HitPredict

Interactor 1: SGK1 (O00141)
Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1)
Gene: SGK1

Interactor 2: NED4L (Q96PU5)
E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2)
Gene: NEDD4L

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	0.60	0.727

Property	Details
Experiments	19917253, 16716084, 20525693, 20730100, 16006511, 23589291
Identification Methods	enzymatic study, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0015459 - potassium channel regulator activity GO:0017080 - sodium channel regulator activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 431 Hs			1 975
+	Mm
		1208292 SGK1_MOUSE (1-431): 1.64e-175: 499: 96.52		NED4L_MOUSE (17-975): 0: 1014: 98.02
+	Xl
		1151478 SGK1A_XENLA (1-431): 7.82e-174: 495: 90.32		Q6GMD5_XENLA (7-975): 0: 1003: 89.69
+	Hs
		1299664 AKT3_HUMAN (25-426): 4.84e-157: 454: 43.91		NED4L_HUMAN (1-975): 0: 1033: 100.00
+	Hs
		681988 AKT1_HUMAN (25-426): 4.84e-154: 446: 41.57		NED4L_HUMAN (1-975): 0: 1033: 100.00
+	Hs
		1285839 SGK3_HUMAN (27-431): 2.63e-152: 442: 67.64		NED4L_HUMAN (1-975): 0: 1033: 100.00
+	Hs
		1299638 SGK2_HUMAN (65-431): 3.87e-150: 432: 69.48		NED4L_HUMAN (1-975): 0: 1033: 100.00
+	Hs
		1299657 KS6B2_HUMAN (98-429): 6.11e-146: 426: 45.99		NED4L_HUMAN (1-975): 0: 1033: 100.00
+	Mm
		93288 SGK1_MOUSE (1-431): 1.64e-175: 499: 96.52		E9PXB7_MOUSE (122-975): 0: 863: 95.79
+	Hs
		116984 SGK1_HUMAN (1-431): 5.26e-178: 505: 100.00		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		1285838 SGK3_HUMAN (27-431): 2.63e-152: 442: 67.64		ITCH_HUMAN (9-972): 0: 772: 33.16
+	Hs
		808324 AKT3_HUMAN (25-426): 4.84e-157: 454: 43.91		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		681731 AKT1_HUMAN (25-426): 4.84e-154: 446: 41.57		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		808277 SGK2_HUMAN (65-431): 3.87e-150: 432: 69.48		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		616684 KS6B1_HUMAN (91-429): 1.64e-145: 426: 45.35		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		808054 KS6A3_HUMAN (88-368): 4.35e-106: 331: 28.77		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		784035 KPCI_HUMAN (4-426): 7.24e-151: 442: 34.56		HUWE1_HUMAN (358-973): 3.88e-170: 554: 32.26
+	Hs
		408640 KPCB_HUMAN (27-430): 4.08e-146: 433: 37.53		HUWE1_HUMAN (358-973): 3.88e-170: 554: 32.26
+	Hs
		983863 KPCZ_HUMAN (6-426): 2.47e-146: 430: 36.51		HUWE1_HUMAN (358-973): 3.88e-170: 554: 32.26
+	Hs
		784093 KPCI_HUMAN (4-426): 7.24e-151: 442: 34.56		SMUF1_HUMAN (17-499): 1.65e-30: 131: 15.71
+	Hs
		566484 KPCA_HUMAN (27-430): 1.24e-144: 429: 37.32		SMUF1_HUMAN (17-499): 1.65e-30: 131: 15.71