Interactor 1: PRP8 (Q6P2Q9)
Pre-mRNA-processing-splicing factor 8 (220 kDa U5 snRNP-specific protein) (PRP8 homolog) (Splicing factor Prp8) (p220)
Gene: PRPF8

Interactor 2: PRP8 (Q6P2Q9)
Pre-mRNA-processing-splicing factor 8 (220 kDa U5 snRNP-specific protein) (PRP8 homolog) (Splicing factor Prp8) (p220)
Gene: PRPF8

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.68 0.90 0.785

The method score is based on:

Property Details
Experiments 17317632, 28515276, 16723661
Identification Methods two hybrid, affinity chromatography technology
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains JAB~JAB, JAB~PROCT, JAB~PRP8_domainIV, PRO8NT~PROCN, PROCN~RRM_4, PROCN~U5_2-snRNA_bdg, PROCN~U6-snRNA_bdg, PROCT~PRP8_domainIV, PRP8_domainIV~PRP8_domainIV, PRP8_domainIV~U6-snRNA_bdg, RRM_4~U6-snRNA_bdg, U5_2-snRNA_bdg~U6-snRNA_bdg, U6-snRNA_bdg~U6-snRNA_bdg
Common GO terms GO:0000244 - spliceosomal tri-snRNP complex assembly
GO:0000375 - RNA splicing, via transesterification reactions
GO:0000398 - mRNA splicing, via spliceosome
GO:0003723 - RNA binding
GO:0005634 - nucleus
and 19 others

more...

Homologous interactions 0

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Last updated: 15 Jul 2024