HitPredict

Interactor 1: Q7KA43 (Q7KA43)
Anaphase-promoting complex subunit 11
Gene: lmgA

Interactor 2: Q9W1E5 (Q9W1E5)
Anaphase-promoting complex subunit 2
Gene: mr

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.878

Property	Details
Experiments	22417125, 22491092, 37061542, unassigned1513
Identification Methods	two hybrid, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	ANAPC2~zf-ANAPC11, Cullin~zf-ANAPC11
Common GO terms	GO:0000151 - ubiquitin ligase complex GO:0005680 - anaphase-promoting complex GO:0031145 - anaphase-promoting complex-dependent catabolic process GO:0051301 - cell division
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 85 Dm			1 802
+	Hs
		921251 RBX1_HUMAN (2-82): 4.29e-28: 99: 36.05		CUL1_HUMAN (110-794): 0: 591: 13.04
+	Mm
		921509 RBX1_MOUSE (2-82): 4.29e-28: 99: 36.05		CUL1_MOUSE (110-794): 0: 591: 13.04
+	Dm
		1097212 RBX1A_DROME (2-82): 9.32e-28: 98.3: 36.05		CUL1_DROME (111-794): 0: 560: 13.64
+	Hs
		1348495 APC11_HUMAN (1-82): 1.6e-28: 99.4: 73.17		ANC2_HUMAN (58-802): 0: 558: 36.72
+	Hs
		921254 RBX1_HUMAN (2-82): 4.29e-28: 99: 36.05		CUL4A_HUMAN (123-790): 0: 549: 13.38
+	Mm
		921499 RBX1_MOUSE (2-82): 4.29e-28: 99: 36.05		CUL4A_MOUSE (123-790): 0: 544: 13.10
+	Hs
		921252 RBX1_HUMAN (2-82): 4.29e-28: 99: 36.05		CUL2_HUMAN (121-784): 0: 539: 10.63
+	Dm
		1124381 RBX1A_DROME (2-82): 9.32e-28: 98.3: 36.05		Q5BI50_DROME (99-790): 1.35e-179: 537: 13.30
+	Hs
		921253 RBX1_HUMAN (2-82): 4.29e-28: 99: 36.05		CUL3_HUMAN (103-791): 5.42e-179: 534: 12.04
+	Hs
		921255 RBX1_HUMAN (2-82): 4.29e-28: 99: 36.05		CUL4B_HUMAN (123-790): 6.41e-176: 531: 12.24
+	Mm
		56790 RBX1_MOUSE (2-82): 4.29e-28: 99: 36.05		CUL4B_MOUSE (123-790): 4.95e-175: 530: 12.10
+	At
		1210831 APC11_ARATH (1-82): 1.47e-30: 104: 60.98		APC2_ARATH (58-802): 2.59e-171: 518: 28.73
+	Dm
		1213855 RBX1A_DROME (2-82): 9.32e-28: 98.3: 36.05		Q8IP45_DROME (104-791): 1.06e-171: 521: 13.39
+	Sp
		142904 RBX1_SCHPO (2-82): 5.85e-28: 98.6: 38.37		CUL1_SCHPO (117-789): 6.8e-167: 503: 13.53
+	Dm
		1360503 RBX1A_DROME (2-82): 9.32e-28: 98.3: 36.05		Q9V9R2_DROME (121-790): 2.34e-164: 496: 10.47
+	Ce
		1088871 RBX1_CAEEL (2-82): 1.34e-27: 97.9: 36.05		CUL2_CAEEL (108-793): 1.27e-158: 482: 9.22
+	Hs
		1274066 APC11_HUMAN (1-82): 1.6e-28: 99.4: 73.17		CUL5_HUMAN (113-788): 1.39e-152: 466: 11.92
+	Hs
		921374 RBX1_HUMAN (2-82): 4.29e-28: 99: 36.05		CUL5_HUMAN (113-788): 1.39e-152: 466: 11.92
+	Sc
		1015167 APC11_YEAST (1-82): 2.72e-30: 106: 40.00		APC2_YEAST (240-802): 7.9e-114: 367: 20.37
+	Sp
		143631 RBX1_SCHPO (2-82): 5.85e-28: 98.6: 38.37		CUL3_SCHPO (490-694): 3.49e-37: 151: 21.50