Protein: LZTS1
Leucine zipper putative tumor suppressor 1 (F37/esophageal cancer-related gene-coding leucine-zipper motif) (Fez1)

Gene: LZTS1
Organism: Homo sapiens
Interactions: 123
UniProt ID: Q9Y250

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005886 - plasma membrane
GO:0014069 - postsynaptic density
GO:0016242 - negative regulation of macroautophagy
GO:0043197 - dendritic spine

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1411385

LZTS2
Leucine zipper putative tumor suppressor 2

6

19

High-throughput

0.732

High

1116147

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

2

20

High-throughput

0.611

High

132529

CDC7
Cell division cycle 7-related protein kinase

2

20

High-throughput

0.606

High

155815

TXND9
Thioredoxin domain-containing protein 9

2

2

High-throughput

0.606

High

180438

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

2

1

High-throughput

0.606

High

225730

AAKB2
5'-AMP-activated protein kinase subunit beta-2

2

6

High-throughput

0.606

High

681082

PSA1
Proteasome subunit alpha type-1

2

5

High-throughput

0.606

High

684439

DDX6
Probable ATP-dependent RNA helicase DDX6

2

6

High-throughput

0.606

High

821223

TXLNA
Alpha-taxilin

2

20

High-throughput

0.606

High

853871

MK09
Mitogen-activated protein kinase 9

2

9

High-throughput

0.606

High

868282

SYQ
Glutamine--tRNA ligase

2

2

High-throughput

0.606

High

921835

COPB
Coatomer subunit beta

2

6

High-throughput

0.606

High

943831

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

2

20

High-throughput

0.606

High

1119041

BYST
Bystin

2

1

High-throughput

0.606

High

1158610

CDC37
Hsp90 co-chaperone Cdc37

2

1

High-throughput

0.606

High

1180043

CCD57
Coiled-coil domain-containing protein 57

2

19

High-throughput

0.606

High

1214385

SYT6
Synaptotagmin-6

2

7

High-throughput

0.606

High

1225115

KANK2
KN motif and ankyrin repeat domain-containing protein 2

2

19

High-throughput

0.606

High

1228742

C102B
Coiled-coil domain-containing protein 102B

2

18

High-throughput

0.606

High

1239758

PPR18
Phostensin

2

14

High-throughput

0.606

High

1314952

CCD13
Coiled-coil domain-containing protein 13

2

19

High-throughput

0.606

High

1325262

TXLNB
Beta-taxilin

2

19

High-throughput

0.606

High

1327481

ZGPAT
Zinc finger CCCH-type with G patch domain-containing protein

2

3

High-throughput

0.606

High

1347417

LMO3
LIM domain only protein 3

2

16

High-throughput

0.606

High

1348583

LNX1
E3 ubiquitin-protein ligase LNX

2

16

High-throughput

0.606

High

1360532

PSPC1
Paraspeckle component 1

2

15

High-throughput

0.606

High

1371337

KAT5
Histone acetyltransferase KAT5

2

1

High-throughput

0.606

High

1385449

SYTL4
Synaptotagmin-like protein 4

2

6

High-throughput

0.606

High

1388516

ZMY19
Zinc finger MYND domain-containing protein 19

2

1

High-throughput

0.606

High

1412948

SYT17
Synaptotagmin-17

2

6

High-throughput

0.606

High

1417329

AP1M1
AP-1 complex subunit mu-1

2

7

High-throughput

0.606

High

1420317

TSG10
Testis-specific gene 10 protein

2

18

High-throughput

0.606

High

1430145

ENKD1
Enkurin domain-containing protein 1

2

2

High-throughput

0.606

High

1431529

CARD9
Caspase recruitment domain-containing protein 9

2

17

High-throughput

0.606

High

1437607

KIF9
Kinesin-like protein KIF9

2

20

High-throughput

0.606

High

1438800

NEK6
Serine/threonine-protein kinase Nek6

2

20

High-throughput

0.606

High

1448403

