HitPredict

Interactor 1: IKZF4 (Q9H2S9)
Zinc finger protein Eos (Ikaros family zinc finger protein 4)
Gene: IKZF4

Interactor 2: IKZF3 (Q9UKT9)
Zinc finger protein Aiolos (Ikaros family zinc finger protein 3)
Gene: IKZF3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.899

Property	Details
Experiments	26186194, 28514442, 10978333, 33961781
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	zf-C2H2~zf-C2H2
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0003700 - DNA-binding transcription factor activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 585 Hs			1 509
+	Hs
		1356562 IKZF2_HUMAN (66-582): 5.82e-168: 489: 56.11		IKZF2_HUMAN (4-504): 3.73e-144: 426: 46.98
+	Hs
		1033731 IKZF4_HUMAN (1-585): 1.35e-169: 496: 100.00		IKZF1_HUMAN (31-505): 1.69e-140: 416: 55.51
+	Hs
		1033755 IKZF2_HUMAN (66-582): 5.82e-168: 489: 56.11		IKZF1_HUMAN (31-505): 1.69e-140: 416: 55.51
+	Hs
		1329652 IKZF4_HUMAN (1-585): 1.35e-169: 496: 100.00		IKZF4_HUMAN (110-505): 5.69e-135: 404: 50.35
+	Hs
		1033630 IKZF1_HUMAN (70-583): 7.61e-165: 481: 50.87		IKZF1_HUMAN (31-505): 1.69e-140: 416: 55.51
+	Hs
		1356563 IKZF2_HUMAN (66-582): 5.82e-168: 489: 56.11		IKZF3_HUMAN (1-509): 2.04e-134: 400: 100.00
+	Hs
		1033756 IKZF1_HUMAN (70-583): 7.61e-165: 481: 50.87		IKZF3_HUMAN (1-509): 2.04e-134: 400: 100.00
+	Hs
		1356574 IKZF3_HUMAN (61-583): 1.11e-144: 429: 43.02		IKZF3_HUMAN (1-509): 2.04e-134: 400: 100.00
+	Hs
		1329653 IKZF4_HUMAN (1-585): 1.35e-169: 496: 100.00		IKZF5_HUMAN (111-504): 4.95e-87: 275: 23.62
+	Hs
		1332094 IKZF2_HUMAN (66-582): 5.82e-168: 489: 56.11		IKZF5_HUMAN (111-504): 4.95e-87: 275: 23.62
+	Hs
		1033733 IKZF1_HUMAN (70-583): 7.61e-165: 481: 50.87		IKZF5_HUMAN (111-504): 4.95e-87: 275: 23.62
+	Hs
		1332095 IKZF3_HUMAN (61-583): 1.11e-144: 429: 43.02		IKZF5_HUMAN (111-504): 4.95e-87: 275: 23.62
+	Hs
		64162 ZN726_HUMAN (11-367): 1.6e-128: 391: 18.43		ZN430_HUMAN (3-219): 9.31e-63: 216: 24.89
+	Hs
		152714 ZN197_HUMAN (211-585): 3.92e-127: 399: 14.65		ZN397_HUMAN (4-276): 7.84e-60: 207: 22.97
+	Hs
		563279 ZNF7_HUMAN (90-580): 2.01e-130: 398: 14.94		ZNF16_HUMAN (342-508): 9.7e-36: 142: 10.24
+	Hs
		563770 ZNF3_HUMAN (69-371): 1.27e-99: 311: 21.09		ZNF3_HUMAN (3-116): 7.61e-14: 75.6: 13.16