Protein: SPF30
Survival of motor neuron-related-splicing factor 30 (30 kDa splicing factor SMNrp) (SMN-related protein) (Survival motor neuron domain-containing protein 1)

Gene: SPF30, SMNDC1
Organism: Homo sapiens
Interactions: 96
UniProt ID: O75940

Gene Ontology (top 5):
GO:0000375 - RNA splicing, via transesterification reactions
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005681 - spliceosomal complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

298510

SF3B2
Splicing factor 3B subunit 2

3

1

High-throughput

0.662

High

285746

SF3B1
Splicing factor 3B subunit 1

3

0

High-throughput

0.643

High

298520

SF3A1
Splicing factor 3A subunit 1

2

1

High-throughput

0.628

High

298519

SF3A2
Splicing factor 3A subunit 2

3

0

Small-scale

0.628

High

298484

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

2

3

Small-scale

0.611

High

298513

RBM39
RNA-binding protein 39

2

3

High-throughput

0.611

High

298505

EWS
RNA-binding protein EWS

2

6

High-throughput

0.601

High

298507

SF3A3
Splicing factor 3A subunit 3

2

0

High-throughput

0.595

High

298472

RECQ4
ATP-dependent DNA helicase Q4

2

5

High-throughput

0.584

High

298473

MYC
Myc proto-oncogene protein

2

1

High-throughput

0.584

High

215002

PRPF3
U4/U6 small nuclear ribonucleoprotein Prp3

1

0

High-throughput

0.549

High

175551

SR140
U2 snRNP-associated SURP motif-containing protein

1

4

High-throughput

0.536

High

298479

SNRPA
U1 small nuclear ribonucleoprotein A

1

4

High-throughput

0.536

High

298480

RU1C
U1 small nuclear ribonucleoprotein C

1

1

High-throughput

0.536

High

298482

POTEI
POTE ankyrin domain family member I

1

1

High-throughput

0.536

High

298499

RUXF
Small nuclear ribonucleoprotein F

1

6

High-throughput

0.536

High

298512

CUL3
Cullin-3

1

1

High-throughput

0.536

High

298496

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.527

High

298533

ARHGJ
Rho guanine nucleotide exchange factor 19

2

3

High-throughput

0.521

High

298486

NUCL
Nucleolin

1

1

High-throughput

0.515

High

298518

SF3B4
Splicing factor 3B subunit 4

1

5

High-throughput

0.515

High

298549

DDX21
Nucleolar RNA helicase 2

1

5

High-throughput

0.515

High

271385

ATG13
Autophagy-related protein 13

1

0

High-throughput

0.513

High

298485

IDE
Insulin-degrading enzyme

1

0

High-throughput

0.513

High

298511

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

0

High-throughput

0.513

High

298527

NAA35
N-alpha-acetyltransferase 35, NatC auxiliary subunit

1

0

High-throughput

0.513

High

298493

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.493

High

298517

SF3B3
Splicing factor 3B subunit 3

1

0

High-throughput

0.493

High

298524

TSR1
Pre-rRNA-processing protein TSR1 homolog

1

0

High-throughput

0.493

High

298541

CK5P3
CDK5 regulatory subunit-associated protein 3

1

0

High-throughput

0.493

High

298547

MRM3
rRNA methyltransferase 3, mitochondrial

1

0

High-throughput

0.493

High

298548

SSF1
Suppressor of SWI4 1 homolog

1

0

High-throughput

0.493

High

298555

RUVB1
RuvB-like 1

1

0

High-throughput

0.493

High

298554

PRP19
Pre-mRNA-processing factor 19

1

4

High-throughput

0.481

High

259232

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.479

High

289382

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

1

4

Small-scale

0.479

High

292952

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.479

High

298474

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

1

High-throughput

0.479

High

298475

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.479

High

298476

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

298478

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

2

High-throughput

0.479

High

298481

RU2A
U2 small nuclear ribonucleoprotein A'