PICK1
PRKCA-binding protein

2

3

High-throughput

0.606

High

1460661

TRIM1
Probable E3 ubiquitin-protein ligase MID2

2

20

High-throughput

0.606

High

1490491

LSM2
U6 snRNA-associated Sm-like protein LSm2

2

2

High-throughput

0.606

High

1105191

U119A
Protein unc-119 homolog A

3

4

High-throughput

0.604

High

353761

DRC4
Dynein regulatory complex subunit 4

2

0

High-throughput

0.580

High

1208352

SPDYC
Speedy protein C

2

0

High-throughput

0.580

High

1253608

I23O2
Indoleamine 2,3-dioxygenase 2

2

0

High-throughput

0.580

High

1315155

EXOC8
Exocyst complex component 8

2

0

High-throughput

0.580

High

1390194

MCRS1
Microspherule protein 1

2

0

High-throughput

0.580

High

1462114

SUFU
Suppressor of fused homolog

2

0

High-throughput

0.580

High

688190

EF1G
Elongation factor 1-gamma

1

6

Small-scale

0.573

High

247041

KDM1A
Lysine-specific histone demethylase 1A

2

9

High-throughput

0.553

High

322882

MTCL2
Microtubule cross-linking factor 2

2

20

High-throughput

0.553

High

567197

ZNF35
Zinc finger protein 35

2

4

High-throughput

0.553

High

585114

ZN250
Zinc finger protein 250

2

1

High-throughput

0.553

High

600523

ZNF3
Zinc finger protein 3

2

3

High-throughput

0.553

High

681957

RBTN2
Rhombotin-2

2

16

High-throughput

0.553

High

682122

RBTN1
Rhombotin-1

2

16

High-throughput

0.553

High

935654

MFAP1
Microfibrillar-associated protein 1

2

1

High-throughput

0.553

High

965527

LMO4
LIM domain transcription factor LMO4

2

16

High-throughput

0.553

High

1042101

LMNB2
Lamin-B2

2

20

High-throughput

0.553

High

1055289

MTG8
Protein CBFA2T1

2

1

High-throughput

0.553

High

1124437

ELOA1
Elongin-A

2

8

High-throughput

0.553

High

1150189

TCEA2
Transcription elongation factor A protein 2

2

3

High-throughput

0.553

High

1180521

C19L2
CWF19-like protein 2

2

1

High-throughput

0.553

High

1185343

F161A
Protein FAM161A

2

3

High-throughput

0.553

High

1187706

T10IP
Testis-specific protein 10-interacting protein

2

1

High-throughput

0.553

High

1226852

KAZRN
Kazrin

2

5

High-throughput

0.553

High

1235036

PKHA7
Pleckstrin homology domain-containing family A member 7

2

20

High-throughput

0.553

High

1277135

ZN572
Zinc finger protein 572

2

5

High-throughput

0.553

High

1295133

F90A1
Protein FAM90A1

2

1

High-throughput

0.553

High

1309219

Q8IVT4
Hypothetical MGC50722

2

1

High-throughput

0.553

High

1328150

TTC9C
Tetratricopeptide repeat protein 9C

2

12

High-throughput

0.553

High

1347747

ZN417
Zinc finger protein 417

2

5

High-throughput

0.553

High

1350273

RHPN1
Rhophilin-1

2

12

High-throughput

0.553

High

1350747

CCHCR
Coiled-coil alpha-helical rod protein 1

2

19

High-throughput

0.553

High

1360269

MT21A
Protein N-lysine methyltransferase METTL21A

2

11

High-throughput

0.553

High

1368980

GOGA1
Golgin subfamily A member 1

2

17

High-throughput

0.553

High

1385279

LENG1
Leukocyte receptor cluster member 1

2

1

High-throughput

0.553

High

1392958

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

2

High-throughput

0.553

High

1393019

CC120
Coiled-coil domain-containing protein 120

2

2

High-throughput

0.553

High

1398660

F161B
Protein FAM161B

2

3

High-throughput

0.553

High

1402963

ZN587
Zinc finger protein 587

2

5

High-throughput

0.553

High

1406165

PRP18
Pre-mRNA-splicing factor 18

2

1

High-throughput

0.553

High

1415261

KIFC3
Kinesin-like protein KIFC3

