Protein: MK09
Mitogen-activated protein kinase 9 (MAP kinase 9) (MAPK 9) (EC 2.7.11.24) (JNK-55) (Stress-activated protein kinase 1a) (SAPK1a) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2)

Gene: MK09, MAPK9
Organism: Homo sapiens
Interactions: 169
UniProt ID: P45984

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0004705 - JUN kinase activity
GO:0004712 - protein serine/threonine/tyrosine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

800938

DUS16
Dual specificity protein phosphatase 16

8

20

Small-scale

0.970

High

800714

MK08
Mitogen-activated protein kinase 8

6

19

Small-scale

0.949

High

800968

DUS10
Dual specificity protein phosphatase 10

6

20

Small-scale

0.946

High

800858

MP2K4
Dual specificity mitogen-activated protein kinase kinase 4

5

20

Small-scale

0.924

High

800890

SF3B4
Splicing factor 3B subunit 4

4

10

High-throughput

0.911

High

800857

MK09
Mitogen-activated protein kinase 9

4

18

Small-scale

0.904

High

800879

DUS8
Dual specificity protein phosphatase 8

4

20

High-throughput

0.903

High

800936

RSLAB
Ras-like protein family member 10B

4

10

High-throughput

0.902

High

800934

LMBL3
Lethal(3)malignant brain tumor-like protein 3

3

2

High-throughput

0.871

High

304933

DUS14
Dual specificity protein phosphatase 14

3

20

High-throughput

0.861

High

338097

EGFR
Epidermal growth factor receptor

3

12

High-throughput

0.843

High

800878

DUS4
Dual specificity protein phosphatase 4

3

20

High-throughput

0.843

High

153098

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

3

20

Small-scale

0.820

High

800937

ZN559
Zinc finger protein 559

2

1

High-throughput

0.783

High

659259

DUS1
Dual specificity protein phosphatase 1

2

20

Small-scale

0.776

High

673552

MPIP3
M-phase inducer phosphatase 3

2

11

Small-scale

0.768

High

401593

JUN
Transcription factor Jun

19

20

Small-scale

0.767

High

800880

M3K1
Mitogen-activated protein kinase kinase kinase 1

2

19

Small-scale

0.767

High

547743

ATF2
Cyclic AMP-dependent transcription factor ATF-2

10

20

Small-scale

0.759

High

800864

ZN138
Zinc finger protein 138

2

0

High-throughput

0.742

High

800931

MCRS1
Microspherule protein 1

2

0

High-throughput

0.742

High

800872

M3K10
Mitogen-activated protein kinase kinase kinase 10

1

20

Small-scale

0.735

High

201914

WDR62
WD repeat-containing protein 62

5

14

Small-scale

0.730

High

800963

JIP1
C-Jun-amino-terminal kinase-interacting protein 1

5

9

Small-scale

0.728

High

685833

ARRB2
Beta-arrestin-2

5

8

High-throughput

0.724

High

800859

ARRB1
Beta-arrestin-1

5

8

High-throughput

0.722

High

800922

LNX1
E3 ubiquitin-protein ligase LNX

4

13

High-throughput

0.705

High

622099

ZBT25
Zinc finger and BTB domain-containing protein 25

1

2

High-throughput

0.698

High

800961

MACF1
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5

1

11

High-throughput

0.698

High

800862

MEOX1
Homeobox protein MOX-1

4

8

High-throughput

0.698

High

800865

MK10
Mitogen-activated protein kinase 10

1

17

High-throughput

0.691

High

800870

SRSF2
Serine/arginine-rich splicing factor 2

1

11

High-throughput

0.691

High

800886

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

14

High-throughput

0.691

High

800914

STK40
Serine/threonine-protein kinase 40

1

14

High-throughput

0.691

High

386271

P53
Cellular tumor antigen p53

4

11

Small-scale

0.683

High

584218

ELK1
ETS domain-containing protein Elk-1

3

17

Small-scale

0.682

High

