HitPredict

Interactor 1: MARK2 (Q7KZI7)
Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b)
Gene: MARK2

Interactor 2: PARD3 (Q8TEW0)
Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha)
Gene: PARD3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	34079125, 22883624
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000226 - microtubule cytoskeleton organization GO:0005886 - plasma membrane GO:0030010 - establishment of cell polarity GO:0045197 - establishment or maintenance of epithelial cell apical/basal polarity
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 788 Hs			1 1356
+	Hs
		647930 MARK3_HUMAN (3-788): 0: 656: 60.40		PARD3_HUMAN (1-1356): 0: 709: 100.00
+	Hs
		1183080 MARK2_HUMAN (1-788): 0: 790: 100.00		PAR3L_HUMAN (1-1354): 5.88e-101: 352: 32.37
+	Hs
		647882 MARK3_HUMAN (3-788): 0: 656: 60.40		PTN13_HUMAN (39-368): 1.59e-16: 88.1: 12.50
+	Mm
		1193535 MARK4_MOUSE (3-788): 0: 572: 48.33		SCRIB_MOUSE (432-1330): 2.26e-33: 142: 11.83
+	Hs
		1050080 MARK1_HUMAN (3-788): 0: 644: 63.22		SCRIB_HUMAN (66-355): 5.59e-09: 63.1: 12.75
+	Hs
		1057190 MELK_HUMAN (44-788): 7.75e-161: 483: 25.03		MAGI1_HUMAN (354-780): 1.36e-16: 88.1: 14.16
+	Hs
		1025131 AAPK1_HUMAN (31-560): 4.31e-139: 424: 30.37		SCRIB_HUMAN (66-355): 5.59e-09: 63.1: 12.75
+	Ce
		1088790 PAR1_CAEEL (342-788): 3.04e-65: 238: 28.03		PAR3_CAEEL (2-1323): 7.36e-60: 228: 16.08