Protein: CATB
Cathepsin B (EC 3.4.22.1) (APP secretase) (APPS) (Cathepsin B1) [Cleaved into: Cathepsin B light chain; Cathepsin B heavy chain]

Gene: CATB, CTSB
Organism: Homo sapiens
Interactions: 199
UniProt ID: P07858

Gene Ontology (top 5):
GO:0004197 - cysteine-type endopeptidase activity
GO:0005518 - collagen binding
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005764 - lysosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

370262

CYTA
Cystatin-A

4

7

Small-scale

0.896

High

402741

CYTB
Cystatin-B

3

7

Small-scale

0.840

High

370029

CYTC
Cystatin-C

2

17

Small-scale

0.799

High

460752

CATB
Cathepsin B

1

10

High-throughput

0.665

High

460770

CATS
Cathepsin S

1

8

High-throughput

0.618

High

389620

AMBP
Protein AMBP

2

3

Small-scale

0.608

High

456567

ANXA2
Annexin A2

2

2

Small-scale

0.595

High

460783

BAG6
Large proline-rich protein BAG6

1

2

High-throughput

0.541

High

460780

MLH1
DNA mismatch repair protein Mlh1

1

2

Small-scale

0.535

High

403742

GCR
Glucocorticoid receptor

2

3

Small-scale

0.533

High

460764

BRAF
Serine/threonine-protein kinase B-raf

2

5

High-throughput

0.521

High

460824

STK11
Serine/threonine-protein kinase STK11

1

0

High-throughput

0.518

High

123559

MYO1C
Unconventional myosin-Ic

1

8

High-throughput

0.515

High

174691

SPTN2
Spectrin beta chain, non-erythrocytic 2

1

10

High-throughput

0.515

High

179443

ARPC3
Actin-related protein 2/3 complex subunit 3

1

2

High-throughput

0.515

High

224587

ACTN4
Alpha-actinin-4

1

7

High-throughput

0.515

High

227766

MYO1B
Unconventional myosin-Ib

1

8

High-throughput

0.515

High

270301

WDR1
WD repeat-containing protein 1

1

3

High-throughput

0.515

High

318242

MYO1D
Unconventional myosin-Id

1

8

High-throughput

0.515

High

409221

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

4

High-throughput

0.515

High

413029

P53
Cellular tumor antigen p53

1

2

High-throughput

0.515

High

417215

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

5

High-throughput

0.515

High

458658

SAP
Prosaposin

1

2

High-throughput

0.515

High

460756

MPRI
Cation-independent mannose-6-phosphate receptor

1

7

High-throughput

0.515

High

460757

ACTN1
Alpha-actinin-1

1

7

High-throughput

0.515

High

460760

PDIA4
Protein disulfide-isomerase A4

1

11

High-throughput

0.515

High

460762

ENPL
Endoplasmin

1

3

High-throughput

0.515

High

460768

PFKAL
ATP-dependent 6-phosphofructokinase, liver type

1

5

High-throughput

0.515

High

460771

CALR
Calreticulin

1

6

High-throughput

0.515

High

460772

GRN
Progranulin

1

1

High-throughput

0.515

High

460774

PDIA3
Protein disulfide-isomerase A3

1

12

High-throughput

0.515

High

460786

LMAN1
Protein ERGIC-53

1

2

High-throughput

0.515

High

460788

SERPH
Serpin H1

1

5

High-throughput

0.515

High

460798

TPM4
Tropomyosin alpha-4 chain

1

3

High-throughput

0.515

High

460802

NUCB2
Nucleobindin-2

1

1

High-throughput

0.515

High

460803

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

5

High-throughput

0.515

High

460808

CKAP4
Cytoskeleton-associated protein 4

1

3

High-throughput

0.515

High

460811

TWF1
Twinfilin-1

1

1

High-throughput

0.515

High

460813

PRDX4
Peroxiredoxin-4

1

2

High-throughput

0.515

High

460817

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

10

High-throughput

0.515

High

460821

GANAB
Neutral alpha-glucosidase AB

1

2

High-throughput

0.515

High

460870

AIF1L
Allograft inflammatory factor 1-like

1

3

High-throughput

0.515

High

460890

DJB11
DnaJ homolog subfamily B member 11

1

5

High-throughput

0.515

High

460895

BAG5
BAG family molecular chaperone regulator 5

1

2

High-throughput

0.515

High

460896

MYO6
Unconventional myosin-VI

1

2

High-throughput

0.515

High

460901

HYOU1
Hypoxia up-regulated protein 1

1

5

High-throughput

0.515

High

460873

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.513

