Protein: HG2A
HLA class II histocompatibility antigen gamma chain (HLA-DR antigens-associated invariant chain) (Ia antigen-associated invariant chain) (Ii) (CD antigen CD74) [Cleaved into: Class-II-associated invariant chain peptide (CLIP)]

Gene: HG2A, CD74
Organism: Homo sapiens
Interactions: 170
UniProt ID: P04233

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0001516 - prostaglandin biosynthetic process
GO:0001540 - amyloid-beta binding
GO:0001934 - positive regulation of protein phosphorylation
GO:0001961 - positive regulation of cytokine-mediated signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

380341

COPG2
Coatomer subunit gamma-2

4

1

High-throughput

0.699

High

380351

COPG1
Coatomer subunit gamma-1

4

1

High-throughput

0.699

High

380228

DPB1
HLA class II histocompatibility antigen, DP beta 1 chain

3

8

High-throughput

0.667

High

380303

T4S20
Transmembrane 4 L6 family member 20

3

0

High-throughput

0.638

High

123457

PGRC1
Membrane-associated progesterone receptor component 1

2

1

High-throughput

0.628

High

354656

DRA
HLA class II histocompatibility antigen, DR alpha chain

2

9

Small-scale

0.611

High

380317

CLD19
Claudin-19

2

5

High-throughput

0.606

High

380333

CLC7A
C-type lectin domain family 7 member A

2

2

High-throughput

0.606

High

380344

LPAR3
Lysophosphatidic acid receptor 3

2

1

High-throughput

0.606

High

380236

CD44
CD44 antigen

2

1

Small-scale

0.595

High

354803

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

2

9

Small-scale

0.584

High

70794

SMIM1
Small integral membrane protein 1

2

0

High-throughput

0.580

High

131864

UPK2
Uroplakin-2

2

0

High-throughput

0.580

High

169358

BET1
BET1 homolog

2

0

High-throughput

0.580

High

380232

PEPA4
Pepsin A-4

2

0

High-throughput

0.580

High

380252

FDFT
Squalene synthase

2

0

High-throughput

0.580

High

380270

MYPR
Myelin proteolipid protein

2

0

High-throughput

0.580

High

380291

PTC1
Protein patched homolog 1

2

0

High-throughput

0.580

High

380304

SGMR2
Sigma intracellular receptor 2

2

0

High-throughput

0.580

High

380307

RTP2
Receptor-transporting protein 2

2

0

High-throughput

0.580

High

380309

PLPP4
Phospholipid phosphatase 4

2

0

High-throughput

0.580

High

380315

TEX11
Testis-expressed protein 11

2

0

High-throughput

0.580

High

380318

NRAC
Nutritionally-regulated adipose and cardiac enriched protein homolog

2

0

High-throughput

0.580

High

380320

TM254
Transmembrane protein 254

2

0

High-throughput

0.580

High

380321

PMGT1
Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

2

0

High-throughput

0.580

High

380327

CKLF7
CKLF-like MARVEL transmembrane domain-containing protein 7

2

0

High-throughput

0.580

High

380332

TM243
Transmembrane protein 243

2

0

High-throughput

0.580

High

380335

FXYD6
FXYD domain-containing ion transport regulator 6

2

0

High-throughput

0.580

High

380336

TMM60
Transmembrane protein 60

2

0

High-throughput

0.580

High

380347

ERG28
Ergosterol biosynthetic protein 28 homolog

2

0

High-throughput

0.580

High

73052

B4DUJ2
cDNA FLJ54063, highly similar to Homo sapiens CD74 antigen, transcript variant 2, mRNA

