HitPredict

Interactor 1: PIWL4 (Q7Z3Z4)
Piwi-like protein 4
Gene: PIWIL4

Interactor 2: DICER (Q9UPY3)
Endoribonuclease Dicer (EC 3.1.26.3) (Helicase with RNase motif) (Helicase MOI)
Gene: DICER1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.55	1.00	0.743

Property	Details
Experiments	12906857, 14749716
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PAZ~PAZ, PAZ~Ribonuclease_3, PAZ~Piwi
Common GO terms	GO:0004521 - RNA endonuclease activity GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 852 Hs			1 1922
+	Hs
		1294948 PIWL1_HUMAN (15-852): 0: 977: 49.23		DICER_HUMAN (1-1922): 0: 1763: 100.00
+	Mm
		1246887 PIWL1_MOUSE (15-852): 0: 959: 48.99		DICER_MOUSE (1-1922): 0: 1774: 92.88
+	Mm
		1208646 AGO2_MOUSE (79-845): 0: 916: 21.49		DICER_MOUSE (1-1922): 0: 1774: 92.88
+	Hs
		1356627 AGO2_HUMAN (90-845): 0: 915: 21.78		DICER_HUMAN (1-1922): 0: 1763: 100.00
+	Hs
		1356717 AGO1_HUMAN (88-837): 0: 902: 21.89		DICER_HUMAN (1-1922): 0: 1763: 100.00
+	Hs
		1334291 AGO3_HUMAN (84-845): 0: 900: 21.03		DICER_HUMAN (1-1922): 0: 1763: 100.00
+	Hs
		1253320 PIWL2_HUMAN (2-852): 0: 898: 35.10		DICER_HUMAN (1-1922): 0: 1763: 100.00
+	Ce
		108452 G5EGR6_CAEEL (30-837): 0: 890: 19.31		DCR1_CAEEL (42-1918): 0: 1083: 30.31
+	Hs
		1286222 AGO2_HUMAN (90-845): 0: 915: 21.78		DHX58_HUMAN (43-638): 2.57e-80: 282: 21.70
+	Ce
		106110 G5EGR6_CAEEL (30-837): 0: 890: 19.31		G5EDI8_CAEEL (15-727): 2.24e-79: 288: 18.30
+	Hs
		571629 AGO2_HUMAN (90-845): 0: 915: 21.78		DDX5_HUMAN (6-364): 3.03e-66: 239: 11.54
+	Hs
		571630 AGO1_HUMAN (88-837): 0: 902: 21.89		DDX5_HUMAN (6-364): 3.03e-66: 239: 11.54
+	Hs
		757796 AGO2_HUMAN (90-845): 0: 915: 21.78		IF4A3_HUMAN (6-251): 1.27e-52: 193: 11.37
+	Hs
		757797 AGO1_HUMAN (88-837): 0: 902: 21.89		IF4A3_HUMAN (6-251): 1.27e-52: 193: 11.37
+	Ce
		108574 G5EGR6_CAEEL (30-837): 0: 890: 19.31		Q9BL61_CAEEL (9-280): 2.7e-55: 200: 12.81
+	Ce
		108443 G5EGR6_CAEEL (30-837): 0: 890: 19.31		IF4A_CAEEL (20-397): 8.98e-55: 199: 11.57
+	Ce
		108423 G5EGR6_CAEEL (30-837): 0: 890: 19.31		O44781_CAEEL (9-280): 1.63e-54: 198: 12.81
+	Hs
		272303 AGO1_HUMAN (88-837): 0: 902: 21.89		U520_HUMAN (4-505): 1.16e-29: 132: 10.93
+	Dm
		1103836 Q32KD4_DROME (9-837): 0: 902: 19.65		DCR1_DROME (1582-1767): 1.61e-11: 72.3: 20.41
+	Dm
		1182893 Q7KY08_DROME (9-837): 0: 901: 19.65		DCR1_DROME (1582-1767): 1.61e-11: 72.3: 20.41