HitPredict

Interactor 1: ANKS3 (Q6ZW76)
Ankyrin repeat and SAM domain-containing protein 3
Gene: ANKS3

Interactor 2: NEK8 (Q86SG6)
Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (Nima-related protein kinase 12a)
Gene: NEK8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	27173435, 33961781
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank_2~Pkinase, Ank_4~Pkinase, Pkinase~SAM_1
Common GO terms	GO:0005737 - cytoplasm GO:0005929 - cilium
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 656 Hs			1 692
+	Mm
		292549 INVS_MOUSE (27-443): 9.48e-42: 165: 15.22		NEK8_MOUSE (1-692): 0: 702: 92.84
+	Mm
		57434 A2AM57_MOUSE (27-443): 9.92e-42: 165: 15.22		NEK8_MOUSE (1-692): 0: 702: 92.84
+	Hs
		647851 DAPK1_HUMAN (1-397): 9.92e-65: 234: 15.80		MARK3_HUMAN (3-436): 2.69e-134: 414: 22.60
+	Hs
		1173306 ANKS3_HUMAN (1-656): 3.86e-154: 461: 100.00		NEK7_HUMAN (10-252): 3.63e-51: 181: 40.40
+	Hs
		1173316 ANKS3_HUMAN (1-656): 3.86e-154: 461: 100.00		NEK6_HUMAN (10-252): 1.87e-49: 177: 38.80
+	Hs
		647934 ANKR7_HUMAN (13-96): 1.15e-14: 76.4: 21.43		MARK3_HUMAN (3-436): 2.69e-134: 414: 22.60
+	Mm
		1206668 ANS1B_MOUSE (138-492): 1.82e-20: 98.7: 14.00		KCC2G_MOUSE (2-401): 1.7e-126: 387: 22.06
+	Hs
		60311 POTEF_HUMAN (7-628): 1.9e-71: 252: 17.56		NEK4_HUMAN (1-313): 5.52e-60: 218: 37.14
+	Hs
		166899 ANR28_HUMAN (73-440): 8.56e-48: 183: 16.80		NEK4_HUMAN (1-313): 5.52e-60: 218: 37.14
+	Hs
		70724 POTEC_HUMAN (25-154): 5.47e-23: 105: 26.15		HERC3_HUMAN (278-636): 6.62e-79: 274: 24.55
+	Hs
		851551 POTEE_HUMAN (1-552): 5.78e-28: 122: 13.80		NEK4_HUMAN (1-313): 5.52e-60: 218: 37.14
+	Mm
		1118155 ANK2_MOUSE (3-444): 4.22e-62: 227: 15.97		HERC2_MOUSE (314-460): 2.33e-09: 63.2: 31.68
+	Ce
		107815 Q9U2L2_CAEEL (32-242): 6.19e-24: 106: 34.72		NEKL3_CAEEL (10-253): 2.66e-45: 165: 37.85
+	Hs
		276129 PSD10_HUMAN (43-228): 7.26e-56: 191: 27.42		HERC2_HUMAN (314-460): 2.25e-09: 63.2: 31.68
+	Hs
		1302642 Q96T11_HUMAN (35-121): 3.04e-12: 71.9: 27.59		STK36_HUMAN (1-257): 4.66e-36: 148: 33.85
+	Hs
		1330855 Q9H4D1_HUMAN (35-121): 2.7e-12: 71.9: 27.59		STK36_HUMAN (1-257): 4.66e-36: 148: 33.85