HitPredict

Interactor 1: MED27 (Q6P2C8)
Mediator of RNA polymerase II transcription subunit 27 (Cofactor required for Sp1 transcriptional activation subunit 8) (CRSP complex subunit 8) (Mediator complex subunit 27) (P37 TRAP/SMCC/PC2 subunit) (Transcriptional coactivator CRSP34)
Gene: MED27

Interactor 2: MED20 (Q9H944)
Mediator of RNA polymerase II transcription subunit 20 (Mediator complex subunit 20) (TRF-proximal protein homolog) (hTRFP)
Gene: MED20

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	1.00	0.930

The method score is based on:

Property	Details
Experiments	25281560, 24981860, 33961781, 35271311, 24882805
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	Med20~Med27
Common GO terms	GO:0003713 - transcription coactivator activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0016592 - mediator complex and 4 others more... GO:0032968 - positive regulation of transcription elongation by RNA polymerase II GO:0051123 - RNA polymerase II preinitiation complex assembly GO:0060261 - positive regulation of transcription initiation by RNA polymerase II GO:0070847 - core mediator complex
Homologous interactions	1

Homologous interactions

Color coding for hit scores

	1	311
Hs

1	212

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024