HitPredict

Interactor 1: MPRIP (Q6WCQ1)
Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip)
Gene: MPRIP

Interactor 2: FGD5 (Q6ZNL6)
FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23)
Gene: FGD5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	33762435
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PH, PH~RhoGEF
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1025 Hs			1 1462
+	Hs
		724887 MYH9_HUMAN (540-1015): 1.52e-17: 90.5: 9.66		FGD5_HUMAN (1-1462): 0: 1231: 100.00
+	Hs
		725184 MYH10_HUMAN (534-1014): 3.94e-16: 85.9: 9.18		FGD5_HUMAN (1-1462): 0: 1231: 100.00
+	Hs
		728488 MYH11_HUMAN (124-786): 1.25e-12: 74.7: 11.57		FGD5_HUMAN (1-1462): 0: 1231: 100.00
+	Hs
		1068579 PLEC_HUMAN (499-978): 3.1e-11: 70.1: 14.96		FGD5_HUMAN (1-1462): 0: 1231: 100.00
+	Hs
		1167428 MPRIP_HUMAN (1-1025): 9.29e-127: 412: 100.00		ECT2_HUMAN (887-1207): 1.07e-70: 258: 19.94
+	Hs
		1068638 PLEC_HUMAN (499-978): 3.1e-11: 70.1: 14.96		FGD4_HUMAN (703-1459): 6.54e-142: 455: 22.61
+	Hs
		1153473 PKHA7_HUMAN (336-980): 5.04e-41: 166: 13.51		FARP1_HUMAN (641-1254): 5.14e-83: 298: 20.00
+	Hs
		200789 PKHA5_HUMAN (318-1019): 7.56e-36: 149: 13.24		ARHG9_HUMAN (838-1262): 3.85e-84: 287: 14.51
+	Hs
		1333814 CE164_HUMAN (163-980): 5.02e-36: 150: 11.93		ECT2_HUMAN (887-1207): 1.07e-70: 258: 19.94
+	Hs
		149299 CTRO_HUMAN (195-1019): 1.45e-35: 149: 11.42		ECT2_HUMAN (887-1207): 1.07e-70: 258: 19.94
+	Hs
		1068630 PLEC_HUMAN (499-978): 3.1e-11: 70.1: 14.96		Q96D37_HUMAN (828-1452): 6.85e-95: 326: 14.29
+	Hs
		548710 PLEC_HUMAN (499-978): 3.1e-11: 70.1: 14.96		VAV_HUMAN (828-1452): 2.24e-94: 326: 14.29
+	Hs
		50598 PKHA7_HUMAN (336-980): 5.04e-41: 166: 13.51		PKHG3_HUMAN (895-1222): 7.63e-60: 228: 18.98
+	Hs
		166488 SLK_HUMAN (178-999): 9.15e-17: 87.8: 10.02		MCF2L_HUMAN (504-1254): 9.66e-81: 292: 13.17
+	Hs
		725023 MYH9_HUMAN (540-1015): 1.52e-17: 90.5: 9.66		ECT2_HUMAN (887-1207): 1.07e-70: 258: 19.94
+	Hs
		725246 MYH10_HUMAN (534-1014): 3.94e-16: 85.9: 9.18		ECT2_HUMAN (887-1207): 1.07e-70: 258: 19.94
+	Hs
		728517 MYH11_HUMAN (124-786): 1.25e-12: 74.7: 11.57		ECT2_HUMAN (887-1207): 1.07e-70: 258: 19.94
+	Hs
		1068667 PLEC_HUMAN (499-978): 3.1e-11: 70.1: 14.96		ECT2_HUMAN (887-1207): 1.07e-70: 258: 19.94
+	Hs
		50564 MYH9_HUMAN (540-1015): 1.52e-17: 90.5: 9.66		PKHG3_HUMAN (895-1222): 7.63e-60: 228: 18.98
+	Hs
		724971 MYH9_HUMAN (540-1015): 1.52e-17: 90.5: 9.66		ARHGH_HUMAN (847-1215): 6.93e-46: 184: 18.78