HitPredict

Interactor 1: Q7KLE5 (Q7KLE5)
Amphiphysin (LD19810p)
Gene: Amph

Interactor 2: NEDD4 (Q9VVI3)
E3 ubiquitin-protein ligase Nedd-4 (DNedd4) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase NEDD4)
Gene: NEDD4

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.614

Property	Details
Experiments	26823013, 15710747
Identification Methods	affinity chromatography technology, two hybrid, two hybrid fragment pooling approach
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 602 Dm			1 1007
+	Dm
		1363736 Q9VDI1_DROME (403-600): 2.04e-19: 93.6: 22.33		NEDD4_DROME (1-1007): 0: 962: 100.00
+	Hs
		131270 BIN1_HUMAN (2-602): 8.58e-80: 264: 24.96		ITCH_HUMAN (56-1004): 0: 757: 29.56
+	Hs
		1078893 ITSN1_HUMAN (19-602): 5.67e-22: 103: 10.69		ITCH_HUMAN (56-1004): 0: 757: 29.56
+	Hs
		125573 ABI1_HUMAN (147-602): 2.56e-45: 169: 11.91		WWP2_HUMAN (289-1004): 0: 685: 35.40
+	Mm
		139040 BIN1_MOUSE (2-602): 6.61e-79: 262: 25.16		HUWE1_MOUSE (463-1005): 4.22e-161: 528: 33.33
+	Sc
		629630 RV161_YEAST (8-241): 2.96e-53: 184: 21.49		RSP5_YEAST (72-472): 1.42e-24: 112: 14.98
+	Hs
		282371 NEBL_HUMAN (1-602): 5.18e-42: 164: 10.82		SMUF2_HUMAN (71-464): 1.04e-30: 131: 16.88
+	Sc
		764057 RV167_YEAST (377-601): 6.4e-12: 70: 12.34		RSP5_YEAST (72-472): 1.42e-24: 112: 14.98