HitPredict

Interactor 1: CIAO1 (Q7K1Y4)
Probable cytosolic iron-sulfur protein assembly protein Ciao1
Gene: CIAO1

Interactor 2: GALL2 (Q9VTC4)
MIP18 family protein galla-2
Gene: galla-2

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.919

Property	Details
Experiments	32404863, 32632277, 14605208, 22036573, 19079254
Identification Methods	affinity chromatography technology, x-ray crystallography, two hybrid, two hybrid array
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	FeS_assembly_P~WD40
Common GO terms	GO:0016226 - iron-sulfur cluster assembly GO:0097361 - cytosolic [4Fe-4S] assembly targeting complex
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 335 Dm			1 156
+	Dm
		1179144 CIAO1_DROME (1-335): 2.73e-100: 300: 100.00		GALL1_DROME (36-155): 1.54e-59: 185: 49.19
+	Sc
		755929 CIAO1_YEAST (1-335): 7.51e-74: 232: 35.07		YHS2_YEAST (16-152): 6.26e-57: 179: 52.32
+	Hs
		283065 CIAO1_HUMAN (180-335): 9.8e-25: 104: 23.57		CIA2B_HUMAN (5-155): 8.5e-78: 229: 71.52
+	Hs
		793045 LIS1_HUMAN (222-333): 6.02e-16: 80.1: 16.07		CIA2B_HUMAN (5-155): 8.5e-78: 229: 71.52
+	Ce
		248062 CIAO1_CAEEL (194-335): 4.33e-16: 79.6: 21.13		U195_CAEEL (5-152): 1.1e-72: 216: 59.60
+	Hs
		283023 CIAO1_HUMAN (180-335): 9.8e-25: 104: 23.57		CIA2A_HUMAN (36-152): 1.9e-58: 180: 54.17
+	Hs
		793031 LIS1_HUMAN (222-333): 6.02e-16: 80.1: 16.07		CIA2A_HUMAN (36-152): 1.9e-58: 180: 54.17
+	Sc
		630861 NLE1_YEAST (224-332): 5.33e-15: 77.4: 15.46		YHS2_YEAST (16-152): 6.26e-57: 179: 52.32