HitPredict

Interactor 1: PHLB3 (Q6NSJ2)
Pleckstrin homology-like domain family B member 3
Gene: PHLDB3

Interactor 2: CNKR1 (Q969H4)
Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR 1) (CNK homolog protein 1) (CNK1) (hCNK1) (Connector enhancer of KSR-like)
Gene: CNKSR1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.80	0.726

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PH~PH
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 640 Hs			1 720
+	Hs
		212319 CYH3_HUMAN (532-630): 1.47e-22: 102: 26.96		CNKR1_HUMAN (1-720): 0: 556: 100.00
+	Hs
		1155855 PHLB3_HUMAN (1-640): 4.05e-106: 336: 100.00		SKAP1_HUMAN (398-546): 1.13e-21: 99.2: 22.22
+	Hs
		724781 MYH9_HUMAN (8-493): 2.61e-35: 145: 9.45		SPTB2_HUMAN (12-538): 1.01e-75: 268: 13.64
+	Hs
		963324 DCTN1_HUMAN (2-464): 1.01e-34: 143: 14.99		SPTB2_HUMAN (12-538): 1.01e-75: 268: 13.64
+	Mm
		1169650 TAOK2_MOUSE (69-543): 3.52e-40: 160: 17.14		CNKR2_MOUSE (77-719): 4.09e-59: 218: 18.20
+	Hs
		164575 MYH9_HUMAN (8-493): 2.61e-35: 145: 9.45		SPTN2_HUMAN (12-552): 1.63e-50: 193: 13.76
+	Hs
		1051468 DCTN1_HUMAN (2-464): 1.01e-34: 143: 14.99		PKHA5_HUMAN (330-717): 1.02e-47: 184: 15.74
+	Mm
		140106 CYH3_MOUSE (532-630): 3.88e-24: 107: 27.19		CNKR2_MOUSE (77-719): 4.09e-59: 218: 18.20
+	Hs
		724876 MYH9_HUMAN (8-493): 2.61e-35: 145: 9.45		PKHA7_HUMAN (323-700): 1.06e-40: 162: 15.29
+	Hs
		724864 MYH9_HUMAN (8-493): 2.61e-35: 145: 9.45		RHG21_HUMAN (93-687): 1.28e-37: 153: 14.13
+	Hs
		724916 MYH9_HUMAN (8-493): 2.61e-35: 145: 9.45		AFAP1_HUMAN (299-625): 3.71e-38: 153: 15.12
+	Hs
		1051315 DCTN1_HUMAN (2-464): 1.01e-34: 143: 14.99		RHG21_HUMAN (93-687): 1.28e-37: 153: 14.13
+	Hs
		212313 CYH3_HUMAN (532-630): 1.47e-22: 102: 26.96		CYH1_HUMAN (165-524): 2.61e-50: 182: 13.51
+	Hs
		728515 MYH11_HUMAN (8-493): 3.69e-37: 151: 11.29		PKHA4_HUMAN (383-502): 7.85e-26: 115: 26.40
+	Hs
		725019 MYH9_HUMAN (8-493): 2.61e-35: 145: 9.45		PKHA4_HUMAN (383-502): 7.85e-26: 115: 26.40
+	Hs
		1051461 DCTN1_HUMAN (2-464): 1.01e-34: 143: 14.99		PKHA4_HUMAN (383-502): 7.85e-26: 115: 26.40
+	Hs
		309499 MTMR5_HUMAN (399-632): 4.92e-37: 150: 19.78		SKAP1_HUMAN (398-546): 1.13e-21: 99.2: 22.22
+	Hs
		551742 DESP_HUMAN (66-484): 4.25e-09: 62: 13.26		PKHA7_HUMAN (323-700): 1.06e-40: 162: 15.29
+	Hs
		724914 MYH9_HUMAN (8-493): 2.61e-35: 145: 9.45		RHG24_HUMAN (402-522): 1.74e-13: 76.1: 21.21
+	Hs
		212317 CYH3_HUMAN (532-630): 1.47e-22: 102: 26.96		ICEF1_HUMAN (504-704): 8.62e-15: 79.4: 26.37