Protein: LIGO1
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 (Leucine-rich repeat and immunoglobulin domain-containing protein 1) (Leucine-rich repeat neuronal protein 1) (Leucine-rich repeat neuronal protein 6A)

Gene: LIGO1, LINGO1
Organism: Homo sapiens
Interactions: 61
UniProt ID: Q96FE5

Gene Ontology (top 5):
GO:0005154 - epidermal growth factor receptor binding
GO:0005615 - extracellular space
GO:0005886 - plasma membrane
GO:0031012 - extracellular matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1273096

LIGO2
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2

3

17

High-throughput

0.861

High

1245260

LRFN4
Leucine-rich repeat and fibronectin type-III domain-containing protein 4

2

18

High-throughput

0.811

High

1294972

LRC33
Transforming growth factor beta activator LRRC33

2

20

High-throughput

0.811

High

654548

FBLN1
Fibulin-1

2

4

High-throughput

0.783

High

1390505

NTRI
Neurotrimin

2

9

High-throughput

0.783

High

1390500

RTN4R
Reticulon-4 receptor

2

20

Small-scale

0.754

High

1390498

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

2

High-throughput

0.698

High

1157028

NTRK3
NT-3 growth factor receptor

1

20

High-throughput

0.691

High

1390507

CLC4A
C-type lectin domain family 4 member A

1

16

High-throughput

0.691

High

1390511

ST14
Suppressor of tumorigenicity 14 protein

1

12

High-throughput

0.691

High

1143770

PON2
Serum paraoxonase/arylesterase 2

3

2

High-throughput

0.667

High

377685

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.656

High

466587

TNR16
Tumor necrosis factor receptor superfamily member 16

3

2

Small-scale

0.640

High

1390510

PCDBB
Protocadherin beta-11

2

3

High-throughput

0.628

High

342642

LY86
Lymphocyte antigen 86

1

1

High-throughput

0.618

High

1177861

CL12B
C-type lectin domain family 12 member B

1

13

High-throughput

0.618

High

363706

EGFR
Epidermal growth factor receptor

1

20

Small-scale

0.618

High

1390492

LIGO1
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1

1

18

Small-scale

0.618

High

422857

A4
Amyloid-beta precursor protein

2

3

Small-scale

0.611

High

1331187

F241A
Uncharacterized protein FAM241A

3

1

High-throughput

0.604

High

1390501

LMA2L
VIP36-like protein

3

1

High-throughput

0.604

High

127386

LEG8
Galectin-8

2

7

High-throughput

0.601

High

1359850

SC5AB
Sodium/myo-inositol cotransporter 2

2

0

High-throughput

0.595

High

220291

FRS3
Fibroblast growth factor receptor substrate 3

2

0

High-throughput

0.580

High

164415

NRP1
Neuropilin-1

1

1

High-throughput

0.575

High

1249942

LRRN1
Leucine-rich repeat neuronal protein 1

1

20

High-throughput

0.575

High

1330166

CC185
Coiled-coil domain-containing protein 185

2

3

High-throughput

0.558

High

685925

KRA59
Keratin-associated protein 5-9

2

10

High-throughput

0.553

High

1327710

MACOI
Macoilin

2

6

High-throughput

0.553

High

1390499

KRA92
Keratin-associated protein 9-2

2

7

High-throughput

0.553

High

1390503

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

2

2

High-throughput

0.553

High

351583

FBLN4
EGF-containing fibulin-like extracellular matrix protein 2

1

4

High-throughput

0.541

High

465858

MSMB
Beta-microseminoprotein

1

1

High-throughput

0.536

High

518890

CCL3
C-C motif chemokine 3

1

3

High-throughput

0.536

High

530213

TAU
Microtubule-associated protein tau

1

2

High-throughput

0.536

High

1390497

C1QT7
Complement C1q tumor necrosis factor-related protein 7

1

2

High-throughput

0.536

High

1390509

S27A6
Long-chain fatty acid transport protein 6

1

8

High-throughput

0.536

High

572126

TRI27
Zinc finger protein RFP

1

1

High-throughput

0.523

High

1063515

GOGA2
Golgin subfamily A member 2

1

5

High-throughput

0.523

High

1390494

SPAG5
Sperm-associated antigen 5

1

6

High-throughput

0.523

High

1159167

SGCB
Beta-sarcoglycan

1

0

High-throughput

0.513

High

1380077

FBXW7
F-box/WD repeat-containing protein 7

1

1

High-throughput

0.494

High

1390495

KR412
Keratin-associated protein 4-12

1

7

High-throughput

0.494

High

976848

LCN6
Epididymal-specific lipocalin-6

1

1

High-throughput

0.489

High

1390496

CNPY3
Protein canopy homolog 3

1

12

High-throughput

0.489

High

1390504

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

2

High-throughput

0.489

High

1390506

FBX2
F-box only protein 2

1

11

High-throughput

0.489

High

1322939

CXD3
Gap junction delta-3 protein

1

2

High-throughput

0.479

High

480879

LEG1
Galectin-1

1

7

High-throughput

0.445

High

726690

SDC4
Syndecan-4

1

1

High-throughput

0.445

High

949759

KR101
Keratin-associated protein 10-1

1

9

High-throughput

0.439

High

1390502

DJC25
DnaJ homolog subfamily C member 25

1

5

High-throughput

0.437

High

120

A0A024R161
Guanine nucleotide-binding protein subunit gamma

1

5

High-throughput

0.407

High

252783

AP180
Clathrin coat assembly protein AP180

1

1

High-throughput

0.407

High

1381304

PSMG2
Proteasome assembly chaperone 2

3

0

High-throughput

0.345

High

1390493

NGLY1
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

3

0

High-throughput

0.345

High

1162863

H2A2C
Histone H2A type 2-C

2

0

High-throughput

0.328

High

1235840

KRA56
Keratin-associated protein 5-6

2

0

High-throughput

0.316

High

1390508

POMP
Proteasome maturation protein

2

0

High-throughput

0.313

High

106451

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025