HitPredict

Interactor 1: CXL17 (Q6UXB2)
C-X-C motif chemokine 17 (6-Cys CXCL17) (Dendritic cell and monocyte chemokine-like protein) (DMC) (VEGF coregulated chemokine 1) [Cleaved into: 4-Cys CXCL17]
Gene: CXCL17

Interactor 2: CCL17 (Q92583)
C-C motif chemokine 17 (CC chemokine TARC) (Small-inducible cytokine A17) (Thymus and activation-regulated chemokine)
Gene: CCL17

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	28381538
Identification Methods	surface plasmon resonance
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005615 - extracellular space GO:0070374 - positive regulation of ERK1 and ERK2 cascade
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 119 Hs			1 94
+	Hs
		1166407 CXL17_HUMAN (1-119): 5.21e-77: 224: 100.00		CCL13_HUMAN (6-94): 5.69e-34: 113: 29.21
+	Hs
		945620 CXL17_HUMAN (1-119): 5.21e-77: 224: 100.00		CCL8_HUMAN (15-94): 8.16e-31: 106: 23.46
+	Hs
		528221 CXL17_HUMAN (1-119): 5.21e-77: 224: 100.00		CCL2_HUMAN (15-94): 6.73e-29: 101: 23.46
+	Hs
		179467 CXL17_HUMAN (1-119): 5.21e-77: 224: 100.00		CCL25_HUMAN (4-93): 4.24e-25: 93.1: 23.96
+	Hs
		1166410 CXL17_HUMAN (1-119): 5.21e-77: 224: 100.00		CCL26_HUMAN (22-93): 3.75e-25: 91.6: 27.78
+	Hs
		528267 CXL17_HUMAN (1-119): 5.21e-77: 224: 100.00		CCL5_HUMAN (14-90): 3.37e-25: 91.6: 25.97
+	Hs
		1166409 CXL17_HUMAN (1-119): 5.21e-77: 224: 100.00		XCL2_HUMAN (4-94): 7.19e-23: 86.6: 23.91
+	Hs
		815515 CXL17_HUMAN (1-119): 5.21e-77: 224: 100.00		XCL1_HUMAN (4-94): 8.75e-23: 86.2: 22.83
+	Hs
		944668 CXL17_HUMAN (1-119): 5.21e-77: 224: 100.00		CCL20_HUMAN (8-94): 1.49e-20: 80: 22.47
+	Hs
		134308 CXL17_HUMAN (1-119): 5.21e-77: 224: 100.00		CCL21_HUMAN (30-93): 4.84e-18: 74.6: 25.00