1

1

High-throughput

0.575

High

380226

HG2A
HLA class II histocompatibility antigen gamma chain

1

10

Small-scale

0.575

High

380253

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

2

1

High-throughput

0.560

High

380247

CCR1
C-C chemokine receptor type 1

1

4

High-throughput

0.541

High

380235

MIF
Macrophage migration inhibitory factor

1

0

Small-scale

0.537

High

124716

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

1

High-throughput

0.536

High

150155

AP3D1
AP-3 complex subunit delta-1

1

2

High-throughput

0.536

High

170768

PGRC2
Membrane-associated progesterone receptor component 2

1

1

High-throughput

0.536

High

176913

EIF3H
Eukaryotic translation initiation factor 3 subunit H

1

1

High-throughput

0.536

High

303993

UBR5
E3 ubiquitin-protein ligase UBR5

1

2

High-throughput

0.536

High

380234

PCNA
Proliferating cell nuclear antigen

1

1

High-throughput

0.536

High

380241

1433T
14-3-3 protein theta

1

4

High-throughput

0.536

High

380246

1433B
14-3-3 protein beta/alpha

1

4

High-throughput

0.536

High

380250

COPB2
Coatomer subunit beta'

1

1

High-throughput

0.536

High

380256

MTOR
Serine/threonine-protein kinase mTOR

1

1

High-throughput

0.536

High

380257

CNDD3
Condensin-2 complex subunit D3

1

1

High-throughput

0.536

High

380260

PRC2A
Protein PRRC2A

1

3

High-throughput

0.536

High

380262

DGKE
Diacylglycerol kinase epsilon

1

1

High-throughput

0.536

High

380263

COPB
Coatomer subunit beta

1

1

High-throughput

0.536

High

380264

COPA
Coatomer subunit alpha

1

1

High-throughput

0.536

High

380276

1433Z
14-3-3 protein zeta/delta

1

4

High-throughput

0.536

High

380277

IF4G2
Eukaryotic translation initiation factor 4 gamma 2

1

2

High-throughput

0.536

High

380280

DRB3
HLA class II histocompatibility antigen, DR beta 3 chain

1

8

High-throughput

0.536

High

380283

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

1

2

High-throughput

0.536

High

380284

TF3C1
General transcription factor 3C polypeptide 1

1

1

High-throughput

0.536

High

380286

EI2BE
Translation initiation factor eIF2B subunit epsilon

1

2

High-throughput

0.536

High

380288

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

1

High-throughput

0.536

High

380292

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

1

High-throughput

0.536

High

380299

CND1
Condensin complex subunit 1

1

1

High-throughput

0.536

High

380302

PDCD4
Programmed cell death protein 4

1

2

High-throughput

0.536

High

380305

PP6R3
Serine/threonine-protein phosphatase 6 regulatory subunit 3

1

1

High-throughput

0.536

High

380308

UBR4
E3 ubiquitin-protein ligase UBR4

1

1

High-throughput

0.536

High

380314

DDX60
Probable ATP-dependent RNA helicase DDX60

1

1

High-throughput

0.536

High

380319

ASCC1
Activating signal cointegrator 1 complex subunit 1

1

1

High-throughput

0.536

High

380330

TBA1C
Tubulin alpha-1C chain

1

1

High-throughput

0.536

High

380338

EI2BG
Translation initiation factor eIF2B subunit gamma

1

1

High-throughput

0.536

High

380340

DJB12
DnaJ homolog subfamily B member 12

1

1

High-throughput

0.536

High

380348

PP6R1
Serine/threonine-protein phosphatase 6 regulatory subunit 1

1

1

High-throughput

0.536

High

380350

PRC2C
Protein PRRC2C

1

2

High-throughput

0.536

High

380240

CXCR2
C-X-C chemokine receptor type 2

1

3

Small-scale

0.515

High

380273

CXCR4
C-X-C chemokine receptor type 4

1

3

Small-scale

0.515

High

59083

VWA8
von Willebrand factor A domain-containing protein 8

1

0

High-throughput

0.513

High

149520

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.513

High

155978

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

0

High-throughput

0.513

High

176700

EIF3D
Eukaryotic translation initiation factor 3 subunit D

1

0

High-throughput

0.513

High

198519

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

0

High-throughput

0.513

High

215566

AKAP8
A-kinase anchor protein 8

1

0

High-throughput

0.513

High

297145

IPO13
Importin-13

1

0

High-throughput

0.513

High

380230

IF2A
Eukaryotic translation initiation factor 2 subunit 1

1

0

High-throughput

0.513

High

380231

ASNS
Asparagine synthetase [glutamine-hydrolyzing]

