Protein: SMCA1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1 (SMARCA1) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A1) (EC 3.6.4.-) (Global transcription activator SNF2L1) (Nucleosome-remodeling factor subunit SNF2L) (SNF2L) (SNF2 related chromatin remodeling ATPase 1)

Gene: SMCA1, SMARCA1
Organism: Homo sapiens
Interactions: 188
UniProt ID: P28370

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0003677 - DNA binding
GO:0003682 - chromatin binding
GO:0004386 - helicase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

703300

RBBP4
Histone-binding protein RBBP4

4

20

Small-scale

0.906

High

703326

RBBP7
Histone-binding protein RBBP7

4

20

Small-scale

0.903

High

703397

BAZ1B
Tyrosine-protein kinase BAZ1B

4

20

High-throughput

0.892

High

703289

H31
Histone H3.1

4

20

Small-scale

0.873

High

501917

H2AZ
Histone H2A.Z

2

20

High-throughput

0.789

High

703367

RSF1
Remodeling and spacing factor 1

2

20

Small-scale

0.789

High

243551

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

2

17

High-throughput

0.754

High

285095

EED
Polycomb protein EED

2

20

High-throughput

0.754

High

703303

CHD3
Chromodomain-helicase-DNA-binding protein 3

2

15

High-throughput

0.754

High

703315

CHD4
Chromodomain-helicase-DNA-binding protein 4

2

15

High-throughput

0.754

High

703301

BPTF
Nucleosome-remodeling factor subunit BPTF

4

20

Small-scale

0.699

High

502248

H2A1
Histone H2A type 1

1

20

High-throughput

0.691

High

703292

CBX1
Chromobox protein homolog 1

1

20

High-throughput

0.691

High

703328

H2B2E
Histone H2B type 2-E

1

20

High-throughput

0.691

High

703387

BAZ1A
Bromodomain adjacent to zinc finger domain protein 1A

1

20

High-throughput

0.691

High

703345

BAP18
BPTF-associated chromatin complex component 1

4

4

High-throughput

0.683

High

703379

DEFI6
Differentially expressed in FDCP 6 homolog

3

7

High-throughput

0.667

High

486987

PARP1
Poly [ADP-ribose] polymerase 1

3

20

Small-scale

0.656

High

703371

CECR2
Chromatin remodeling regulator CECR2

3

20

Small-scale

0.656

High

703325

EZH2
Histone-lysine N-methyltransferase EZH2

3

20

High-throughput

0.640

High

703385

DPOE3
DNA polymerase epsilon subunit 3

2

4

High-throughput

0.628

High

703372

DPY30
Protein dpy-30 homolog

2

2

Small-scale

0.618

High

277566

H2AY
Core histone macro-H2A.1

1

20

High-throughput

0.618

High

315162

RECQ4
ATP-dependent DNA helicase Q4

1

19

High-throughput

0.618

High

591490

H2AX
Histone H2AX

1

20

High-throughput

0.618

High

703282

CENPA
Histone H3-like centromeric protein A

1

20

High-throughput

0.618

High

703288

H2B1C
Histone H2B type 1-C/E/F/G/I

1

20

High-throughput

0.618

High

703290

RED1
Double-stranded RNA-specific editase 1

1

20

High-throughput

0.618

High

703293

H33
Histone H3.3

1

20

High-throughput

0.618

High

703296

ERCC6
DNA excision repair protein ERCC-6

1

19

Small-scale

0.618

High

703310

CBX3
Chromobox protein homolog 3

1

20

High-throughput

0.618

High

703318

SHPRH
E3 ubiquitin-protein ligase SHPRH

1

19

High-throughput

0.618

High

703356

NUP43
Nucleoporin Nup43

1

20

High-throughput

0.618

High

703359

FBXW7
F-box/WD repeat-containing protein 7

1

11

High-throughput

0.618

High

703360

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

15

High-throughput

0.618

High

703393

HMGX4
HMG domain-containing protein 4

2

20

High-throughput

0.611

High

648327

USF1
Upstream stimulatory factor 1

2

20

Small-scale

0.584

High

703346

DDX60
Probable ATP-dependent RNA helicase DDX60

1

19

High-throughput

0.575

High

557117

SRC
Proto-oncogene tyrosine-protein kinase Src

2

6

High-throughput

0.571

High

631076

RAB5A
Ras-related protein Rab-5A

2

4

High-throughput

0.571

High

345406

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

20

High-throughput

0.553

High

703338

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.553

High

74438

