HitPredict

Interactor 1: TRI40 (Q6P9F5)
E3 ubiquitin ligase TRIM40 (EC 2.3.2.27) (Probable E3 NEDD8-protein ligase) (RING finger protein 35)
Gene: TRIM40

Interactor 2: NEMO (Q9Y6K9)
NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
Gene: IKBKG

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	21474709
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0008385 - IkappaB kinase complex GO:0045087 - innate immune response
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 258 Hs			1 419
+	Hs
		1223395 TRI22_HUMAN (2-258): 1.4e-53: 182: 20.78		NEMO_HUMAN (1-419): 1.12e-52: 183: 100.00
+	Hs
		1318722 TRIM5_HUMAN (5-258): 6.92e-54: 182: 21.15		NEMO_HUMAN (1-419): 1.12e-52: 183: 100.00
+	Hs
		1019390 TRI26_HUMAN (4-242): 4.42e-50: 173: 23.53		NEMO_HUMAN (1-419): 1.12e-52: 183: 100.00
+	Hs
		1318539 TRI31_HUMAN (5-256): 1.2e-43: 154: 25.98		NEMO_HUMAN (1-419): 1.12e-52: 183: 100.00
+	Hs
		585030 RO52_HUMAN (5-258): 1.52e-52: 178: 21.86		OPTN_HUMAN (67-418): 2.78e-38: 147: 27.25
+	Hs
		1078906 TRIM5_HUMAN (5-258): 6.92e-54: 182: 21.15		ITSN1_HUMAN (24-403): 1.07e-30: 127: 12.15
+	Hs
		522639 TRIM6_HUMAN (3-258): 1.1e-55: 187: 22.97		MYH7_HUMAN (26-376): 1.58e-09: 62.3: 13.24
+	Hs
		528393 TRIM6_HUMAN (3-258): 1.1e-55: 187: 22.97		MYH6_HUMAN (4-395): 1.4e-09: 62.3: 11.48
+	Hs
		1261138 TRI41_HUMAN (70-237): 5.26e-09: 58.2: 26.01		NEMO_HUMAN (1-419): 1.12e-52: 183: 100.00
+	Hs
		725005 TRI31_HUMAN (5-256): 1.2e-43: 154: 25.98		MYH9_HUMAN (11-402): 4.5e-11: 67.3: 9.93
+	Hs
		725238 TRI31_HUMAN (5-256): 1.2e-43: 154: 25.98		MYH10_HUMAN (27-387): 1.16e-10: 65.8: 14.09
+	Hs
		1357714 TRI35_HUMAN (4-245): 9.68e-41: 148: 16.30		MRCKB_HUMAN (39-356): 2.85e-10: 64.7: 13.60
+	Mm
		1093546 TRI72_MOUSE (8-242): 1.17e-40: 147: 20.64		MYH9_MOUSE (18-363): 2.99e-10: 64.6: 13.75
+	Hs
		724886 TRI72_HUMAN (8-242): 1.77e-38: 141: 20.64		MYH9_HUMAN (11-402): 4.5e-11: 67.3: 9.93