HitPredict

Interactor 1: CERS6 (Q6ZMG9)
Ceramide synthase 6 (CerS6) (LAG1 longevity assurance homolog 6) (Sphingoid base N-palmitoyltransferase CERS6) (EC 2.3.1.291)
Gene: CERS6

Interactor 2: P2Y12 (Q9H244)
P2Y purinoceptor 12 (P2Y12) (ADP-glucose receptor) (ADPG-R) (P2T(AC)) (P2Y(AC)) (P2Y(cyc)) (P2Y12 platelet ADP receptor) (P2Y(ADP)) (SP1999)
Gene: P2RY12

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0016020 - membrane
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 384 Hs			1 342
+	Hs
		849677 CERS6_HUMAN (1-384): 8.88e-163: 463: 100.00		CCR6_HUMAN (16-314): 3.66e-89: 273: 22.88
+	Hs
		849683 CERS5_HUMAN (6-375): 6.65e-154: 440: 64.96		CCR6_HUMAN (16-314): 3.66e-89: 273: 22.88
+	Hs
		723335 CERS6_HUMAN (1-384): 8.88e-163: 463: 100.00		APJ_HUMAN (1-340): 9.92e-70: 224: 22.16
+	Hs
		674858 CERS6_HUMAN (1-384): 8.88e-163: 463: 100.00		AGTR1_HUMAN (21-337): 1.7e-64: 209: 25.55
+	Hs
		781078 CERS6_HUMAN (1-384): 8.88e-163: 463: 100.00		OPRX_HUMAN (13-330): 8.68e-64: 208: 21.56
+	Hs
		1030979 CERS6_HUMAN (1-384): 8.88e-163: 463: 100.00		GPR17_HUMAN (6-333): 1.6e-63: 207: 24.01
+	Hs
		895677 CERS5_HUMAN (6-375): 6.65e-154: 440: 64.96		CXCR4_HUMAN (18-330): 1.17e-71: 228: 22.54
+	Hs
		1234292 CERS5_HUMAN (6-375): 6.65e-154: 440: 64.96		P2Y12_HUMAN (1-342): 3.78e-69: 221: 100.00
+	Hs
		666327 CERS5_HUMAN (6-375): 6.65e-154: 440: 64.96		NK3R_HUMAN (8-342): 1.51e-65: 215: 19.36
+	Hs
		781097 CERS2_HUMAN (7-342): 1.13e-146: 422: 44.64		OPRX_HUMAN (13-330): 8.68e-64: 208: 21.56
+	Hs
		1031047 CERS2_HUMAN (7-342): 1.13e-146: 422: 44.64		GPR17_HUMAN (6-333): 1.6e-63: 207: 24.01
+	Hs
		814578 CERS6_HUMAN (1-384): 8.88e-163: 463: 100.00		P2RY1_HUMAN (28-309): 2.91e-19: 89.4: 24.40
+	Hs
		814586 CERS2_HUMAN (7-342): 1.13e-146: 422: 44.64		P2RY1_HUMAN (28-309): 2.91e-19: 89.4: 24.40