Protein: SYT6
Synaptotagmin-6 (Synaptotagmin VI) (SytVI)

Gene: SYT6
Organism: Homo sapiens
Interactions: 123
UniProt ID: Q5T7P8

Gene Ontology (top 5):
GO:0000149 - SNARE binding
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0007268 - chemical synaptic transmission
GO:0009898 - cytoplasmic side of plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1214343

SYT10
Synaptotagmin-10

3

15

High-throughput

0.861

High

1214368

SYT3
Synaptotagmin-3

3

15

High-throughput

0.861

High

463124

YES
Tyrosine-protein kinase Yes

1

1

High-throughput

0.691

High

1053678

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

3

High-throughput

0.691

High

1214391

JAM1
Junctional adhesion molecule A

1

4

High-throughput

0.691

High

900369

FXR2
RNA-binding protein FXR2

3

4

High-throughput

0.675

High

1063318

GOGA2
Golgin subfamily A member 2

3

5

High-throughput

0.675

High

1093364

TRI32
E3 ubiquitin-protein ligase TRIM32

3

3

High-throughput

0.675

High

1214352

DVL3
Segment polarity protein dishevelled homolog DVL-3

3

2

High-throughput

0.675

High

1214351

MADD
MAP kinase-activating death domain protein

3

4

High-throughput

0.667

High

1214359

SAHH3
Adenosylhomocysteinase 3

3

3

High-throughput

0.667

High

1214338

TENS2
Tensin-2

1

0

High-throughput

0.630

High

1214337

SYT6
Synaptotagmin-6

1

14

Small-scale

0.618

High

212845

ZBT43
Zinc finger and BTB domain-containing protein 43

3

5

High-throughput

0.616

High

1214345

KCTD9
BTB/POZ domain-containing protein KCTD9

3

4

High-throughput

0.616

High

436681

KPCB
Protein kinase C beta type

1

0

Small-scale

0.614

High

572013

TRI27
Zinc finger protein RFP

2

3

High-throughput

0.606

High

659502

CRCM
Colorectal mutant cancer protein

2

3

High-throughput

0.606

High

899959

FXR1
RNA-binding protein FXR1

2

4

High-throughput

0.606

High

1214069

KIF24
Kinesin-like protein KIF24

2

1

High-throughput

0.606

High

1214348

CNTRB
Centrobin

2

5

High-throughput

0.606

High

1214358

HOOK2
Protein Hook homolog 2

2

3

High-throughput

0.606

High

1214385

LZTS1
Leucine zipper putative tumor suppressor 1

2

7

High-throughput

0.606

High

1214393

MD1L1
Mitotic spindle assembly checkpoint protein MAD1

2

4

High-throughput

0.606

High

422291

A4
Amyloid-beta precursor protein

2

8

High-throughput

0.602

High

1214341

HMBX1
Homeobox-containing protein 1

2

0

High-throughput

0.580

High

1137762

TNIP1
TNFAIP3-interacting protein 1

1

3

High-throughput

0.573

High

1205816

MTUS2
Microtubule-associated tumor suppressor candidate 2

1

3

High-throughput

0.573

High

1179955

CCD57
Coiled-coil domain-containing protein 57

2

3

High-throughput

0.553

High

1214339

KANK2
KN motif and ankyrin repeat domain-containing protein 2

2

3

High-throughput

0.553

High

1214360

GMCL1
Germ cell-less protein-like 1

2

4

High-throughput

0.553

High

1214370

KIFC3
Kinesin-like protein KIFC3

2

2

High-throughput

0.553

High

1214340

K1C40
Keratin, type I cytoskeletal 40

1

0

High-throughput

0.549

High

230036

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

3

High-throughput

0.536

High

255814

USO1
General vesicular transport factor p115

1

3

High-throughput

0.536

High

272680

BRE1B
E3 ubiquitin-protein ligase BRE1B

1

3

High-throughput

0.536

High

280658

PR40A
Pre-mRNA-processing factor 40 homolog A

1

2

High-throughput

0.536

High

611166

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

3

High-throughput

0.536

High

