HitPredict

Interactor 1: MAVS (Q7Z434)
Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA)
Gene: MAVS

Interactor 2: RN166 (Q96A37)
E3 ubiquitin-protein ligase RNF166 (EC 2.3.2.27) (RING finger protein 166) (RING-type E3 ubiquitin transferase RNF166)
Gene: RNF166

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	26456228
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0045087 - innate immune response
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 540 Hs			1 237
+	Hs
		1190139 MAVS_HUMAN (1-540): 1.73e-73: 245: 100.00		RN114_HUMAN (18-236): 1.44e-49: 163: 46.12
+	Hs
		1190056 MAVS_HUMAN (1-540): 1.73e-73: 245: 100.00		RN125_HUMAN (6-236): 1.1e-41: 143: 30.67
+	Hs
		1024700 MAVS_HUMAN (1-540): 1.73e-73: 245: 100.00		TRAF3_HUMAN (15-215): 4.28e-31: 121: 20.29
+	Hs
		129573 MAVS_HUMAN (1-540): 1.73e-73: 245: 100.00		TRAF5_HUMAN (12-237): 8.71e-31: 120: 21.21
+	Hs
		584997 MAVS_HUMAN (1-540): 1.73e-73: 245: 100.00		RO52_HUMAN (19-166): 8.73e-31: 120: 20.95
+	Hs
		1190136 MAVS_HUMAN (1-540): 1.73e-73: 245: 100.00		TRAF6_HUMAN (8-235): 8.66e-29: 114: 17.83
+	Hs
		1020764 MAVS_HUMAN (1-540): 1.73e-73: 245: 100.00		TRAF2_HUMAN (15-186): 9.47e-27: 109: 20.65
+	Hs
		1190082 MAVS_HUMAN (1-540): 1.73e-73: 245: 100.00		TRI31_HUMAN (19-180): 1.72e-25: 104: 15.85
+	Mm
		1141429 MAVS_MOUSE (1-538): 5.1e-46: 170: 47.68		TRAF3_MOUSE (15-215): 1.66e-32: 125: 20.29
+	Mm
		936210 MAVS_MOUSE (1-538): 5.1e-46: 170: 47.68		TRAF5_MOUSE (12-215): 3.61e-30: 119: 20.10
+	Mm
		936265 MAVS_MOUSE (1-538): 5.1e-46: 170: 47.68		TRAF6_MOUSE (8-235): 1.28e-29: 117: 16.52
+	Mm
		1112453 MAVS_MOUSE (1-538): 5.1e-46: 170: 47.68		Q3UCL2_MOUSE (22-165): 1.18e-29: 116: 18.75
+	Mm
		761831 MAVS_MOUSE (1-538): 5.1e-46: 170: 47.68		TRAF2_MOUSE (15-186): 2.58e-25: 104: 20.11
+	Mm
		1112346 SC24A_MOUSE (93-490): 4.12e-17: 87.2: 16.71		TRAF3_MOUSE (15-215): 1.66e-32: 125: 20.29
+	Mm
		101444 F8VPR5_MOUSE (82-395): 1.45e-11: 69.8: 14.24		TRAF3_MOUSE (15-215): 1.66e-32: 125: 20.29
+	Hs
		585039 CIC_HUMAN (40-516): 7.01e-10: 64.1: 12.58		RO52_HUMAN (19-166): 8.73e-31: 120: 20.95
+	Hs
		551440 MDC1_HUMAN (105-516): 3.47e-10: 65.2: 10.48		RAG1_HUMAN (30-149): 1.21e-28: 115: 28.23
+	Hs
		1223389 CIC_HUMAN (40-516): 7.01e-10: 64.1: 12.58		TRI22_HUMAN (26-166): 4.86e-26: 107: 17.01