800940

CEP44
Centrosomal protein of 44 kDa

4

0

High-throughput

0.675

High

713436

GLYC
Serine hydroxymethyltransferase, cytosolic

4

0

High-throughput

0.668

High

559010

H15
Histone H1.5

3

10

High-throughput

0.667

High

738730

SPB5
Serpin B5

3

4

High-throughput

0.667

High

800967

PKP3
Plakophilin-3

3

12

High-throughput

0.667

High

800919

DTX3
Probable E3 ubiquitin-protein ligase DTX3

4

0

High-throughput

0.663

High

800915

LNX2
Ligand of Numb protein X 2

3

13

High-throughput

0.658

High

800962

JIP3
C-Jun-amino-terminal kinase-interacting protein 3

3

19

Small-scale

0.651

High

673455

MPIP2
M-phase inducer phosphatase 2

1

11

Small-scale

0.647

High

681723

AKT1
RAC-alpha serine/threonine-protein kinase

1

20

Small-scale

0.647

High

800927

DUS19
Dual specificity protein phosphatase 19

1

20

Small-scale

0.647

High

800926

LRC15
Leucine-rich repeat-containing protein 15

3

0

High-throughput

0.638

High

800898

EFHC2
EF-hand domain-containing family member C2

4

11

High-throughput

0.637

High

230322

ZC3H1
Zinc finger C3H1 domain-containing protein

2

1

High-throughput

0.628

High

262389

TULP3
Tubby-related protein 3

2

4

High-throughput

0.628

High

800923

RHPN1
Rhophilin-1

2

7

High-throughput

0.628

High

800950

HXC10
Homeobox protein Hox-C10

2

8

High-throughput

0.628

High

226779

PRKN
E3 ubiquitin-protein ligase parkin

1

10

High-throughput

0.618

High

778974

CCNF
Cyclin-F

1

13

High-throughput

0.618

High

800860

KC1E
Casein kinase I isoform epsilon

1

14

High-throughput

0.618

High

800889

KPCD1
Serine/threonine-protein kinase D1

1

20

Small-scale

0.618

High

800943

PKHA4
Pleckstrin homology domain-containing family A member 4

1

9

High-throughput

0.618

High

800888

NFAC4
Nuclear factor of activated T-cells, cytoplasmic 4

1

12

Small-scale

0.613

High

800906

DSG4
Desmoglein-4

2

5

High-throughput

0.611

High

473052

BNIP5
Protein BNIP5

3

2

High-throughput

0.607

High

131398

IMA4
Importin subunit alpha-4

2

3

High-throughput

0.606

High

132767

SDCB1
Syntenin-1

2

13

High-throughput

0.606

High

180974

GSC2
Homeobox protein goosecoid-2

2

7

High-throughput

0.606

High

199177

ZNHI1
Zinc finger HIT domain-containing protein 1

2

2

High-throughput

0.606

High

208249

DCX
Neuronal migration protein doublecortin

2

1

High-throughput

0.606

High

535344

GFAP
Glial fibrillary acidic protein

2

7

High-throughput

0.606

High

740456

PPARG
Peroxisome proliferator-activated receptor gamma

2

15

High-throughput

0.606

High

800868

PO6F2
POU domain, class 6, transcription factor 2

2

2

High-throughput

0.606

High

800871

PAX5
Paired box protein Pax-5

2

5

High-throughput

0.606

High

800877

CDC16
Cell division cycle protein 16 homolog

2

3

High-throughput

0.606

High

800900

MLIP
Muscular LMNA-interacting protein

2

3

High-throughput

0.606

High

800918

CBLL2
E3 ubiquitin-protein ligase CBLL2

2

2

High-throughput

0.606

High

800939

PBX4
Pre-B-cell leukemia transcription factor 4

2

4

High-throughput

0.606

High

800952

KLHL8
Kelch-like protein 8

2

2

High-throughput

0.606

High

800954

LHX3
LIM/homeobox protein Lhx3

2

5

High-throughput

0.606

High

800964

LZTS1
Leucine zipper putative tumor suppressor 1

2

16

High-throughput

0.606

High

496514

TAU
Microtubule-associated protein tau

2

16

Small-scale

0.602

High

566735

JUNB
Transcription factor JunB

2

20

Small-scale

0.602

High

800867

GRB2
Growth factor receptor-bound protein 2