691770

MK03
Mitogen-activated protein kinase 3

1

1

High-throughput

0.536

High

719943

HMOX2
Heme oxygenase 2

1

1

High-throughput

0.536

High

957944

RAB14
Ras-related protein Rab-14

1

4

High-throughput

0.536

High

959343

RAP1B
Ras-related protein Rap-1b

1

10

High-throughput

0.536

High

1116957

CD166
CD166 antigen

1

2

High-throughput

0.536

High

1154488

STXB2
Syntaxin-binding protein 2

1

1

High-throughput

0.536

High

1154641

VAMP3
Vesicle-associated membrane protein 3

1

4

High-throughput

0.536

High

1214342

EDC4
Enhancer of mRNA-decapping protein 4

1

1

High-throughput

0.536

High

1214355

ARL8A
ADP-ribosylation factor-like protein 8A

1

4

High-throughput

0.536

High

1214367

VRK1
Serine/threonine-protein kinase VRK1

1

2

High-throughput

0.536

High

1214371

NAA15
N-alpha-acetyltransferase 15, NatA auxiliary subunit

1

3

High-throughput

0.536

High

1214374

RAB1B
Ras-related protein Rab-1B

1

9

High-throughput

0.536

High

1214382

RAB21
Ras-related protein Rab-21

1

12

High-throughput

0.536

High

1214392

SAR1B
Small COPII coat GTPase SAR1B

1

7

High-throughput

0.536

High

1214356

ZBT8A
Zinc finger and BTB domain-containing protein 8A

1

5

High-throughput

0.523

High

1214372

TSG10
Testis-specific gene 10 protein

1

6

High-throughput

0.523

High

843644

HD
Huntingtin

1

9

High-throughput

0.515

High

1090702

TRAF2
TNF receptor-associated factor 2

1

2

High-throughput

0.515

High

138835

STK25
Serine/threonine-protein kinase 25

1

0

High-throughput

0.513

High

295833

FACE1
CAAX prenyl protease 1 homolog

1

0

High-throughput

0.513

High

300161

GLRX3
Glutaredoxin-3

1

0

High-throughput

0.513

High

360013

NB5R3
NADH-cytochrome b5 reductase 3

1

0

High-throughput

0.513

High

408918

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

High-throughput

0.513

High

469097

SRPRA
Signal recognition particle receptor subunit alpha

1

0

High-throughput

0.513

High

617444

DNLI1
DNA ligase 1

1

0

High-throughput

0.513

High

627130

TYPH
Thymidine phosphorylase

1

0

High-throughput

0.513

High

877342

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

0

High-throughput

0.513

High

896785

DYN2
Dynamin-2

1

0

High-throughput

0.513

High

903953

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.513

High

934090

XPO2
Exportin-2

1

0

High-throughput

0.513

High

954496

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

0

High-throughput

0.513

High

1024621

VIGLN
Vigilin

1

0

High-throughput

0.513

High

1119819

CKAP5
Cytoskeleton-associated protein 5

1

0

High-throughput

0.513

High

1120452

SCRB2
Lysosome membrane protein 2

1

0

High-throughput

0.513

High

1125972

GALE
UDP-glucose 4-epimerase

1

0

High-throughput

0.513

High

1137224

CND1
Condensin complex subunit 1

1

0

High-throughput

0.513

High

1177568

PDS5A
Sister chromatid cohesion protein PDS5 homolog A

1

0

High-throughput

0.513

High

1186996

TKFC
Triokinase/FMN cyclase

1

0

High-throughput

0.513

High

1214344

SND1
Staphylococcal nuclease domain-containing protein 1

1

0

High-throughput

0.513

High

1214354

F162A
Protein FAM162A

1

0

High-throughput

0.513

High

1214364

VPS35
Vacuolar protein sorting-associated protein 35

1

0

High-throughput

0.513

High

1214365

MIPEP
Mitochondrial intermediate peptidase

1

0

High-throughput

0.513

High

1214366

S29A1
Equilibrative nucleoside transporter 1

1

0

High-throughput

0.513

High

1214373

NAA50
N-alpha-acetyltransferase 50

