Protein: KNG1
Kininogen-1 (Alpha-2-thiol proteinase inhibitor) (Fitzgerald factor) (High molecular weight kininogen) (HMWK) (Williams-Fitzgerald-Flaujeac factor) [Cleaved into: Kininogen-1 heavy chain; T-kinin (Ile-Ser-Bradykinin); Bradykinin (Kallidin I); Lysyl-bradykinin (Kallidin II); Kininogen-1 light chain; Low molecular weight growth-promoting factor]

Gene: KNG1
Organism: Homo sapiens
Interactions: 55
UniProt ID: P01042

Gene Ontology (top 5):
GO:0004869 - cysteine-type endopeptidase inhibitor activity
GO:0005102 - signaling receptor binding
GO:0005179 - hormone activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

261581

CATL2
Cathepsin L2

4

13

High-throughput

0.892

High

370404

CATO
Cathepsin O

3

15

High-throughput

0.861

High

370388

KLKB1
Plasma kallikrein

5

1

Small-scale

0.712

High

370396

CATL1
Procathepsin L

1

13

High-throughput

0.691

High

370398

CATH
Pro-cathepsin H [Cleaved into: Cathepsin H mini chain; Cathepsin H

1

13

High-throughput

0.691

High

370395

CAN1
Calpain-1 catalytic subunit

4

2

High-throughput

0.691

High

370413

TECT1
Tectonic-1

3

1

High-throughput

0.667

High

370412

MEP1A
Meprin A subunit alpha

1

2

Small-scale

0.647

High

370402

VHL
von Hippel-Lindau disease tumor suppressor

3

0

High-throughput

0.638

High

370417

ZN562
Zinc finger protein 562

3

0

High-throughput

0.638

High

370415

TBB8
Tubulin beta-8 chain

2

7

High-throughput

0.611

High

370419

P3H3
Prolyl 3-hydroxylase 3

3

5

High-throughput

0.609

High

370421

GDPD1
Lysophospholipase D GDPD1

3

1

High-throughput

0.609

High

370424

SNX27
Sorting nexin-27

2

3

High-throughput

0.574

High

370426

ACE2
Angiotensin-converting enzyme 2

2

1

Small-scale

0.552

High

370411

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

Small-scale

0.537

High

210643

KLK10
Kallikrein-10

1

5

High-throughput

0.536

High

370401

CCR1
C-C chemokine receptor type 1

1

5

High-throughput

0.536

High

370430

PHF11
PHD finger protein 11

1

6

High-throughput

0.536

High

370406

STX17
Syntaxin-17

1

0

High-throughput

0.513

High

366303

PLMN
Plasminogen

1

1

Small-scale

0.501

High

370386

FRIL
Ferritin light chain

1

3

Small-scale

0.501

High

370387

FA11
Coagulation factor XI

1

2

Small-scale

0.501

High

370393

ITB2
Integrin beta-2

1

3

Small-scale

0.501

High

370394

KLK1
Kallikrein-1

1

6

Small-scale

0.501

High

370397

ELNE
Neutrophil elastase

1

5

Small-scale

0.501

High

370403

ECE1
Endothelin-converting enzyme 1

1

3

Small-scale

0.501

High

370410

UPAR
Urokinase plasminogen activator surface receptor

1

2

Small-scale

0.501

High

370428

C1QR1
Complement component C1q receptor

1

9

Small-scale

0.501

High

370416

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

2

High-throughput

0.489

High

370422

RHBL4
Rhomboid-related protein 4

1

3

High-throughput

0.489

High

370425

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

2

High-throughput

0.489

High

370429

MRC2
C-type mannose receptor 2

1

6

High-throughput

0.489

High

370432

2ABG
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform

1

1

High-throughput

0.489

High

370389

VTNC
Vitronectin

1

0

Small-scale

0.480

High

370390

K2C1
Keratin, type II cytoskeletal 1

1

0

Small-scale

0.480

High

369231

ANT3
Antithrombin-III

1

1

High-throughput

0.479

High

370391

DPB1
HLA class II histocompatibility antigen, DP beta 1 chain

1

2

High-throughput

0.479

High

370392

CPNS1
Calpain small subunit 1

1

1

High-throughput

0.479

High

370400

BKRB2
B2 bradykinin receptor

1

4

Small-scale

0.479

High

370405

BKRB1
B1 bradykinin receptor

1

4

Small-scale

0.479

High

370409

CO7A1
Collagen alpha-1(VII) chain

1

5

High-throughput

0.479

High

370408

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

0

High-throughput

0.458

High

261044

NSMA
Sphingomyelin phosphodiesterase 2

1

1

High-throughput

0.445

High

370385

FINC
Fibronectin

1

5

High-throughput

0.445

High

370399

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.445

High

370420

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

2

Small-scale

0.445

High

277226

PITX3
Pituitary homeobox 3

1

2

Small-scale

0.437

High

370423

SC65
Endoplasmic reticulum protein SC65

1

5

High-throughput

0.437

High

370414

AR13B
ADP-ribosylation factor-like protein 13B

1

1

High-throughput

0.407

High

370427

APC1
Anaphase-promoting complex subunit 1

4

0

High-throughput

0.360

High

370431

APC5
Anaphase-promoting complex subunit 5

3

0

High-throughput

0.347

High

370407

MLF1
Myeloid leukemia factor 1

1

0

High-throughput

0.279

Low

370418

CSN6
COP9 signalosome complex subunit 6

1

0

High-throughput

0.279

Low

370384

CRYAA
Alpha-crystallin A chain

1

0

High-throughput

0.261

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025