HitPredict

Interactor 1: NT2NA (Q7Z3S9)
Notch homolog 2 N-terminal-like protein A (Notch homolog 2 N-terminal-like protein)
Gene: NOTCH2NLA

Interactor 2: NECT3 (Q9NQS3)
Nectin-3 (CDw113) (Nectin cell adhesion molecule 3) (Poliovirus receptor-related protein 3) (CD antigen CD113)
Gene: NECTIN3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.80	0.770

Property	Details
Experiments	25416956, 32296183, 31515488
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	EGF~V-set
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 236 Hs			1 549
+	Hs
		484720 NT2NC_HUMAN (69-233): 8.71e-14: 70.8: 32.95		NECT3_HUMAN (49-549): 5.39e-105: 327: 100.00
+	Hs
		1189382 NT2NA_HUMAN (1-236): 1e-44: 151: 100.00		NECT2_HUMAN (25-360): 1.8e-62: 215: 28.81
+	Ce
		103935 SLIT1_CAEEL (86-233): 3.34e-21: 93.9: 27.74		SAX3_CAEEL (10-520): 1.71e-58: 212: 12.10
+	Dm
		621596 SLIT_DROME (68-233): 1.89e-31: 123: 33.53		Q9VQ08_DROME (120-549): 1.4e-44: 171: 12.25
+	Dm
		219803 SLIT_DROME (68-233): 1.89e-31: 123: 33.53		O44924_DROME (171-548): 4.79e-44: 169: 11.36
+	Dm
		621597 SLIT_DROME (68-233): 1.89e-31: 123: 33.53		Q9W213_DROME (171-548): 7.07e-44: 169: 11.36
+	Dm
		621592 SLIT_DROME (68-233): 1.89e-31: 123: 33.53		Q9GPP7_DROME (171-549): 2.14e-43: 167: 12.07
+	Hs
		484677 NT2NC_HUMAN (69-233): 8.71e-14: 70.8: 32.95		NECT2_HUMAN (25-360): 1.8e-62: 215: 28.81
+	Hs
		804225 NOTC1_HUMAN (67-233): 4.88e-17: 81.9: 29.94		CNTN1_HUMAN (56-506): 2.46e-45: 173: 13.79
+	Hs
		980365 NOTC2_HUMAN (8-180): 9.42e-16: 78.1: 27.84		CNTN1_HUMAN (56-506): 2.46e-45: 173: 13.79
+	Mm
		1112695 TEN4_MOUSE (98-235): 1.09e-21: 95.5: 21.58		PTK7_MOUSE (172-548): 1.66e-38: 153: 12.71
+	Dm
		621591 SLIT_DROME (68-233): 1.89e-31: 123: 33.53		Q9GPP6_DROME (2-500): 1.09e-25: 114: 12.04
+	Dm
		621595 SLIT_DROME (68-233): 1.89e-31: 123: 33.53		Q9VPZ7_DROME (2-500): 9.42e-26: 114: 12.04
+	Hs
		980481 NOTC2_HUMAN (8-180): 9.42e-16: 78.1: 27.84		PXDN_HUMAN (246-541): 2.46e-35: 143: 11.26
+	Hs
		545132 NT2NA_HUMAN (1-236): 1e-44: 151: 100.00		PVR_HUMAN (2-269): 4.78e-10: 63.8: 13.33
+	Dm
		247106 TENM_DROME (2-124): 1.24e-14: 74.7: 17.71		Q9VMN9_DROME (2-256): 1.02e-24: 108: 15.00
+	Mm
		292557 SLIT3_MOUSE (71-188): 8.65e-12: 66.2: 27.05		ROBO1_MOUSE (253-548): 4.67e-25: 112: 10.63
+	Hs
		296682 SLIT2_HUMAN (68-185): 2.64e-10: 62: 32.52		ROBO1_HUMAN (264-548): 5.78e-25: 112: 10.39
+	Dm
		422809 NOTCH_DROME (10-236): 6.06e-15: 75.8: 21.99		Q9BN17_DROME (231-477): 6.38e-18: 90: 12.86
+	Hs
		484560 NT2NC_HUMAN (69-233): 8.71e-14: 70.8: 32.95		PVR_HUMAN (2-269): 4.78e-10: 63.8: 13.33