HitPredict

Interactor 1: PAXI1 (Q6NZQ4)
PAX-interacting protein 1 (PAX transactivation activation domain-interacting protein)
Gene: Paxip1

Interactor 2: KMT2D (Q6PDK2)
Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2)
Gene: KMT2D

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	26744420
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0035097 - histone methyltransferase complex GO:0044666 - MLL3/4 complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1056 Mm			1 5588
+	Hs
		1173276 PAXI1_HUMAN (579-1056): 1.85e-139: 448: 92.47		KMT2B_HUMAN (92-219): 2.29e-24: 116: 27.27
+	Hs
		165687 PAXI1_HUMAN (579-1056): 1.85e-139: 448: 92.47		SET1A_HUMAN (5447-5588): 5.72e-22: 108: 46.15
+	Hs
		1173279 PAXI1_HUMAN (579-1056): 1.85e-139: 448: 92.47		SET1B_HUMAN (5455-5588): 9.23e-22: 107: 48.89
+	Hs
		1173188 PAXI1_HUMAN (579-1056): 1.85e-139: 448: 92.47		KMT2C_HUMAN (761-3205): 6.91e-12: 75.2: 7.52
+	Mm
		1157867 PAXI1_MOUSE (545-1056): 1.1e-138: 446: 100.00		KMT2C_MOUSE (1325-1719): 3.28e-12: 76.3: 19.65
+	Hs
		975277 PAXI1_HUMAN (579-1056): 1.85e-139: 448: 92.47		KMT2A_HUMAN (2178-2926): 4.56e-10: 69: 12.34
+	Hs
		152660 PAXI1_HUMAN (579-1056): 1.85e-139: 448: 92.47		KMT2D_HUMAN (115-226): 8.07e-10: 68.3: 31.25
+	Hs
		203749 TOPB1_HUMAN (455-1052): 1.13e-30: 133: 13.54		SUV91_HUMAN (5219-5587): 8.18e-101: 334: 17.89
+	Hs
		728517 ECT2_HUMAN (569-832): 1.95e-43: 173: 16.97		MYH11_HUMAN (3716-4761): 2.82e-67: 257: 9.78
+	Hs
		725246 ECT2_HUMAN (569-832): 1.95e-43: 173: 16.97		MYH10_HUMAN (2953-4079): 9.83e-64: 245: 10.01
+	Hs
		725023 ECT2_HUMAN (569-832): 1.95e-43: 173: 16.97		MYH9_HUMAN (3011-4033): 1.42e-60: 235: 9.78
+	Hs
		164803 SC16A_HUMAN (161-573): 9.2e-27: 120: 14.80		MYH9_HUMAN (3011-4033): 1.42e-60: 235: 9.78
+	Hs
		331812 MDC1_HUMAN (143-1056): 5.13e-53: 205: 13.71		NSD2_HUMAN (165-355): 4.99e-24: 114: 18.14
+	Hs
		1068667 ECT2_HUMAN (569-832): 1.95e-43: 173: 16.97		PLEC_HUMAN (3234-4310): 3.68e-26: 122: 10.96
+	Hs
		1056971 MDC1_HUMAN (143-1056): 5.13e-53: 205: 13.71		SETD2_HUMAN (5440-5587): 1.66e-15: 87: 34.23
+	Hs
		1266895 TOPB1_HUMAN (455-1052): 1.13e-30: 133: 13.54		KMT2B_HUMAN (92-219): 2.29e-24: 116: 27.27
+	Mm
		1351630 PCLO_MOUSE (144-831): 1.01e-37: 156: 11.89		PCLO_MOUSE (4078-4449): 2.34e-12: 76.7: 14.32
+	Hs
		975295 TOPB1_HUMAN (455-1052): 1.13e-30: 133: 13.54		KMT2A_HUMAN (2178-2926): 4.56e-10: 69: 12.34
+	Hs
		152673 TOPB1_HUMAN (455-1052): 1.13e-30: 133: 13.54		KMT2D_HUMAN (115-226): 8.07e-10: 68.3: 31.25
+	Dm
		113976 M9PB30_DROME (150-859): 2.19e-14: 80.5: 8.98		M9PB30_DROME (1615-2379): 4.27e-24: 115: 9.80