High

460769

ANXA7
Annexin A7

1

2

High-throughput

0.508

High

460838

ATL4
ADAMTS-like protein 4

1

1

Small-scale

0.506

High

460795

S10AA
Protein S100-A10

1

0

Small-scale

0.504

High

460859

SH3K1
SH3 domain-containing kinase-binding protein 1

1

3

Small-scale

0.504

High

421324

A4
Amyloid-beta precursor protein

1

3

High-throughput

0.501

High

460753

PARP1
Poly [ADP-ribose] polymerase 1

1

1

Small-scale

0.501

High

460876

UBP29
Ubiquitin carboxyl-terminal hydrolase 29

1

0

High-throughput

0.493

High

165693

PPE1
Serine/threonine-protein phosphatase with EF-hands 1

1

3

High-throughput

0.489

High

460785

PTSS1
Phosphatidylserine synthase 1

1

2

High-throughput

0.489

High

460810

DMWD
Dystrophia myotonica WD repeat-containing protein

1

3

High-throughput

0.489

High

460848

HIPK4
Homeodomain-interacting protein kinase 4

1

2

High-throughput

0.489

High

460878

ST7
Suppressor of tumorigenicity 7 protein

1

2

High-throughput

0.489

High

460881

UBQL4
Ubiquilin-4

1

4

Small-scale

0.481

High

174903

SC16A
Protein transport protein Sec16A

1

2

High-throughput

0.479

High

229623

CALU
Calumenin

1

5

High-throughput

0.479

High

251845

PLOD3
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3

1

5

High-throughput

0.479

High

369962

CO5
Complement C5

1

1

Small-scale

0.479

High

377361

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

1

High-throughput

0.479

High

390269

VTDB
Vitamin D-binding protein

1

1

Small-scale

0.479

High

399526

VTNC
Vitronectin

1

1

Small-scale

0.479

High

400140

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

6

High-throughput

0.479

High

460754

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

4

High-throughput

0.479

High

460755

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

460758

CADH1
Cadherin-1

1

3

High-throughput

0.479

High

460763

MMP9
Matrix metalloproteinase-9

1

2

Small-scale

0.479

High

460765

TIMP2
Metalloproteinase inhibitor 2

1

1

High-throughput

0.479

High

460773

ERP29
Endoplasmic reticulum resident protein 29

1

12

High-throughput

0.479

High

460775

AMRP
Alpha-2-macroglobulin receptor-associated protein

1

1

High-throughput

0.479

High

460777

PHB1
Prohibitin 1

1

4

High-throughput

0.479

High

460787

TMEDA
Transmembrane emp24 domain-containing protein 10

1

1

High-throughput

0.479

High

460790

SYYC
Tyrosine--tRNA ligase, cytoplasmic

1

3

High-throughput

0.479

High

460791

MANF
Mesencephalic astrocyte-derived neurotrophic factor

1

1

High-throughput

0.479

High

460801

CCL20
C-C motif chemokine 20

1

2

Small-scale

0.479

High

460806

COEA1
Collagen alpha-1(XIV) chain

1

3

High-throughput

0.479

High

460809

DSC1
Desmocollin-1

1

3

Small-scale

0.479

High

460812

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

3

High-throughput

0.479

High

460815

CUL3
Cullin-3

1

3

High-throughput

0.479

High

460819

DSC3
Desmocollin-3

1

3

High-throughput

0.479

High

460822

SYK
Lysine--tRNA ligase

1

3

High-throughput

0.479

High

460831

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

1

3

High-throughput

0.479

High

460841

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

2

High-throughput

0.479

High

460846

NHLC2
NHL repeat-containing protein 2

1

1

High-throughput

0.479

High

460855

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

460860

ERO1A
ERO1-like protein alpha

1

1

High-throughput

0.479

High

460877

SDF2L
Stromal cell-derived factor 2-like protein 1

1

2

High-throughput

0.479

High

460879

FBX6
F-box only protein 6

1

3

High-throughput

0.479

High

460887

UGGG1
UDP-glucose:glycoprotein glucosyltransferase 1

1

3

High-throughput

0.479

High

460893

HERC5
E3 ISG15--protein ligase HERC5

1

1

Small-scale

0.479

High

460897

MINP1
Multiple inositol polyphosphate phosphatase 1

1

1

High-throughput

0.479

High

460898

CE164
Centrosomal protein of 164 kDa