1

0

High-throughput

0.513

High

1214375

EHD4
EH domain-containing protein 4

1

0

High-throughput

0.513

High

1214376

PGES2
Prostaglandin E synthase 2

1

0

High-throughput

0.513

High

1214378

VTA1
Vacuolar protein sorting-associated protein VTA1 homolog

1

0

High-throughput

0.513

High

1214380

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

0

High-throughput

0.513

High

1214381

CYRIB
CYFIP-related Rac1 interactor B

1

0

High-throughput

0.513

High

1214383

TM11E
Transmembrane protease serine 11E

1

0

High-throughput

0.513

High

1214386

RRP44
Exosome complex exonuclease RRP44

1

0

High-throughput

0.513

High

1214387

GSTK1
Glutathione S-transferase kappa 1

1

0

High-throughput

0.513

High

1214388

PTH2
Peptidyl-tRNA hydrolase 2, mitochondrial

1

0

High-throughput

0.513

High

1214389

VPP2
V-type proton ATPase 116 kDa subunit a 2

1

0

High-throughput

0.513

High

1214390

TNPO3
Transportin-3

1

0

High-throughput

0.513

High

130496

SPT5H
Transcription elongation factor SPT5

1

1

High-throughput

0.489

High

348140

M4K4
Mitogen-activated protein kinase kinase kinase kinase 4

1

3

High-throughput

0.489

High

690508

KAD4
Adenylate kinase 4, mitochondrial

1

1

High-throughput

0.489

High

1152797

NSDHL
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

1

1

High-throughput

0.489

High

1214346

HDGR2
Hepatoma-derived growth factor-related protein 2

1

1

High-throughput

0.489

High

1214384

MCTS1
Malignant T-cell-amplified sequence 1

1

1

High-throughput

0.489

High

385828

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

2

High-throughput

0.481

High

799197

BRCA1
Breast cancer type 1 susceptibility protein

1

2

High-throughput

0.481

High

1141667

EEA1
Early endosome antigen 1

1

5

High-throughput

0.479

High

529943

TAU
Microtubule-associated protein tau

1

8

High-throughput

0.445

High

1214361

CC136
Coiled-coil domain-containing protein 136

1

5

High-throughput

0.439

High

168989

QCR8
Cytochrome b-c1 complex subunit 8

1

0

High-throughput

0.279

Low

329283

LETM1
Mitochondrial proton/calcium exchanger protein

1

0

High-throughput

0.279

Low

851915

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.279

Low

941459

CTBP2
C-terminal-binding protein 2

1

0

High-throughput

0.279

Low

1092322

CSTF3
Cleavage stimulation factor subunit 3

1

0

High-throughput

0.279

Low

1138842

SYLM
Leucine--tRNA ligase, mitochondrial

1

0

High-throughput

0.279

Low

1162363

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.279

Low

1214347

RAVR1
Ribonucleoprotein PTB-binding 1

1

0

High-throughput

0.279

Low

1214349

RDH11
Retinol dehydrogenase 11

1

0

High-throughput

0.279

Low

1214353

FAKD4
FAST kinase domain-containing protein 4

1

0

High-throughput

0.279

Low

1214357

RMD1
Regulator of microtubule dynamics protein 1

1

0

High-throughput

0.279

Low

1214362

TOPK
Lymphokine-activated killer T-cell-originated protein kinase

1

0

High-throughput

0.279

Low

1214363

PUS7
Pseudouridylate synthase 7 homolog

1

0

High-throughput

0.279

Low

1214369

TMM70
Transmembrane protein 70, mitochondrial

1

0

High-throughput

0.279

Low

1214377

SFXN1
Sideroflexin-1

1

0

High-throughput

0.279

Low

1214379

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

1

0

High-throughput

0.279

Low

1214350

AEN
Apoptosis-enhancing nuclease

1

0

High-throughput

0.268

Low

181633

CETN3
Centrin-3

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025