HitPredict

Interactor 1: MD13L (Q71F56)
Mediator of RNA polymerase II transcription subunit 13-like (Mediator complex subunit 13-like) (Thyroid hormone receptor-associated protein 2) (Thyroid hormone receptor-associated protein complex 240 kDa component-like)
Gene: MED13L

Interactor 2: MED12 (Q93074)
Mediator of RNA polymerase II transcription subunit 12 (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (Mediator complex subunit 12) (OPA-containing protein) (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Trinucleotide repeat-containing gene 11 protein)
Gene: MED12

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.694

Property	Details
Experiments	26496610, 27684187, 24981860, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003712 - transcription coregulator activity GO:0005654 - nucleoplasm GO:0016592 - mediator complex
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 2210 Hs			1 2177
+	Hs
		1174756 MD13L_HUMAN (1-2210): 0: 3763: 100.00		MD12L_HUMAN (1-2175): 0: 2159: 56.63
+	Hs
		1274360 MED13_HUMAN (4-2210): 0: 3181: 51.34		MED12_HUMAN (1-2177): 0: 2488: 100.00
+	Hs
		1206166 MED13_HUMAN (4-2210): 0: 3181: 51.34		MD12L_HUMAN (1-2175): 0: 2159: 56.63
+	Dm
		1182310 MED13_DROME (943-1152): 8.63e-10: 66.7: 23.77		MED12_DROME (10-206): 7.4e-71: 267: 52.53