1

0

High-throughput

0.513

High

380237

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

0

High-throughput

0.513

High

380242

CALX
Calnexin

1

0

High-throughput

0.513

High

380244

TPP2
Tripeptidyl-peptidase 2

1

0

High-throughput

0.513

High

380251

PRS7
26S proteasome regulatory subunit 7

1

0

High-throughput

0.513

High

380254

IF2G
Eukaryotic translation initiation factor 2 subunit 3

1

0

High-throughput

0.513

High

380258

MAP1B
Microtubule-associated protein 1B

1

0

High-throughput

0.513

High

380259

COPD
Coatomer subunit delta

1

0

High-throughput

0.513

High

380266

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

0

High-throughput

0.513

High

380268

GEMI4
Gem-associated protein 4

1

0

High-throughput

0.513

High

380271

EIF3E
Eukaryotic translation initiation factor 3 subunit E

1

0

High-throughput

0.513

High

380272

IF4A1
Eukaryotic initiation factor 4A-I

1

0

High-throughput

0.513

High

380274

1433E
14-3-3 protein epsilon

1

0

High-throughput

0.513

High

380275

RUXE
Small nuclear ribonucleoprotein E

1

0

High-throughput

0.513

High

380278

GTF2I
General transcription factor II-I

1

0

High-throughput

0.513

High

380285

CAF1B
Chromatin assembly factor 1 subunit B

1

0

High-throughput

0.513

High

380289

HAP28
28 kDa heat- and acid-stable phosphoprotein

1

0

High-throughput

0.513

High

380290

IQGA2
Ras GTPase-activating-like protein IQGAP2

1

0

High-throughput

0.513

High

380293

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

0

High-throughput

0.513

High

380294

GANAB
Neutral alpha-glucosidase AB

1

0

High-throughput

0.513

High

380295

IMB1
Importin subunit beta-1

1

0

High-throughput

0.513

High

380312

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

0

High-throughput

0.513

High

380313

MIRO2
Mitochondrial Rho GTPase 2

1

0

High-throughput

0.513

High

380316

ASCC3
Activating signal cointegrator 1 complex subunit 3

1

0

High-throughput

0.513

High

380325

ROP1L
Ropporin-1-like protein

1

0

High-throughput

0.513

High

380326

ASTRA
Protein Aster-A

1

0

High-throughput

0.513

High

380342

EIF3K
Eukaryotic translation initiation factor 3 subunit K

1

0

High-throughput

0.513

High

380343

DJB11
DnaJ homolog subfamily B member 11

1

0

High-throughput

0.513

High

380345

ZO2
Tight junction protein ZO-2

1

0

High-throughput

0.513

High

380346

EI2BD
Translation initiation factor eIF2B subunit delta

1

0

High-throughput

0.513

High

380349

EIF3L
Eukaryotic translation initiation factor 3 subunit L

1

0

High-throughput

0.513

High

380287

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

1

Small-scale

0.501

High

380298

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

1

High-throughput

0.489

High

380301

UBE3C
Ubiquitin-protein ligase E3C

1

1

High-throughput

0.489

High

380306

PRC2B
Protein PRRC2B

1

3

High-throughput

0.489

High

380229

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

380233

HS71A
Heat shock 70 kDa protein 1A

1

0

Small-scale

0.480

High

275775

EIF3G
Eukaryotic translation initiation factor 3 subunit G

1

1

High-throughput

0.479

High

355007

DQB1
HLA class II histocompatibility antigen, DQ beta 1 chain

1

6

Small-scale

0.479

High

380227

K2C1
Keratin, type II cytoskeletal 1

1

3

High-throughput

0.479

High

380238

DPA1
HLA class II histocompatibility antigen, DP alpha 1 chain

1

9

Small-scale

0.479

High

380239

VDAC1
Voltage-dependent anion-selective channel protein 1

1

1

High-throughput

0.479

High

380245

HMOX2
Heme oxygenase 2

1

1

High-throughput

0.479

High

380249

PHB1
Prohibitin 1

1

1

High-throughput

0.479

High

380255

EIF1
Eukaryotic translation initiation factor 1

1

1

High-throughput

0.479

High

380281

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.479

High

380282

