Protein: EPB41
Protein 4.1 (P4.1) (4.1R) (Band 4.1) (EPB4.1) (Erythrocyte membrane protein band 4.1)

Gene: EPB41
Organism: Homo sapiens
Interactions: 215
UniProt ID: P11171

Gene Ontology (top 5):
GO:0003779 - actin binding
GO:0005200 - structural constituent of cytoskeleton
GO:0005516 - calmodulin binding
GO:0005545 - 1-phosphatidylinositol binding
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

374363

RASH
GTPase HRas

2

20

High-throughput

0.754

High

375123

RASK
GTPase KRas

2

20

High-throughput

0.754

High

538934

1433G
14-3-3 protein gamma

5

20

High-throughput

0.718

High

539010

E41L1
Band 4.1-like protein 1

1

15

High-throughput

0.691

High

539024

E41L3
Band 4.1-like protein 3

1

17

High-throughput

0.691

High

538960

NUMA1
Nuclear mitotic apparatus protein 1

2

13

Small-scale

0.644

High

538914

ICLN
Methylosome subunit pICln

2

7

High-throughput

0.631

High

134431

EF2K
Eukaryotic elongation factor 2 kinase

2

3

High-throughput

0.628

High

126447

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

373746

RASN
GTPase NRas

1

20

High-throughput

0.618

High

411254

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.618

High

463297

LYN
Tyrosine-protein kinase Lyn

1

20

High-throughput

0.618

High

538856

EPB41
Protein 4.1

1

16

Small-scale

0.618

High

538866

EZRI
Ezrin

1

17

High-throughput

0.618

High

538887

UFO
Tyrosine-protein kinase receptor UFO

1

20

Small-scale

0.618

High

538911

RAB5C
Ras-related protein Rab-5C

1

5

High-throughput

0.618

High

538920

RAB25
Ras-related protein Rab-25

1

4

High-throughput

0.618

High

538923

RAB8A
Ras-related protein Rab-8A

1

5

High-throughput

0.618

High

538924

RAB2A
Ras-related protein Rab-2A

1

8

High-throughput

0.618

High

538925

RAB10
Ras-related protein Rab-10

1

5

High-throughput

0.618

High

538937

RB11A
Ras-related protein Rab-11A

1

4

High-throughput

0.618

High

538945

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.618

High

538962

RAB35
Ras-related protein Rab-35

1

12

High-throughput

0.618

High

538968

RB11B
Ras-related protein Rab-11B

1

8

High-throughput

0.618

High

539013

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

539020

ALK
ALK tyrosine kinase receptor

1

20

High-throughput

0.618

High

295080

EIF3G
Eukaryotic translation initiation factor 3 subunit G

1

1

Small-scale

0.586

High

538903

YAP1
Transcriptional coactivator YAP1

2

20

Small-scale

0.584

High

538936

ARF6
ADP-ribosylation factor 6

2

6

High-throughput

0.584

High

538872

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

2

0

High-throughput

0.576

High

538874

FGFR3
Fibroblast growth factor receptor 3

1

20

High-throughput

0.575

High

539014

CPAP
Centrosomal P4.1-associated protein

1

6

Small-scale

0.573

High

395386

ESR1
Estrogen receptor

2

16

High-throughput

0.571

High

528945

TAU
Microtubule-associated protein tau

2

16

High-throughput

0.571

High

538880

1433T
14-3-3 protein theta

2

20

High-throughput

0.571

High

538951

1433F
14-3-3 protein eta

1

20

High-throughput

0.554

High

539017

ZO2
Tight junction protein 2

1

20

Small-scale

0.552

High

168620

CSKP
Peripheral plasma membrane protein CASK

1

20

Small-scale

0.536

High

354887

CHK2
Serine/threonine-protein kinase Chk2

1

5

High-throughput

0.536

High

388956

FINC
Fibronectin

1

3

High-throughput

0.536

High

538935

1433E
14-3-3 protein epsilon

1

6

High-throughput

0.536

High

538963

RNPS1
RNA-binding protein with serine-rich domain 1

1

9

High-throughput

0.536

High

538985

KIBRA
Protein KIBRA

1

18

High-throughput

0.536

High

538998

OPTN
Optineurin

1

18

High-throughput

0.536

High

538993

ZCH10
Zinc finger CCHC domain-containing protein 10

1

8

High-throughput

0.523

High

538877

CDK2
Cyclin-dependent kinase 2

1

2

High-throughput

0.515

High

538879

SYVC
Valine--tRNA ligase

1

2

High-throughput

0.515

High

538881

CALR
Calreticulin

1

1

High-throughput

0.515

High

538891

MYH9
Myosin-9

1

4

High-throughput

0.515

High

538893

TAGL2
Transgelin-2

1

5

High-throughput

0.515

High

538904

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

6

Small-scale

0.515

High

421388

A4
Amyloid-beta precursor protein

1

7

High-throughput

0.515

High

538992

NECP1
Adaptin ear-binding coat-associated protein 1

1

0

High-throughput

0.513

High

539025

C2CD2