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

13

High-throughput

0.536

High

133085

FOXE1
Forkhead box protein E1

1

20

High-throughput

0.536

High

158402

RFXK
DNA-binding protein RFXANK

1

7

High-throughput

0.536

High

329426

EPN2
Epsin-2

1

3

High-throughput

0.536

High

348058

M4K4
Mitogen-activated protein kinase kinase kinase kinase 4

1

16

High-throughput

0.536

High

455703

H10
Histone H1.0

1

3

High-throughput

0.536

High

481110

HMGB1
High mobility group protein B1

1

20

High-throughput

0.536

High

541844

TOP1
DNA topoisomerase 1

1

7

High-throughput

0.536

High

593921

NCK1
SH2/SH3 adapter protein NCK1

1

9

High-throughput

0.536

High

601569

HMGA1
High mobility group protein HMG-I/HMG-Y

1

4

High-throughput

0.536

High

703277

RS19
Small ribosomal subunit protein eS19

1

7

High-throughput

0.536

High

703278

MAGA3
Melanoma-associated antigen 3

1

5

High-throughput

0.536

High

703284

IMA5
Importin subunit alpha-5

1

20

High-throughput

0.536

High

703286

FOXG1
Forkhead box protein G1

1

20

High-throughput

0.536

High

703287

MAX
Protein max

1

20

High-throughput

0.536

High

703291

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

1

3

High-throughput

0.536

High

703294

FOXK2
Forkhead box protein K2

1

20

High-throughput

0.536

High

703295

TIE2
Angiopoietin-1 receptor

1

4

High-throughput

0.536

High

703297

SUH
Recombining binding protein suppressor of hairless

1

11

High-throughput

0.536

High

703299

SSRP1
FACT complex subunit SSRP1

1

20

High-throughput

0.536

High

703304

FOXC1
Forkhead box protein C1

1

20

High-throughput

0.536

High

703305

FOXL1
Forkhead box protein L1

1

20

High-throughput

0.536

High

703306

MYO1E
Unconventional myosin-Ie

1

12

High-throughput

0.536

High

703307

PRDM2
PR domain zinc finger protein 2

1

6

High-throughput

0.536

High

703317

NUMA1
Nuclear mitotic apparatus protein 1

1

15

High-throughput

0.536

High

703323

TEBP
Prostaglandin E synthase 3

1

1

High-throughput

0.536

High

703324

TEAD2
Transcriptional enhancer factor TEF-4

1

7

High-throughput

0.536

High

703336

IFIX
Pyrin and HIN domain-containing protein 1

1

10

High-throughput

0.536

High

703340

POGZ
Pogo transposable element with ZNF domain

1

2

High-throughput

0.536

High

703349

RYBP
RING1 and YY1-binding protein

1

3

High-throughput

0.536

High

703354

NF2IP
NFATC2-interacting protein

1

1

High-throughput

0.536

High

703369

VRK1
Serine/threonine-protein kinase VRK1

1

6

High-throughput

0.536

High

703373

FOXQ1
Forkhead box protein Q1

1

20

High-throughput

0.536

High

703377

NUCKS
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

1

2

High-throughput

0.536

High

703386

CHRC1
Chromatin accessibility complex protein 1

1

3

High-throughput

0.536

High

703390

FOXJ2
Forkhead box protein J2

1

20

High-throughput

0.536

High

703330

INAVA
Innate immunity activator protein

1

0

High-throughput

0.513

High

703341

ZN467
Zinc finger protein 467

1

0

High-throughput

0.513

High

703322

EEA1
Early endosome antigen 1

1

19

High-throughput

0.489

High

703352

NECP1
Adaptin ear-binding coat-associated protein 1

1

1

High-throughput

0.489

High

703394

CTNA3
Catenin alpha-3

1

1

High-throughput

0.489

High

703398

KLH20
Kelch-like protein 20

1

2

High-throughput

0.489

High

66844

DUXA
Double homeobox protein A

1

19

High-throughput

0.479

High

131750

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

3

High-throughput

0.479

High

142851

NFIB
Nuclear factor 1 B-type

1

20

High-throughput

0.479

High

155289

CDKA1
Cyclin-dependent kinase 2-associated protein 1

1

9

High-throughput

0.479

High

156986

CTRO
Citron Rho-interacting kinase

1

9

High-throughput

0.479

High

168196

HAT1
Histone acetyltransferase type B catalytic subunit

1

2

High-throughput

0.479

High

175842

SET1A
Histone-lysine N-methyltransferase SETD1A

1

20

Small-scale

0.479

High

190826

