HitPredict

Interactor 1: G2E3 (Q7L622)
G2/M phase-specific E3 ubiquitin-protein ligase (EC 2.3.2.26) (G2/M phase-specific HECT-type E3 ubiquitin transferase)
Gene: G2E3

Interactor 2: WDR6 (Q9NNW5)
tRNA (34-2'-O)-methyltransferase regulator WDR6 (WD repeat-containing protein 6)
Gene: WDR6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.55	0.60	0.576

Property	Details
Experiments	16189514, 31515488
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 706 Hs			1 1121
+	Hs
		1162581 G2E3_HUMAN (1-706): 0: 1119: 100.00		Q6PKC6_HUMAN (402-623): 1.31e-10: 65.5: 11.93
+	Hs
		1288387 KMT2B_HUMAN (10-128): 3.3e-33: 139: 24.37		SNR40_HUMAN (200-348): 7.65e-10: 64: 26.58
+	Hs
		1268048 JADE3_HUMAN (12-137): 5.02e-33: 138: 22.56		SNR40_HUMAN (200-348): 7.65e-10: 64: 26.58
+	Hs
		903604 KMT2B_HUMAN (10-128): 3.3e-33: 139: 24.37		WDR5_HUMAN (390-646): 7.51e-09: 60.7: 13.53
+	At
		1319861 ATX1_ARATH (5-145): 6.85e-30: 128: 18.59		WDR5A_ARATH (12-88): 8.93e-11: 66.6: 5.00
+	Hs
		301131 KDM4B_HUMAN (13-135): 2.76e-27: 120: 19.08		WDR5_HUMAN (390-646): 7.51e-09: 60.7: 13.53
+	Hs
		1288363 TCF20_HUMAN (18-154): 1.6e-24: 112: 19.44		SNR40_HUMAN (200-348): 7.65e-10: 64: 26.58
+	Hs
		1219301 PHF6_HUMAN (2-128): 1.2e-19: 93.3: 28.24		FBXW7_HUMAN (603-914): 3.98e-13: 76: 13.75
+	Hs
		975303 KMT2A_HUMAN (104-303): 7.44e-15: 80.9: 15.17		FBXW7_HUMAN (603-914): 3.98e-13: 76: 13.75
+	Mm
		903669 KMT2C_MOUSE (78-310): 3.22e-10: 65.9: 15.32		WDR5_MOUSE (866-1120): 9.89e-19: 90.9: 12.55
+	Hs
		152678 KMT2D_HUMAN (77-287): 2.9e-12: 72.8: 15.49		FBXW7_HUMAN (603-914): 3.98e-13: 76: 13.75
+	Hs
		975304 KMT2A_HUMAN (104-303): 7.44e-15: 80.9: 15.17		SNR40_HUMAN (200-348): 7.65e-10: 64: 26.58
+	Hs
		903149 KMT2A_HUMAN (104-303): 7.44e-15: 80.9: 15.17		WDR5_HUMAN (390-646): 7.51e-09: 60.7: 13.53
+	Hs
		152663 KMT2D_HUMAN (77-287): 2.9e-12: 72.8: 15.49		WDR5B_HUMAN (390-646): 2.24e-09: 62.2: 12.78
+	Hs
		152622 KMT2D_HUMAN (77-287): 2.9e-12: 72.8: 15.49		WDR5_HUMAN (390-646): 7.51e-09: 60.7: 13.53
+	Hs
		903374 KMT2C_HUMAN (78-314): 1.39e-10: 67.1: 15.92		WDR5_HUMAN (390-646): 7.51e-09: 60.7: 13.53