor PU.1

1

0

Small-scale

0.458

High

834558

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

0

Small-scale

0.458

High

1323188

CCAR2
Cell cycle and apoptosis regulator protein 2

1

0

Small-scale

0.458

High

1460731

CDC23
Cell division cycle protein 23 homolog

1

0

Small-scale

0.458

High

437831

HEPS
Serine protease hepsin

1

1

High-throughput

0.445

High

1384307

SH3K1
SH3 domain-containing kinase-binding protein 1

1

10

High-throughput

0.445

High

610943

TCPA
T-complex protein 1 subunit alpha

1

5

Small-scale

0.437

High

829598

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

2

Small-scale

0.437

High

902912

BLK
Tyrosine-protein kinase Blk

1

3

High-throughput

0.437

High

887341

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.408

High

1462583

NPTN
Neuroplastin

1

1

High-throughput

0.407

High

1448737

ADPPT
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase

7

0

High-throughput

0.392

High

332720

LYPD3
Ly6/PLAUR domain-containing protein 3

3

0

High-throughput

0.347

High

1279103

RIC3
Protein RIC-3

3

0

High-throughput

0.347

High

181029

LRAD4
Low-density lipoprotein receptor class A domain-containing protein 4

2

0

High-throughput

0.328

High

749303

CD70
CD70 antigen

2

0

High-throughput

0.328

High

1146657

TMED2
Transmembrane emp24 domain-containing protein 2

2

0

High-throughput

0.328

High

1308422

UN5CL
UNC5C-like protein

2

0

High-throughput

0.328

High

1436019

PACC1
Proton-activated chloride channel

2

0

High-throughput

0.328

High

1363165

CLC2B
C-type lectin domain family 2 member B

2

0

High-throughput

0.313

High

449583

HEXA
Beta-hexosaminidase subunit alpha

1

0

High-throughput

0.282

High

1358401

SCFD1
Sec1 family domain-containing protein 1

1

0

High-throughput

0.282

High

167179

T4S5
Transmembrane 4 L6 family member 5

1

0

High-throughput

0.279

Low

209141

CYB5B
Cytochrome b5 type B

1

0

High-throughput

0.279

Low

485957

GIP
Gastric inhibitory polypeptide

1

0

High-throughput

0.279

Low

867520

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.279

Low

1103116

MFAP5
Microfibrillar-associated protein 5

1

0

High-throughput

0.279

Low

1132594

FXYD3
FXYD domain-containing ion transport regulator 3

1

0

High-throughput

0.279

Low

1240287

FXL22
F-box and leucine-rich protein 22

1

0

High-throughput

0.279

Low

1248544

LCTL
Lactase-like protein

1

0

High-throughput

0.279

Low

1358041

TM171
Transmembrane protein 171

1

0

High-throughput

0.279

Low

1430705

F234A
Protein FAM234A

1

0

High-throughput

0.279

Low

1460834

CC018
Uncharacterized protein C3orf18

1

0

High-throughput

0.279

Low

1462581

OFUT2
GDP-fucose protein O-fucosyltransferase 2

1

0

High-throughput

0.279

Low

568099

HLAE
HLA class I histocompatibility antigen, alpha chain E

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025