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

10

High-throughput

0.479

High

210243

PHF1
PHD finger protein 1

1

9

High-throughput

0.479

High

222747

PRC1
Protein regulator of cytokinesis 1

1

4

High-throughput

0.479

High

247689

NUPR1
Nuclear protein 1

1

1

High-throughput

0.479

High

259489

BRD4
Bromodomain-containing protein 4

1

20

Small-scale

0.479

High

274283

SIN3B
Paired amphipathic helix protein Sin3b

1

17

High-throughput

0.479

High

282221

SAP30
Histone deacetylase complex subunit SAP30

1

5

High-throughput

0.479

High

316758

MTA2
Metastasis-associated protein MTA2

1

20

High-throughput

0.479

High

330682

KI20A
Kinesin-like protein KIF20A

1

19

High-throughput

0.479

High

352080

MBD3
Methyl-CpG-binding domain protein 3

1

20

High-throughput

0.479

High

371240

MYC
Myc proto-oncogene protein

1

20

High-throughput

0.479

High

400329

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

12

High-throughput

0.479

High

411412

NTRK1
High affinity nerve growth factor receptor

1

7

High-throughput

0.479

High

413247

P53
Cellular tumor antigen p53

1

8

High-throughput

0.479

High

442878

PRGR
Progesterone receptor

1

20

Small-scale

0.479

High

463355

LYN
Tyrosine-protein kinase Lyn

1

6

High-throughput

0.479

High

473807

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

519464

MYBB
Myb-related protein B

1

15

High-throughput

0.479

High

586533

RS2
Small ribosomal subunit protein uS5

1

5

High-throughput

0.479

High

587979

RFA2
Replication protein A 32 kDa subunit

1

7

High-throughput

0.479

High

643696

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

5

High-throughput

0.479

High

674083

BRD2
Bromodomain-containing protein 2

1

20

High-throughput

0.479

High

694689

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

11

High-throughput

0.479

High

697009

APEX1
DNA repair nuclease/redox regulator APEX1

1

3

High-throughput

0.479

High

702875

DPOD1
DNA polymerase delta catalytic subunit

1

3

High-throughput

0.479

High

703273

GRK5
G protein-coupled receptor kinase 5

1

2

High-throughput

0.479

High

703274

PHB1
Prohibitin 1

1

9

High-throughput

0.479

High

703275

VGFR2
Vascular endothelial growth factor receptor 2

1

7

High-throughput

0.479

High

703276

COIL
Coilin

1

7

High-throughput

0.479

High

703279

GATA4
Transcription factor GATA-4

1

20

High-throughput

0.479

High

703283

LHX2
LIM/homeobox protein Lhx2

1

11

High-throughput

0.479

High

703285

PLK1
Serine/threonine-protein kinase PLK1

1

11

High-throughput

0.479

High

703302

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

703308

CAF1A
Chromatin assembly factor 1 subunit A

1

18

High-throughput

0.479

High

703309

CAF1B
Chromatin assembly factor 1 subunit B

1

16

High-throughput

0.479

High

703311

TIF1B
Transcription intermediary factor 1-beta

1

16

High-throughput

0.479

High

703312

G3BP1
Ras GTPase-activating protein-binding protein 1

1

7

High-throughput

0.479

High

703313

MTA1
Metastasis-associated protein MTA1

1

20

High-throughput

0.479

High

703314

KLF9
Krueppel-like factor 9

1

16

High-throughput

0.479

High

703316

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.479

High

703319

SUZ12
Polycomb protein SUZ12

1

9

High-throughput

0.479

High

703320

KIF14
Kinesin-like protein KIF14

1

6

High-throughput

0.479

High

703321

BRD3
Bromodomain-containing protein 3

1

20

High-throughput

0.479

High

703327

IF16
Gamma-interferon-inducible protein 16

1

10

High-throughput

0.479

High

703331

ARI4B
AT-rich interactive domain-containing protein 4B

1

20

High-throughput

0.479

High

703332

LIN52
Protein lin-52 homolog

1

1

High-throughput

0.479

High

703334

BRM1L
Breast cancer metastasis-suppressor 1-like protein

1

9

High-throughput

0.479

High

703335

LIN9
Protein lin-9 homolog

1

4

High-throughput

0.479

High

703339

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

12

