Protein: DCNL5
DCN1-like protein 5 (DCNL5) (DCUN1 domain-containing protein 5) (Defective in cullin neddylation protein 1-like protein 5) (Squamous cell carcinoma-related oncogene 5)

Gene: DCNL5, DCUN1D5
Organism: Homo sapiens
Interactions: 74
UniProt ID: Q9BTE7

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0001558 - regulation of cell growth
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005819 - spindle

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1114161

CUL3
Cullin-3

4

20

Small-scale

0.906

High

1112694

CUL1
Cullin-1

3

20

Small-scale

0.847

High

1371853

CUL5
Cullin-5

3

20

Small-scale

0.847

High

1112977

CUL2
Cullin-2

4

20

Small-scale

0.796

High

1115036

CUL4A
Cullin-4A

2

20

Small-scale

0.789

High

1115393

CUL4B
Cullin-4B

2

20

Small-scale

0.789

High

983957

RBX1
E3 ubiquitin-protein ligase RBX1

2

9

Small-scale

0.754

High

957498

UBC12
NEDD8-conjugating enzyme Ubc12

4

10

Small-scale

0.686

High

476020

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

3

0

High-throughput

0.638

High

1158172

MK14
Mitogen-activated protein kinase 14

3

0

High-throughput

0.638

High

1291174

CAND1
Cullin-associated NEDD8-dissociated protein 1

2

4

Small-scale

0.624

High

1413519

RBX2
RING-box protein 2

1

9

Small-scale

0.618

High

1201883

PKHG4
Puratrophin-1

2

1

High-throughput

0.606

High

1326217

PNKD
Probable thioesterase PNKD

2

0

High-throughput

0.585

High

261736

HUS1
Checkpoint protein HUS1

2

0

High-throughput

0.580

High

1413515

PICK1
PRKCA-binding protein

2

0

High-throughput

0.580

High

1348468

LNX1
E3 ubiquitin-protein ligase LNX

1

3

High-throughput

0.573

High

945726

FOXL2
Forkhead box protein L2

1

1

High-throughput

0.536

High

1091342

FOXL1
Forkhead box protein L1

1

1

High-throughput

0.536

High

1399835

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

0

High-throughput

0.518

High

155127

SOCS2
Suppressor of cytokine signaling 2

1

3

High-throughput

0.515

High

156076

SOCS6
Suppressor of cytokine signaling 6

1

3

High-throughput

0.515

High

303694

JTB
Protein JTB

1

0

High-throughput

0.513

High

1023610

CYC
Cytochrome c

1

0

High-throughput

0.513

High

1150249

TEAD2
Transcriptional enhancer factor TEF-4

1

0

High-throughput

0.513

High

1252772

RN111
E3 ubiquitin-protein ligase Arkadia

1

0

High-throughput

0.513

High

1310361

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1383834

EFMT3
EEF1A lysine methyltransferase 3

1

0

High-throughput

0.513

High

1413513

GSX1
GS homeobox 1

1

0

High-throughput

0.513

High

1380509

UBE2F
NEDD8-conjugating enzyme UBE2F

1

10

Small-scale

0.501

High

810333

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.493

High

1068297

AHNK
Neuroblast differentiation-associated protein AHNAK

1

0

High-throughput

0.493

High

1369688

KLK6
Kallikrein-6

1

0

High-throughput

0.493

High

209102

CYB5B
Cytochrome b5 type B

1

1

High-throughput

0.489

High

177936

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

0

Small-scale

0.480

High

242765

PRKN
E3 ubiquitin-protein ligase parkin

1

3

High-throughput

0.479

High

589561

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

674308

BRD2
Bromodomain-containing protein 2

1

2

High-throughput

0.479

High

696368

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

971004

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

998753

H31
Histone H3.1

1

3

High-throughput

0.479

High

1017174

H33
Histone H3.3

1

3

High-throughput

0.479

High

1157898

DDB1
DNA damage-binding protein 1

1

1

Small-scale

0.479

High

1413518

HECW2
E3 ubiquitin-protein ligase HECW2

1

1

High-throughput

0.479

High

611317

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

0

High-throughput

0.458

High

925969

TCP4
Activated RNA polymerase II transcriptional coactivator p15

1

0

High-throughput

0.458

High

1334851

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

1363083

DDB2
DNA damage-binding protein 2

1

0

High-throughput

0.458

High

1386553

OPTN
Optineurin

1

0

High-throughput

0.458

High

769039

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

1246960

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.437

High

1413514

PACC1
Proton-activated chloride channel

2

0

High-throughput

0.328

High

332699

LYPD3
Ly6/PLAUR domain-containing protein 3

2

0

High-throughput

0.318

High

1322717

F177A
Protein FAM177A1

2

0

High-throughput

0.318

High

60221

TM213
Transmembrane protein 213

1

0

High-throughput

0.279

Low

376637

TGFA
Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha

1

0

High-throughput

0.279

Low

388287

GLPA
Glycophorin-A

1

0

High-throughput

0.279

Low

749267

CD70
CD70 antigen

1

0

High-throughput

0.279

Low

867389

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.279

Low

1101647

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

0

High-throughput

0.279

Low

1132577

FXYD3
FXYD domain-containing ion transport regulator 3

1

0

High-throughput

0.279

Low

1187914

KR197
Keratin-associated protein 19-7

1

0

High-throughput

0.279

Low

1249787

ELAP1
Endosome/lysosome-associated apoptosis and autophagy regulator 1

1

0

High-throughput

0.279

Low

1384722

I27L1
Interferon alpha-inducible protein 27-like protein 1

1

0

High-throughput

0.279

Low

1396077

COX42
Cytochrome c oxidase subunit 4 isoform 2, mitochondrial

1

0

High-throughput

0.279

Low

1413516

FGOP2
FGFR1 oncogene partner 2

1

0

High-throughput

0.279

Low

1413517

ORML1
ORM1-like protein 1

1

0

High-throughput

0.279

Low

1413520

CC018
Uncharacterized protein C3orf18

1

0

High-throughput

0.279

Low

1413521

FIS1
Mitochondrial fission 1 protein

1

0

High-throughput

0.279

Low

1124033

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

0

High-throughput

0.268

Low

888550

ACADV
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial

1

0

Small-scale

0.249

Low

1226511

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.249

Low

171565

S27A2
Long-chain fatty acid transport protein 2

1

0

High-throughput

0.232

Low

1293898

VSIG1
V-set and immunoglobulin domain-containing protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025