C2 domain-containing protein 2

1

0

High-throughput

0.513

High

538857

SPTB1
Spectrin beta chain, erythrocytic

1

20

Small-scale

0.501

High

538913

IMA1
Importin subunit alpha-1

1

2

Small-scale

0.501

High

538953

DLG1
Disks large homolog 1

1

20

Small-scale

0.501

High

538957

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

20

Small-scale

0.501

High

176643

PUR4
Phosphoribosylformylglycinamidine synthase

1

0

High-throughput

0.493

High

538987

KT222
Keratin-like protein KRT222

1

7

High-throughput

0.489

High

539009

KDM4C
Lysine-specific demethylase 4C

1

2

High-throughput

0.489

High

539021

WDR3
WD repeat-containing protein 3

1

2

High-throughput

0.489

High

376969

ANF
Natriuretic peptides A

1

0

Small-scale

0.480

High

131115

CLIC1
Chloride intracellular channel protein 1

1

2

High-throughput

0.479

High

165246

PSA7
Proteasome subunit alpha type-7

1

2

High-throughput

0.479

High

210522

DC1L2
Cytoplasmic dynein 1 light intermediate chain 2

1

1

High-throughput

0.479

High

217760

TGON2
Trans-Golgi network integral membrane protein 2

1

5

High-throughput

0.479

High

225920

STX6
Syntaxin-6

1

2

High-throughput

0.479

High

240585

PRKN
E3 ubiquitin-protein ligase parkin

1

6

High-throughput

0.479

High

247220

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

10

High-throughput

0.479

High

249557

SNX3
Sorting nexin-3

1

2

High-throughput

0.479

High

289417

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

1

2

High-throughput

0.479

High

291195

NU155
Nuclear pore complex protein Nup155

1

1

High-throughput

0.479

High

299043

FLOT1
Flotillin-1

1

9

High-throughput

0.479

High

319340

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.479

High

361995

AATM
Aspartate aminotransferase, mitochondrial

1

1

High-throughput

0.479

High

367563

CAH2
Carbonic anhydrase 2

1

2

High-throughput

0.479

High

413075

P53
Cellular tumor antigen p53

1

6

High-throughput

0.479

High

420059

GLPC
Glycophorin-C

1

8

Small-scale

0.479

High

464102

TPM2
Tropomyosin beta chain

1

1

High-throughput

0.479

High

536374

HSP7C
Heat shock cognate 71 kDa protein

1

4

High-throughput

0.479

High

538858

LAMP1
Lysosome-associated membrane glycoprotein 1

1

8

High-throughput

0.479

High

538861

CADH1
Cadherin-1

1

14

High-throughput

0.479

High

538862

MYH1
Myosin-1

1

4

High-throughput

0.479

High

538863

TCTP
Translationally-controlled tumor protein

1

2

High-throughput

0.479

High

538868

PSB1
Proteasome subunit beta type-1

1

4

High-throughput

0.479

High

538869

FLNA
Filamin-A

1

8

High-throughput

0.479

High

538870

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

7

High-throughput

0.479

High

538871

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

1

1

High-throughput

0.479

High

538873

SCP2
Sterol carrier protein 2

1

1

High-throughput

0.479

High

538878

PSA1
Proteasome subunit alpha type-1

1

2

High-throughput

0.479

High

538882

PSB5
Proteasome subunit beta type-5

1

1

High-throughput

0.479

High

538884

MARCS
Myristoylated alanine-rich C-kinase substrate

1

11

High-throughput

0.479

High

538888

STIP1
Stress-induced-phosphoprotein 1

1

4

High-throughput

0.479

High

538890

PROF2
Profilin-2

1

1

High-throughput

0.479

High

538892

MYH10
Myosin-10

1

4

High-throughput

0.479

High

538895

CCNF
Cyclin-F

1

5

High-throughput

0.479

High

538897

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

2

High-throughput

0.479

High

538898

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

20

High-throughput

0.479

High

538900

MUC18
Cell surface glycoprotein MUC18

1

15

High-throughput

0.479

High

538905

ATPO
ATP synthase peripheral stalk subunit OSCP, mitochondrial

1

1

High-throughput

0.479

High

538906

GRIA4
Glutamate receptor 4

1

12

Small-scale

0.479

High

538908

SRP09
Signal recognition particle 9 kDa protein

1

2

High-throughput

0.479

High

538909

PSB3
Proteasome subunit beta type-3

1

2

High-throughput

0.479

High

538910

TCPQ
T-complex protein 1 subunit theta

1

5

High-throughput

0.479

High

538916

NH2L1
NHP2-like protein 1

1

2

High-throughput

0.479

High

538921

MTPN
Myotrophin

1

17

High-throughput

0.479

High

538922

PSA6
Proteasome subunit alpha type-6

1

2

High-throughput

0.479

High

538926

UBC12
NEDD8-conjugating enzyme Ubc12

1

1

High-throughput

0.479