High-throughput

0.479

High

703342

SLN11
Schlafen family member 11

1

4

High-throughput

0.479

High

703344

P66A
Transcriptional repressor p66-alpha

1

13

High-throughput

0.479

High

703350

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

8

High-throughput

0.479

High

703351

CGAS
Cyclic GMP-AMP synthase

1

7

High-throughput

0.479

High

703353

HJURP
Holliday junction recognition protein

1

1

High-throughput

0.479

High

703355

ARI1B
AT-rich interactive domain-containing protein 1B

1

20

Small-scale

0.479

High

703357

GATD1
GATA zinc finger domain-containing protein 1

1

1

High-throughput

0.479

High

703358

P66B
Transcriptional repressor p66-beta

1

13

High-throughput

0.479

High

703361

LIN37
Protein lin-37 homolog

1

4

High-throughput

0.479

High

703362

DDRGK
DDRGK domain-containing protein 1

1

4

High-throughput

0.479

High

703363

Z512B
Zinc finger protein 512B

1

16

High-throughput

0.479

High

703364

PWP2A
PWWP domain-containing protein 2A

1

10

High-throughput

0.479

High

703366

SIN3A
Paired amphipathic helix protein Sin3a

1

17

High-throughput

0.479

High

703368

TBX5
T-box transcription factor TBX5

1

14

High-throughput

0.479

High

703370

MTA3
Metastasis-associated protein MTA3

1

20

High-throughput

0.479

High

703374

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

4

High-throughput

0.479

High

703375

SP130
Histone deacetylase complex subunit SAP130

1

11

High-throughput

0.479

High

703376

BC11A
BCL11 transcription factor A

1

11

High-throughput

0.479

High

703381

SDS3
Sin3 histone deacetylase corepressor complex component SDS3

1

9

High-throughput

0.479

High

703382

NANOG
Homeobox protein NANOG

1

20

High-throughput

0.479

High

703384

ANLN
Anillin

1

3

High-throughput

0.479

High

703388

RAD18
E3 ubiquitin-protein ligase RAD18

1

4

High-throughput

0.479

High

703389

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

5

High-throughput

0.479

High

703391

MBD2
Methyl-CpG-binding domain protein 2

1

20

High-throughput

0.479

High

703392

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

703395

XPO7
Exportin-7

1

1

High-throughput

0.479

High

703399

ZN330
Zinc finger protein 330

1

5

High-throughput

0.479

High

703400

MTF2
Metal-response element-binding transcription factor 2

1

9

High-throughput

0.479

High

703281

EFTU
Elongation factor Tu, mitochondrial

1

6

High-throughput

0.470

High

703378

TXNIP
Thioredoxin-interacting protein

1

5

High-throughput

0.470

High

319432

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

703298

FMR1
Fragile X messenger ribonucleoprotein 1

1

15

High-throughput

0.457

High

143397

E2F3
Transcription factor E2F3

1

5

Small-scale

0.445

High

429357

JUN
Transcription factor Jun

1

17

High-throughput

0.445

High

703280

RS10
Small ribosomal subunit protein eS10

1

7

High-throughput

0.445

High

703347

CA174
UPF0688 protein C1orf174

1

1

High-throughput

0.445

High

703383

TF7L2
Transcription factor 7-like 2

1

20

High-throughput

0.445

High

703396

BAZ2B
Bromodomain adjacent to zinc finger domain protein 2B

1

20

Small-scale

0.445

High

703329

CL16A
Protein CLEC16A

1

2

High-throughput

0.437

High

703333

TM128
Transmembrane protein 128

1

1

High-throughput

0.437

High

703343

DZIP3
E3 ubiquitin-protein ligase DZIP3

1

7

Small-scale

0.437

High

703348

RHG24
Rho GTPase-activating protein 24

1

6

High-throughput

0.437

High

703380

PKHA4
Pleckstrin homology domain-containing family A member 4

1

17

High-throughput

0.437

High

58792

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

3

High-throughput

0.407

High

85143

B7Z3K1
cDNA FLJ51973

1

1

High-throughput

0.407

High

391189

FRIL
Ferritin light chain

1

0

High-throughput

0.279

Low

703337

I23O2
Indoleamine 2,3-dioxygenase 2

1

0

High-throughput

0.279

Low

703365

BROMI
Protein broad-minded

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025