2

7

Small-scale

0.602

High

135847

WNT7A
Protein Wnt-7a

2

0

High-throughput

0.602

High

800933

ZN414
Zinc finger protein 414

2

0

High-throughput

0.602

High

716854

CTNB1
Catenin beta-1

1

11

Small-scale

0.598

High

800869

PRKDC
DNA-dependent protein kinase catalytic subunit

2

6

Small-scale

0.595

High

800884

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

2

10

Small-scale

0.584

High

800881

CENPR
Centromere protein R

2

0

High-throughput

0.580

High

800924

TCP1L
T-complex protein 10A homolog 1

2

0

High-throughput

0.580

High

800947

PICK1
PRKCA-binding protein

2

0

High-throughput

0.580

High

776600

STAT3
Signal transducer and activator of transcription 3

1

7

Small-scale

0.578

High

800863

TOB1
Protein Tob1

1

2

Small-scale

0.578

High

800904

TAFA3
Chemokine-like protein TAFA-3

2

1

High-throughput

0.574

High

800910

LRC56
Leucine-rich repeat-containing protein 56

2

3

High-throughput

0.574

High

800882

CTBP1
C-terminal-binding protein 1

1

4

High-throughput

0.573

High

800883

JIP2
C-Jun-amino-terminal kinase-interacting protein 2

1

12

Small-scale

0.561

High

800887

IRF3
Interferon regulatory factor 3

1

1

Small-scale

0.561

High

800959

HDAC9
Histone deacetylase 9

1

11

Small-scale

0.561

High

800894

RSPO4
R-spondin-4

2

3

High-throughput

0.553

High

800907

MD12L
Mediator of RNA polymerase II transcription subunit 12-like protein

2

8

High-throughput

0.553

High

800949

GOG6A
Golgin subfamily A member 6A

2

17

High-throughput

0.553

High

800946

XPP1
Xaa-Pro aminopeptidase 1

1

3

High-throughput

0.541

High

800957

XPO7
Exportin-7

1

3

High-throughput

0.541

High

568074

JUND
Transcription factor JunD

1

20

Small-scale

0.536

High

822

A0A096LNW4
PRAME family member 9

1

1

High-throughput

0.536

High

280030

MPDZ
Multiple PDZ domain protein

1

13

High-throughput

0.536

High

365166

FRIH
Ferritin heavy chain

1

1

High-throughput

0.536

High

532340

PPA5
Tartrate-resistant acid phosphatase type 5

1

0

High-throughput

0.518

High

800953

CE126
Centrosomal protein of 126 kDa

1

0

High-throughput

0.518

High

330236

BCL10
B-cell lymphoma/leukemia 10

1

1

Small-scale

0.515

High

800948

PP14D
Protein phosphatase 1 regulatory subunit 14D

1

0

High-throughput

0.513

High

225232

3BP5
SH3 domain-binding protein 5

1

2

Small-scale

0.501

High

537606

NCF1
Neutrophil cytosol factor 1

1

8

Small-scale

0.501

High

788160

CASP3
Caspase-3

1

9

Small-scale

0.501

High

800873

B2CL1
Bcl-2-like protein 1

1

13

Small-scale

0.501

High

800874

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

1

13

Small-scale

0.501

High

800929

JDP2
Jun dimerization protein 2

1

20

Small-scale

0.501

High

800966

FBX7
F-box only protein 7

1

1

High-throughput

0.501

High

58359

CI170
Uncharacterized protein encoded by LINC02872

1

1

High-throughput

0.489

High

800899

SPXN4
Sperm protein associated with the nucleus on the X chromosome N4

1

4

High-throughput

0.489

High

800920

F110D
Protein FAM110D

1

1

High-throughput

0.489

High

800956

CS025
UPF0449 protein C19orf25

1

1

High-throughput

0.489

High

800958

CC018
Uncharacterized protein C3orf18

1

1

High-throughput

0.489

High

800960

AT7L1
Ataxin-7-like protein 1

1

2

High-throughput

0.489

High

655264

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

3

Small-scale

0.484

High

500747

CLUS
Clusterin

1

1

High-throughput

0.481

High

800875

LMAN2
