Protein: ZN516
Zinc finger protein 516

Gene: ZN516, ZNF516
Organism: Homo sapiens
Interactions: 63
UniProt ID: Q92618

Gene Ontology (top 5):
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 - cis-regulatory region sequence-specific DNA binding
GO:0005634 - nucleus
GO:0006355 - regulation of DNA-templated transcription

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

74357

ZBT42
Zinc finger and BTB domain-containing protein 42

2

19

High-throughput

0.811

High

1365826

DYR1B
Dual specificity tyrosine-phosphorylation-regulated kinase 1B

2

3

High-throughput

0.811

High

1365821

KLF15
Krueppel-like factor 15

2

20

High-throughput

0.754

High

1109949

HDAC1
Histone deacetylase 1

7

8

Small-scale

0.749

High

1103296

CTBP1
C-terminal-binding protein 1

7

7

Small-scale

0.747

High

339811

KLF8
Krueppel-like factor 8

1

20

High-throughput

0.691

High

1365812

ZBT18
Zinc finger and BTB domain-containing protein 18

1

12

High-throughput

0.691

High

1365815

PRD16
Histone-lysine N-methyltransferase PRDM16

1

7

High-throughput

0.691

High

246821

KDM1A
Lysine-specific histone demethylase 1A

4

4

Small-scale

0.686

High

1365822

RCOR1
REST corepressor 1

3

6

Small-scale

0.667

High

941508

CTBP2
C-terminal-binding protein 2

2

7

Small-scale

0.628

High

1365807

HDAC2
Histone deacetylase 2

2

8

Small-scale

0.628

High

216970

KLF4
Krueppel-like factor 4

1

19

High-throughput

0.618

High

790073

ZEB1
Zinc finger E-box-binding homeobox 1

1

19

Small-scale

0.618

High

944711

KLF3
Krueppel-like factor 3

1

19

High-throughput

0.618

High

1040869

MECOM
Histone-lysine N-methyltransferase MECOM

1

15

High-throughput

0.618

High

1351100

SP7
Transcription factor Sp7

1

19

High-throughput

0.618

High

1365827

KLF12
Krueppel-like factor 12

1

20

High-throughput

0.618

High

1365811

LCOR
Ligand-dependent corepressor

2

0

High-throughput

0.602

High

407675

S100B
Protein S100-B

2

4

High-throughput

0.601

High

245639

ZEB2
Zinc finger E-box-binding homeobox 2

1

19

Small-scale

0.575

High

1104622

IKZF1
DNA-binding protein Ikaros

1

11

High-throughput

0.575

High

1365820

SMBT1
Scm-like with four MBT domains protein 1

1

1

High-throughput

0.536

High

1365823

MED23
Mediator of RNA polymerase II transcription subunit 23

1

0

High-throughput

0.530

High

1161969

H31T
Histone H3.1t

1

11

Small-scale

0.501

High

1365813

ZBP1
Z-DNA-binding protein 1

1

0

High-throughput

0.493

High

143148

NFIB
Nuclear factor 1 B-type

1

18

High-throughput

0.479

High

363655

EGFR
Epidermal growth factor receptor

1

3

High-throughput

0.479

High

404282

GCR
Glucocorticoid receptor

1

17

High-throughput

0.479

High

414322

P53
Cellular tumor antigen p53

1

6

High-throughput

0.479

High

474162

NFIC
Nuclear factor 1 C-type

1

18

High-throughput

0.479

High

589301

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

662471

GATA2
Endothelial transcription factor GATA-2

1

3

High-throughput

0.479

High

685286

PAX6
Paired box protein Pax-6

1

5

High-throughput

0.479

High

697203

APEX1
DNA repair nuclease/redox regulator APEX1

1

1

High-throughput

0.479

High

703177

TEAD1
Transcriptional enhancer factor TEF-1

1

3

High-throughput

0.479

High

714308

PML
Protein PML

1

20

High-throughput

0.479

High

725293

TLX1
T-cell leukemia homeobox protein 1

1

10

High-throughput

0.479

High

887067

CEBPA
CCAAT/enhancer-binding protein alpha

1

6

High-throughput

0.479

High

942456

GSC
Homeobox protein goosecoid

1

7

High-throughput

0.479

High

1087901

NFIA
Nuclear factor 1 A-type

1

18

High-throughput

0.479

High

1133564

NFIX
Nuclear factor 1 X-type

1

18

High-throughput

0.479

High

1314335

SLX4
Structure-specific endonuclease subunit SLX4

1

1

High-throughput

0.479

High

1365809

PF21A
PHD finger protein 21A

1

14

High-throughput

0.479

High

1365818

VSX1
Visual system homeobox 1

1

8

High-throughput

0.479

High

1365819

ZMYM2
Zinc finger MYM-type protein 2

1

2

High-throughput

0.479

High

1365824

LHX6
LIM/homeobox protein Lhx6

1

6

High-throughput

0.479

High

1365825

ASF1A
Histone chaperone ASF1A

1

1

High-throughput

0.479

High

995175

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.458

High

1181251

ZN750
Zinc finger protein 750

1

0

Small-scale

0.458

High

1276570

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1365816

HYPK
Huntingtin-interacting protein K

1

0

Small-scale

0.458

High

1066422

RBBP4
Histone-binding protein RBBP4

1

3

Small-scale

0.445

High

1158945

RBBP7
Histone-binding protein RBBP7

1

3

Small-scale

0.445

High

1365808

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

6

Small-scale

0.445

High

1365810

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

4

Small-scale

0.445

High

1365817

GRHL1
Grainyhead-like protein 1 homolog

1

1

High-throughput

0.445

High

106377

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

964693

DCAF7
DDB1- and CUL4-associated factor 7

1

5

High-throughput

0.437

High

317738

NOL4
Nucleolar protein 4

1

0

High-throughput

0.279

Low

191029

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

High-throughput

0.249

Low

160569

IRS4
Insulin receptor substrate 4

1

0

Small-scale

0.232

Low

1365814

MANS1
MANSC domain-containing protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025