High

538927

ABCE1
ATP-binding cassette sub-family E member 1

1

4

High-throughput

0.479

High

538928

RS3A
Small ribosomal subunit protein eS1

1

1

High-throughput

0.479

High

538929

PSME3
Proteasome activator complex subunit 3

1

1

High-throughput

0.479

High

538933

COPZ1
Coatomer subunit zeta-1

1

3

High-throughput

0.479

High

538938

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

3

High-throughput

0.479

High

538939

FKB1A
Peptidyl-prolyl cis-trans isomerase FKBP1A

1

1

High-throughput

0.479

High

538940

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.479

High

538941

DYL1
Dynein light chain 1, cytoplasmic

1

2

High-throughput

0.479

High

538943

UB2L3
Ubiquitin-conjugating enzyme E2 L3

1

1

High-throughput

0.479

High

538947

FABP5
Fatty acid-binding protein 5

1

1

High-throughput

0.479

High

538948

CAV1
Caveolin-1

1

5

High-throughput

0.479

High

538949

TF65
Transcription factor p65

1

7

High-throughput

0.479

High

538950

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

1

3

High-throughput

0.479

High

538952

DHX9
ATP-dependent RNA helicase A

1

3

High-throughput

0.479

High

538954

UB2V1
Ubiquitin-conjugating enzyme E2 variant 1

1

1

High-throughput

0.479

High

538955

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

1

High-throughput

0.479

High

538956

FHL1
Four and a half LIM domains protein 1

1

9

High-throughput

0.479

High

538958

DCTN1
Dynactin subunit 1

1

7

Small-scale

0.479

High

538961

TNIP1
TNFAIP3-interacting protein 1

1

20

High-throughput

0.479

High

538965

TSN
Translin

1

2

High-throughput

0.479

High

538967

MARE1
Microtubule-associated protein RP/EB family member 1

1

2

High-throughput

0.479

High

538970

OCLN
Occludin

1

10

High-throughput

0.479

High

538972

MIDN
Midnolin

1

4

High-throughput

0.479

High

538979

RICTR
Rapamycin-insensitive companion of mTOR

1

5

High-throughput

0.479

High

538980

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.479

High

538984

NAA40
N-alpha-acetyltransferase 40

1

3

High-throughput

0.479

High

538986

SMC5
Structural maintenance of chromosomes protein 5

1

3

High-throughput

0.479

High

538989

ARL14
ADP-ribosylation factor-like protein 14

1

13

High-throughput

0.479

High

538991

SERB1
SERPINE1 mRNA-binding protein 1

1

4

High-throughput

0.479

High

538994

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

5

High-throughput

0.479

High

538999

FMNL2
Formin-like protein 2

1

5

High-throughput

0.479

High

539000

CIC
Protein capicua homolog

1

19

High-throughput

0.479

High

539001

PSB7
Proteasome subunit beta type-7

1

2

High-throughput

0.479

High

539003

PHB2
Prohibitin-2

1

2

High-throughput

0.479

High

539008

WWTR1
WW domain-containing transcription regulator protein 1

1

20

High-throughput

0.479

High

539011

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.479

High

539012

CYBP
Calcyclin-binding protein

1

2

High-throughput

0.479

High

539018

ZRAN1
Ubiquitin thioesterase ZRANB1

1

9

High-throughput

0.479

High

539019

TR112
Multifunctional methyltransferase subunit TRM112-like protein

1

1

High-throughput

0.479

High

538885

ECHM
Enoyl-CoA hydratase, mitochondrial

1

3

High-throughput

0.470

High

539006

NSD3
Histone-lysine N-methyltransferase NSD3

1

1

High-throughput

0.470

High

361769

PNPH
Purine nucleoside phosphorylase

1

0

High-throughput

0.458

High

361843

HPRT
Hypoxanthine-guanine phosphoribosyltransferase

1

0

High-throughput

0.458

High

402745

CYTB
Cystatin-B

1

0

High-throughput

0.458

High

528171

THIO
Thioredoxin

1

0

High-throughput

0.458

High

538859

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.458

High

538864

MIF
Macrophage migration inhibitory factor

1

0

High-throughput

0.458

High

538867

CBR1
Carbonyl reductase [NADPH] 1

1

0

High-throughput

0.458

High

538875

EF1B
Elongation factor 1-beta

1

0

High-throughput

0.458

High

538876

PPAC
Low molecular weight phosphotyrosine protein phosphatase

1

0

High-throughput

0.458

High

538883

TMOD1
Tropomodulin-1

1

0

High-throughput

0.458

High

538886

PEBP1
Phosphatidylethanolamine-binding protein 1

1

0

High-throughput

0.458

High

538901

RANG
Ran-specific GTPase-activating protein

1

0

High-throughput

0.458

High

538902

PRS6B
26S proteasome regulatory subunit 6B

1

0

High-throughput

0.458

High

538912

