HitPredict

Interactor 1: ANKS3 (Q6ZW76)
Ankyrin repeat and SAM domain-containing protein 3
Gene: ANKS3

Interactor 2: NEK7 (Q8TDX7)
Serine/threonine-protein kinase Nek7 (EC 2.7.11.34) (Never in mitosis A-related kinase 7) (NimA-related protein kinase 7)
Gene: NEK7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.871

Property	Details
Experiments	27173435, 33961781, 32707033
Identification Methods	affinity chromatography technology, tandem affinity purification, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank_2~Pkinase, Ank_4~Pkinase, Pkinase~SAM_1
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 656 Hs			1 302
+	Hs
		1173316 ANKS3_HUMAN (1-656): 3.86e-154: 461: 100.00		NEK6_HUMAN (12-302): 1.58e-139: 397: 81.44
+	Hs
		1173303 ANKS3_HUMAN (1-656): 3.86e-154: 461: 100.00		NEK8_HUMAN (40-288): 1.58e-51: 181: 40.40
+	Rn
		1144333 CSKI1_RAT (5-496): 4.09e-71: 252: 19.74		AKT3_RAT (2-294): 1.41e-124: 366: 23.43
+	Hs
		160648 MIB1_HUMAN (5-436): 1.51e-58: 214: 16.13		AURKA_HUMAN (2-301): 1.63e-118: 348: 26.30
+	Ce
		107815 Q9U2L2_CAEEL (32-242): 6.19e-24: 106: 34.72		NEKL3_CAEEL (24-296): 6.34e-128: 368: 73.99
+	Hs
		60311 POTEF_HUMAN (7-628): 1.9e-71: 252: 17.56		NEK4_HUMAN (31-285): 1.86e-53: 188: 40.23
+	Hs
		883501 RIPK4_HUMAN (35-121): 2.51e-12: 72.3: 27.59		STK3_HUMAN (8-301): 3.15e-120: 355: 28.14
+	Hs
		1027432 Q9H4D1_HUMAN (35-121): 2.7e-12: 71.9: 27.59		STK3_HUMAN (8-301): 3.15e-120: 355: 28.14
+	Hs
		166899 ANR28_HUMAN (73-440): 8.56e-48: 183: 16.80		NEK4_HUMAN (31-285): 1.86e-53: 188: 40.23
+	Mm
		292549 INVS_MOUSE (27-443): 9.48e-42: 165: 15.22		NEK8_MOUSE (40-288): 1.26e-51: 182: 40.80
+	Mm
		57434 A2AM57_MOUSE (27-443): 9.92e-42: 165: 15.22		NEK8_MOUSE (40-288): 1.26e-51: 182: 40.80
+	Hs
		851551 POTEE_HUMAN (1-552): 5.78e-28: 122: 13.80		NEK4_HUMAN (31-285): 1.86e-53: 188: 40.23
+	Hs
		1302642 Q96T11_HUMAN (35-121): 3.04e-12: 71.9: 27.59		STK36_HUMAN (31-287): 3.02e-37: 142: 33.72
+	Hs
		1330855 Q9H4D1_HUMAN (35-121): 2.7e-12: 71.9: 27.59		STK36_HUMAN (31-287): 3.02e-37: 142: 33.72