1

2

High-throughput

0.479

High

321156

ERLN2
Erlin-2

1

6

High-throughput

0.470

High

346812

BAG2
BAG family molecular chaperone regulator 2

1

2

High-throughput

0.470

High

417894

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

2

High-throughput

0.470

High

460761

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

3

High-throughput

0.470

High

460779

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

2

High-throughput

0.470

High

460793

RBM11
Splicing regulator RBM11

1

2

High-throughput

0.470

High

460800

PRKDC
DNA-dependent protein kinase catalytic subunit

1

2

High-throughput

0.470

High

460814

OS9
Protein OS-9

1

1

High-throughput

0.470

High

460823

RCN1
Reticulocalbin-1

1

5

High-throughput

0.470

High

460828

GLO2
Hydroxyacylglutathione hydrolase, mitochondrial

1

1

High-throughput

0.470

High

460834

UBR4
E3 ubiquitin-protein ligase UBR4

1

2

High-throughput

0.470

High

460847

GT251
Procollagen galactosyltransferase 1

1

5

High-throughput

0.470

High

460852

IPO4
Importin-4

1

2

High-throughput

0.470

High

460856

MY18A
Unconventional myosin-XVIIIa

1

2

High-throughput

0.470

High

460865

RBM15
RNA-binding protein 15

1

1

High-throughput

0.470

High

460867

RNF5
E3 ubiquitin-protein ligase RNF5

1

3

High-throughput

0.470

High

460891

SE1L1
Protein sel-1 homolog 1

1

2

High-throughput

0.470

High

460894

RALY
RNA-binding protein Raly

1

1

High-throughput

0.470

High

221079

SPY2
Protein sprouty homolog 2

1

1

High-throughput

0.464

High

164222

NRP1
Neuropilin-1

1

0

High-throughput

0.458

High

362612

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

370952

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

387611

APOC2
Apolipoprotein C-II

1

0

Small-scale

0.458

High

388573

SAMP
Serum amyloid P-component

1

0

Small-scale

0.458

High

389779

TTHY
Transthyretin

1

0

Small-scale

0.458

High

399925

CATA
Catalase

1

0

Small-scale

0.458

High

460781

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

460789

LUM
Lumican

1

0

Small-scale

0.458

High

460837

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

460866

SORT
Sortilin

1

0

High-throughput

0.458

High

411200

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.457

High

460792

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

3

High-throughput

0.445

High

460845

XRN1
5'-3' exoribonuclease 1

1

2

High-throughput

0.439

High

460880

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

128495

RN103
E3 ubiquitin-protein ligase RNF103

1

2

High-throughput

0.437

High

302330

RNF8
E3 ubiquitin-protein ligase RNF8

1

1

High-throughput

0.437

High

350571

TXD12
Thioredoxin domain-containing protein 12

1

2

High-throughput

0.437

High

460767

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.437

High

460784

CD151
CD151 antigen

1

2

Small-scale

0.437

High

460799

NOMO3
BOS complex subunit NOMO3

1

3

High-throughput

0.437

High

460804

M2OM
Mitochondrial 2-oxoglutarate/malate carrier protein

1

8

High-throughput

0.437

High

460807

CDK18
Cyclin-dependent kinase 18

1

1

High-throughput

0.437

High

460816

CUL4A
Cullin-4A

1

3

High-throughput

0.437

High

460820

MESD
LRP chaperone MESD

1

1

High-throughput

0.437

High

460827

HIF1A
Hypoxia-inducible factor 1-alpha

1

1

High-throughput

0.437

High

460830

GXLT1
Glucoside xylosyltransferase 1

1

1

High-throughput

0.437

High

460832

TGO1
Transport and Golgi organization protein 1 homolog

1

2

High-throughput

0.437

High

460833

TOIP1
Torsin-1A-interacting protein 1

1

1

High-throughput

0.437

High

460836

FTM
Protein fantom

1

3

High-throughput

0.437

High

460839

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

460842

YTHD3
YTH domain-containing family protein 3

1

4

High-throughput

0.437

High

460843

DJC10
DnaJ homolog subfamily C member 10

1

14

High-throughput

0.437

High

460844

S15A3