IRF8
Interferon regulatory factor 8

1

1

Small-scale

0.479

High

380297

CND2
Condensin complex subunit 2

1

1

High-throughput

0.479

High

380310

TBA1A
Tubulin alpha-1A chain

1

1

High-throughput

0.479

High

380334

OSBL8
Oxysterol-binding protein-related protein 8

1

2

High-throughput

0.479

High

380339

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

1

High-throughput

0.479

High

206313

LTOR5
Ragulator complex protein LAMTOR5

1

0

Small-scale

0.460

High

380248

C2TA
MHC class II transactivator

1

0

Small-scale

0.458

High

380296

CUL7
Cullin-7

1

0

High-throughput

0.458

High

87406

C9JI87
Voltage-dependent anion-selective channel protein 1

1

1

High-throughput

0.445

High

87562

C9JW96
Prohibitin

1

1

High-throughput

0.445

High

92756

E9PS44
Interferon induced transmembrane protein 3

1

1

High-throughput

0.445

High

101664

F8VUA7
Oxysterol-binding protein

1

2

High-throughput

0.445

High

110758

H6VRG2
Keratin, type II cytoskeletal 1

1

3

High-throughput

0.445

High

135333

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

1

2

High-throughput

0.445

High

150025

IF1AY
Eukaryotic translation initiation factor 1A, Y-chromosomal

1

1

High-throughput

0.445

High

354920

DRB1
HLA class II histocompatibility antigen, DRB1 beta chain

1

8

High-throughput

0.445

High

380243

DMA
HLA class II histocompatibility antigen, DM alpha chain

1

9

Small-scale

0.445

High

380323

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

2

High-throughput

0.445

High

380311

EIF3M
Eukaryotic translation initiation factor 3 subunit M

1

1

High-throughput

0.437

High

112110

M0QYT0
RRM domain-containing protein

1

0

High-throughput

0.426

High

380269

DSCR9
Down syndrome critical region protein 9

1

1

High-throughput

0.417

High

87276

C9J470
Condensin complex subunit 2

1

1

High-throughput

0.407

High

101659

F8VRU2
DNA-directed RNA polymerase

1

1

High-throughput

0.407

High

108840

H0YCQ8
Eukaryotic translation initiation factor 3 subunit M

1

1

High-throughput

0.407

High

111100

I3L4P8
Heme oxygenase 2

1

1

High-throughput

0.407

High

111573

K7EL20
Eukaryotic translation initiation factor 3 subunit G

1

1

High-throughput

0.407

High

239475

EIF1B
Eukaryotic translation initiation factor 1b

1

1

High-throughput

0.407

High

49295

T120B
Transmembrane protein 120B

2

0

High-throughput

0.316

High

380267

EP3B
Epididymal secretory protein E3-beta

2

0

High-throughput

0.316

High

380279

S35B1
Solute carrier family 35 member B1

2

0

High-throughput

0.316

High

380328

SC22A
Vesicle-trafficking protein SEC22a

2

0

High-throughput

0.316

High

380352

SERP1
Stress-associated endoplasmic reticulum protein 1

2

0

High-throughput

0.316

High

166873

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

1

0

High-throughput

0.279

Low

275969

EIF3J
Eukaryotic translation initiation factor 3 subunit J

1

0

High-throughput

0.279

Low

296850

LTN1
E3 ubiquitin-protein ligase listerin

1

0

High-throughput

0.279

Low

314938

SGPL1
Sphingosine-1-phosphate lyase 1

1

0

High-throughput

0.279

Low

380261

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.279

Low

380265

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

0

High-throughput

0.279

Low

380300

RCN1
Reticulocalbin-1

1

0

High-throughput

0.279

Low

380324

FAKD4
FAST kinase domain-containing protein 4

1

0

High-throughput

0.279

Low

380329

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

0

High-throughput

0.279

Low

380337

RWDD1
RWD domain-containing protein 1

1

0

High-throughput

0.279

Low

380331

CNPY3
Protein canopy homolog 3

1

0

Small-scale

0.249

Low

380322

ALG3
Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase

1

0

Small-scale

0.238

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024