1

3

High-throughput

0.479

High

298487

DNJB1
DnaJ homolog subfamily B member 1

1

1

High-throughput

0.479

High

298489

PHB1
Prohibitin 1

1

1

High-throughput

0.479

High

298491

BRCA1
Breast cancer type 1 susceptibility protein

1

1

High-throughput

0.479

High

298492

COIL
Coilin

1

1

High-throughput

0.479

High

298494

RECQ1
ATP-dependent DNA helicase Q1

1

5

High-throughput

0.479

High

298495

MAPK2
MAP kinase-activated protein kinase 2

1

1

High-throughput

0.479

High

298497

MECP2
Methyl-CpG-binding protein 2

1

2

High-throughput

0.479

High

298498

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

298501

H4
Histone H4

1

1

High-throughput

0.479

High

298502

H2B1C
Histone H2B type 1-C/E/F/G/I

1

1

High-throughput

0.479

High

298503

H31
Histone H3.1

1

3

High-throughput

0.479

High

298504

VIGLN
Vigilin

1

6

High-throughput

0.479

High

298514

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

1

High-throughput

0.479

High

298515

IMB1
Importin subunit beta-1

1

2

Small-scale

0.479

High

298516

TNIP1
TNFAIP3-interacting protein 1

1

2

High-throughput

0.479

High

298521

ITSN1
Intersectin-1

1

2

High-throughput

0.479

High

298526

HABP4
Intracellular hyaluronan-binding protein 4

1

3

High-throughput

0.479

High

298529

ASXL2
Putative Polycomb group protein ASXL2

1

1

High-throughput

0.479

High

298530

ZCH18
Zinc finger CCCH domain-containing protein 18

1

1

High-throughput

0.479

High

298536

SERB1
SERPINE1 mRNA-binding protein 1

1

3

High-throughput

0.479

High

298540

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.479

High

298542

DDX50
ATP-dependent RNA helicase DDX50

1

4

High-throughput

0.479

High

298544

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

1

High-throughput

0.479

High

298545

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.479

High

298551

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

298552

WWC3
Protein WWC3

1

3

High-throughput

0.479

High

298553

FZR1
Fizzy-related protein homolog

1

3

High-throughput

0.479

High

298557

SF3B6
Splicing factor 3B subunit 6

1

5

High-throughput

0.479

High

298559

TRRAP
Transformation/transcription domain-associated protein

1

1

High-throughput

0.479

High

298477

PGK2
Phosphoglycerate kinase 2

1

0

High-throughput

0.458

High

298500

RS6
Small ribosomal subunit protein eS6

1

0

High-throughput

0.458

High

298509

CBX3
Chromobox protein homolog 3

1

0

High-throughput

0.458

High

298534

PDCD7
Programmed cell death protein 7

1

0

High-throughput

0.458

High

298538

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.458

High

298539

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

298543

GNL3
Guanine nucleotide-binding protein-like 3

1

0

High-throughput

0.458

High

298550

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

298558

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

298483

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.445

High

298488

BMI1
Polycomb complex protein BMI-1

1

3

High-throughput

0.445

High

298546

LN28A
Protein lin-28 homolog A

1

1

High-throughput

0.445

High

156786

CTRO
Citron Rho-interacting kinase

1

1

High-throughput

0.437

High

298506

LMNB2
Lamin-B2

1

1

High-throughput

0.437

High

298508

IFT88
Intraflagellar transport protein 88 homolog

1

1

High-throughput

0.437

High

298528

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.437

High

298537

PREX1
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

1

3

High-throughput

0.437

High

298556

NINL
Ninein-like protein

1

1

High-throughput

0.437

High

298525

NCBP3
Nuclear cap-binding protein subunit 3

1

0

High-throughput

0.426

High

298531

S2611
Sodium-independent sulfate anion transporter

1

0

High-throughput

0.426

High

298523

H31T
Histone H3.1t

1

3

Small-scale

0.408

High

298532

LDHD
Probable D-lactate dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

298535

GPT11
G patch domain-containing protein 11

1

0

High-throughput

0.279

Low

298490

FDFT
Squalene synthase

1

0

High-throughput

0.269

Low

298522

UT2
Urea transporter 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025