Solute carrier family 15 member 3

1

1

High-throughput

0.437

High

460849

STT3B
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

1

2

High-throughput

0.437

High

460850

PO210
Nuclear pore membrane glycoprotein 210

1

1

High-throughput

0.437

High

460851

FBF1
Fas-binding factor 1

1

4

High-throughput

0.437

High

460853

RN139
E3 ubiquitin-protein ligase RNF139

1

1

High-throughput

0.437

High

460854

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

1

2

High-throughput

0.437

High

460857

ESR2
Estrogen receptor beta

1

3

High-throughput

0.437

High

460858

EFMT3
EEF1A lysine methyltransferase 3

1

1

High-throughput

0.437

High

460863

SCLT1
Sodium channel and clathrin linker 1

1

3

High-throughput

0.437

High

460864

NEB2
Neurabin-2

1

1

High-throughput

0.437

High

460871

CNPY3
Protein canopy homolog 3

1

1

High-throughput

0.437

High

460872

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

1

High-throughput

0.437

High

460874

WDR26
WD repeat-containing protein 26

1

3

High-throughput

0.437

High

460875

XPO5
Exportin-5

1

3

High-throughput

0.437

High

460883

GID8
Glucose-induced degradation protein 8 homolog

1

1

High-throughput

0.437

High

460886

UGGG2
UDP-glucose:glycoprotein glucosyltransferase 2

1

5

High-throughput

0.437

High

460892

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.437

High

460900

CNPY2
Protein canopy homolog 2

1

1

High-throughput

0.437

High

339035

GTR10
Solute carrier family 2, facilitated glucose transporter member 10

1

0

High-throughput

0.426

High

460759

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.426

High

460899

S22AD
Solute carrier family 22 member 13

1

0

High-throughput

0.426

High

104094

F5H1C8
Solute carrier family 15 member 3

1

1

High-throughput

0.407

High

460776

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.407

High

460835

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.407

High

460902

SO1B1
Solute carrier organic anion transporter family member 1B1

1

1

High-throughput

0.407

High

460782

RGS2
Regulator of G-protein signaling 2

2

0

High-throughput

0.307

High

460862

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.282

High

66864

SPDE4
Speedy protein E4

1

0

High-throughput

0.279

Low

160394

IRS4
Insulin receptor substrate 4

1

0

High-throughput

0.279

Low

460861

BOD1
Biorientation of chromosomes in cell division protein 1

1

0

High-throughput

0.268

Low

460778

CDN1A
Cyclin-dependent kinase inhibitor 1

1

0

High-throughput

0.265

Low

460826

HSPB2
Heat shock protein beta-2

1

0

High-throughput

0.265

Low

460869

F118B
Protein FAM118B

1

0

High-throughput

0.265

Low

460805

ERCC6
DNA excision repair protein ERCC-6

1

0

High-throughput

0.261

Low

460818

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

0

High-throughput

0.251

Low

261998

NBN
Nibrin

1

0

High-throughput

0.249

Low

460766

H13
Histone H1.3

1

0

Small-scale

0.249

Low

460796

ABCE1
ATP-binding cassette sub-family E member 1

1

0

High-throughput

0.249

Low

460797

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.249

Low

460825

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.249

Low

460829

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low

460840

TPGS1
Tubulin polyglutamylase complex subunit 1

1

0

High-throughput

0.249

Low

460868

PTN18
Tyrosine-protein phosphatase non-receptor type 18

1

0

High-throughput

0.249

Low

460882

RMND1
Required for meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.249

Low

460884

TEX10
Testis-expressed protein 10

1

0

High-throughput

0.249

Low

460888

TMOD2
Tropomodulin-2

1

0

High-throughput

0.249

Low

460889

MARH4
E3 ubiquitin-protein ligase MARCHF4

1

0

High-throughput

0.249

Low

460794

DSCR9
Down syndrome critical region protein 9

1

0

High-throughput

0.238

Low

460885

SPHK1
Sphingosine kinase 1

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025