Vesicular integral-membrane protein VIP36

1

1

High-throughput

0.481

High

800876

NFAC3
Nuclear factor of activated T-cells, cytoplasmic 3

1

11

Small-scale

0.481

High

800945

SSU72
RNA polymerase II subunit A C-terminal domain phosphatase SSU72

1

1

High-throughput

0.481

High

800965

FBW1A
F-box/WD repeat-containing protein 1A

1

12

Small-scale

0.481

High

800861

PSN1
Presenilin-1

1

0

Small-scale

0.480

High

800930

NICA
Nicastrin

1

0

Small-scale

0.480

High

173377

ACOX3
Peroxisomal acyl-coenzyme A oxidase 3

1

1

High-throughput

0.479

High

345362

FOS
Protein c-Fos

1

20

High-throughput

0.479

High

561363

LYAM2
E-selectin

1

2

Small-scale

0.479

High

719900

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.479

High

800866

SEC13
Protein SEC13 homolog

1

3

High-throughput

0.479

High

800885

HDAC1
Histone deacetylase 1

1

7

Small-scale

0.479

High

800892

NF2L2
Nuclear factor erythroid 2-related factor 2

1

20

Small-scale

0.479

High

800893

NFE2
Transcription factor NF-E2 45 kDa subunit

1

20

Small-scale

0.479

High

800901

RN123
E3 ubiquitin-protein ligase RNF123

1

3

High-throughput

0.479

High

800913

AHI1
Jouberin

1

12

High-throughput

0.479

High

800921

RIN3
Ras and Rab interactor 3

1

10

High-throughput

0.479

High

800925

SH3R3
E3 ubiquitin-protein ligase SH3RF3

1

7

Small-scale

0.479

High

800928

STAB2
Stabilin-2

1

6

Small-scale

0.479

High

800935

SCLT1
Sodium channel and clathrin linker 1

1

14

High-throughput

0.479

High

800942

CDT1
DNA replication factor Cdt1

1

3

Small-scale

0.479

High

800944

DHX33
ATP-dependent RNA helicase DHX33

1

1

High-throughput

0.479

High

800951

WWOX
WW domain-containing oxidoreductase

1

3

Small-scale

0.479

High

800955

MALT1
Mucosa-associated lymphoid tissue lymphoma translocation protein 1

1

9

Small-scale

0.479

High

800896

NHSL2
NHS-like protein 2

1

5

High-throughput

0.470

High

277230

TUSC2
Tumor suppressor candidate 2

1

0

High-throughput

0.460

High

304801

MFN2
Mitofusin-2

1

0

Small-scale

0.458

High

800891

STIL
SCL-interrupting locus protein

1

0

High-throughput

0.458

High

800903

FBX42
F-box only protein 42

1

5

High-throughput

0.437

High

58370

SMCO3
Single-pass membrane and coiled-coil domain-containing protein 3

3

0

High-throughput

0.352

High

800909

TEX11
Testis-expressed protein 11

3

0

High-throughput

0.352

High

800905

CE024
UPF0461 protein C5orf24

2

0

High-throughput

0.328

High

800932

CC120
Coiled-coil domain-containing protein 120

2

0

High-throughput

0.328

High

316363

CA105
Uncharacterized protein C1orf105

2

0

High-throughput

0.316

High

800895

ZC21C
Zinc finger C2HC domain-containing protein 1C

2

0

High-throughput

0.316

High

800908

IHO1
Interactor of HORMAD1 protein 1

2

0

High-throughput

0.316

High

800911

SAXO1
Stabilizer of axonemal microtubules 1

2

0

High-throughput

0.316

High

800941

ENKD1
Enkurin domain-containing protein 1

2

0

High-throughput

0.316

High

800902

CA094
Uncharacterized protein C1orf94

1

0

High-throughput

0.299

High

631055

LAMA1
Laminin subunit alpha-1

1

0

High-throughput

0.279

Low

800897

CX066
Uncharacterized protein CXorf66

1

0

High-throughput

0.279

Low

800912

FAM9C
Protein FAM9C

1

0

High-throughput

0.279

Low

800917

CCD33
Coiled-coil domain-containing protein 33

1

0

High-throughput

0.251

Low

800916

SIM20
Small integral membrane protein 20

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024