HitPredict

Interactor 1: RAPH1 (Q70E73)
Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1)
Gene: RAPH1

Interactor 2: SH3G1 (Q99961)
Endophilin-A2 (EEN fusion partner of MLL) (Endophilin-2) (Extra eleven-nineteen leukemia fusion gene protein) (EEN) (SH3 domain protein 2B) (SH3 domain-containing GRB2-like protein 1)
Gene: SH3GL1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	25517094
Identification Methods	pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1250 Hs			1 368
+	Hs
		1173967 RAPH1_HUMAN (1-1250): 0: 627: 100.00		SH3G3_HUMAN (1-368): 1.31e-87: 270: 66.30
+	Hs
		1173966 RAPH1_HUMAN (1-1250): 0: 627: 100.00		SH3G2_HUMAN (1-368): 1.98e-84: 261: 68.75
+	Mm
		94694 F2Z3U3_MOUSE (1-1250): 0: 583: 89.65		SH3G3_MOUSE (1-367): 8.72e-87: 267: 63.76
+	Hs
		1191260 AB1IP_HUMAN (152-749): 2.63e-146: 459: 40.43		PACN1_HUMAN (16-363): 9.35e-37: 139: 14.89
+	Hs
		1191264 AB1IP_HUMAN (152-749): 2.63e-146: 459: 40.43		PACN2_HUMAN (16-364): 1.92e-34: 134: 14.97
+	Hs
		924543 GRB10_HUMAN (111-591): 4.23e-121: 389: 24.95		GRB2_HUMAN (311-367): 1.59e-11: 65.2: 41.38
+	Ce
		666202 MIG10_CAEEL (190-655): 8.61e-87: 301: 32.21		SEM5_CAEEL (312-360): 2.06e-11: 65.1: 55.10
+	Mm
		88460 D3Z656_MOUSE (503-893): 4.52e-10: 66.4: 12.59		SH3G3_MOUSE (1-367): 8.72e-87: 267: 63.76
+	Mm
		88459 D3Z656_MOUSE (503-893): 4.52e-10: 66.4: 12.59		SH3G2_MOUSE (1-368): 8.98e-84: 260: 69.02
+	Dm
		993213 Q9VWB7_DROME (252-913): 6.42e-71: 261: 23.05		GRAP_DROME (301-360): 1.2e-10: 62.4: 48.33
+	Hs
		1264828 TITIN_HUMAN (586-1241): 1.11e-11: 71.9: 13.92		SHLB1_HUMAN (10-363): 3.1e-69: 223: 25.28
+	Ce
		70017 G5EBN5_CAEEL (739-1246): 1.77e-10: 67.9: 10.24		SH3GH_CAEEL (1-366): 1.14e-70: 227: 44.76
+	Mm
		761854 ZO1_MOUSE (514-1213): 1.47e-26: 120: 12.73		SRC8_MOUSE (85-362): 7.3e-38: 144: 13.62
+	Hs
		554292 MUC1_HUMAN (540-1249): 7.9e-36: 150: 11.97		GRB2_HUMAN (311-367): 1.59e-11: 65.2: 41.38
+	Hs
		596232 TITIN_HUMAN (586-1241): 1.11e-11: 71.9: 13.92		NEBU_HUMAN (7-363): 5.75e-36: 141: 16.13
+	Hs
		924760 PRG4_HUMAN (510-1162): 1.96e-15: 84.1: 12.08		GRB2_HUMAN (311-367): 1.59e-11: 65.2: 41.38