2

7

High-throughput

0.553

High

1416199

SCNM1
Sodium channel modifier 1

2

1

High-throughput

0.553

High

1453952

TBCD7
TBC1 domain family member 7

2

3

High-throughput

0.553

High

1460025

RSP14
Radial spoke head 14 homolog

2

11

High-throughput

0.553

High

1460732

CDC23
Cell division cycle protein 23 homolog

2

4

High-throughput

0.553

High

1490489

FA50B
Protein FAM50B

2

1

High-throughput

0.553

High

1490492

CEP83
Centrosomal protein of 83 kDa

2

18

High-throughput

0.553

High

720711

AGTR1
Type-1 angiotensin II receptor

1

3

High-throughput

0.541

High

1363796

YLAT2
Y+L amino acid transporter 2

1

1

High-throughput

0.536

High

1454568

SI1L2
Signal-induced proliferation-associated 1-like protein 2

1

20

High-throughput

0.536

High

719389

MPIP3
M-phase inducer phosphatase 3

1

0

Small-scale

0.513

High

687318

HMGB2
High mobility group protein B2

1

11

High-throughput

0.508

High

1197130

AMOT
Angiomotin

1

18

High-throughput

0.481

High

1361183

PIBF1
Progesterone-induced-blocking factor 1

1

3

High-throughput

0.481

High

243316

PRKN
E3 ubiquitin-protein ligase parkin

1

13

High-throughput

0.479

High

323804

AP2A2
AP-2 complex subunit alpha-2

1

10

High-throughput

0.479

High

331428

KI20A
Kinesin-like protein KIF20A

1

20

High-throughput

0.479

High

401719

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

20

High-throughput

0.479

High

404553

GCR
Glucocorticoid receptor

1

20

High-throughput

0.479

High

443566

CDK1
Cyclin-dependent kinase 1

1

17

Small-scale

0.479

High

464299

FUMH
Fumarate hydratase, mitochondrial

1

3

High-throughput

0.479

High

845866

MUC18
Cell surface glycoprotein MUC18

1

9

High-throughput

0.479

High

872903

SOX2
Transcription factor SOX-2

1

9

High-throughput

0.479

High

936489

AFAD
Afadin

1

20

High-throughput

0.479

High

978413

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.479

High

1256141

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

1462001

ALK
ALK tyrosine kinase receptor

1

18

High-throughput

0.479

High

59937

A2BDD9
AMOT protein

1

18

High-throughput

0.470

High

1194599

Q4G0R1
PIBF1 protein

1

3

High-throughput

0.470

High

1119377

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

13

High-throughput

0.445

High

1397262

LURA1
Leucine rich adaptor protein 1

1

11

High-throughput

0.445

High

1332783

PMGT2
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

1

1

High-throughput

0.407

High

215210

PRPF3
U4/U6 small nuclear ribonucleoprotein Prp3

2

0

High-throughput

0.316

High

866402

MSS4
Guanine nucleotide exchange factor MSS4

2

0

High-throughput

0.316

High

956700

CKS1
Cyclin-dependent kinases regulatory subunit 1

2

0

High-throughput

0.316

High

1131912

COG2
Conserved oligomeric Golgi complex subunit 2

2

0

High-throughput

0.316

High

1287261

TBCD1
TBC1 domain family member 1

2

0

High-throughput

0.316

High

1370643

GPKOW
G-patch domain and KOW motifs-containing protein

2

0

High-throughput

0.316

High

1389710

SGF29
SAGA-associated factor 29

2

0

High-throughput

0.316

High

1396013

GAR1B
Golgi-associated RAB2 interactor protein 1B

2

0

High-throughput

0.316

High

1397229

FA81B
Protein FAM81B

2

0

High-throughput

0.316

High

1414286

RPC3
DNA-directed RNA polymerase III subunit RPC3

2

0

High-throughput

0.316

High

1357612

DCAF4
DDB1- and CUL4-associated factor 4

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025