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

0

High-throughput

0.458

High

538930

PHS
Pterin-4-alpha-carbinolamine dehydratase

1

0

High-throughput

0.458

High

538942

RL38
Large ribosomal subunit protein eL38

1

0

High-throughput

0.458

High

538944

PA1B2
Platelet-activating factor acetylhydrolase IB subunit alpha2

1

0

High-throughput

0.458

High

538946

CYC
Cytochrome c

1

0

High-throughput

0.458

High

538959

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

0

Small-scale

0.458

High

538964

ELOC
Elongin-C

1

0

High-throughput

0.458

High

538973

Q53Y06
ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E isoform 1

1

0

High-throughput

0.458

High

538977

Q6FGG2
VAMP3 protein

1

0

High-throughput

0.458

High

538978

Q6FGH5
Small ribosomal subunit protein eS21

1

0

High-throughput

0.458

High

539005

TXD17
Thioredoxin domain-containing protein 17

1

0

High-throughput

0.458

High

539023

HIG1A
HIG1 domain family member 1A, mitochondrial

1

0

High-throughput

0.458

High

538865

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

7

High-throughput

0.445

High

538899

HD
Huntingtin

1

5

High-throughput

0.445

High

538917

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

14

High-throughput

0.445

High

538969

NF2L2
Nuclear factor erythroid 2-related factor 2

1

3

High-throughput

0.445

High

538974

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

5

High-throughput

0.445

High

538988

LAT4
Large neutral amino acids transporter small subunit 4

1

5

High-throughput

0.445

High

538990

CTL3
Choline transporter-like protein 3

1

4

High-throughput

0.445

High

259353

BRD4
Bromodomain-containing protein 4

1

6

High-throughput

0.437

High

538889

S10AB
Protein S100-A11

1

6

High-throughput

0.437

High

538894

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

2

High-throughput

0.437

High

538907

EFTU
Elongation factor Tu, mitochondrial

1

1

High-throughput

0.437

High

538966

SF01
Splicing factor 1

1

4

High-throughput

0.437

High

538975

Q5SQT9
small monomeric GTPase

1

20

High-throughput

0.437

High

538976

DCA15
DDB1- and CUL4-associated factor 15

1

1

High-throughput

0.437

High

538983

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.437

High

538995

ESR2
Estrogen receptor beta

1

16

High-throughput

0.437

High

538996

CK052
Uncharacterized protein C11orf52

1

8

High-throughput

0.437

High

538997

LRC59
Leucine-rich repeat-containing protein 59

1

5

High-throughput

0.437

High

539002

SEC62
Translocation protein SEC62

1

2

High-throughput

0.437

High

539007

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

1

High-throughput

0.437

High

539016

MED4
Mediator of RNA polymerase II transcription subunit 4

1

1

High-throughput

0.437

High

539022

PIN4
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4

1

1

High-throughput

0.437

High

539026

TIM13
Mitochondrial import inner membrane translocase subunit Tim13

1

1

High-throughput

0.437

High

350274

DDAH2
Putative hydrolase DDAH2

1

4

High-throughput

0.407

High

538981

NEK10
Serine/threonine-protein kinase Nek10

1

10

High-throughput

0.407

High

538982

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

4

High-throughput

0.407

High

538918

RWD2B
RWD domain-containing protein 2B

1

0

High-throughput

0.299

High

538971

CP100
Cilia- and flagella-associated protein 100

1

0

High-throughput

0.268

Low

293113

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

299604

ATP5L
ATP synthase F(0) complex subunit g, mitochondrial

1

0

High-throughput

0.249

Low

528408

COX5B
Cytochrome c oxidase subunit 5B, mitochondrial

1

0

High-throughput

0.249

Low

538860

KCRU
Creatine kinase U-type, mitochondrial

1

0

High-throughput

0.249

Low

538896

EIF1
Eukaryotic translation initiation factor 1

1

0

High-throughput

0.249

Low

538915

KAD2
Adenylate kinase 2, mitochondrial

1

0

High-throughput

0.249

Low

538919

TMM33
Transmembrane protein 33

1

0

High-throughput

0.249

Low

538931

CH10
10 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.249

Low

538932

DAD1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1

1

0

High-throughput

0.249

Low

539004

RT63
Large ribosomal subunit protein mL63

1

0

High-throughput

0.249

Low

539015

DLRB1
Dynein light chain roadblock-type 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025