HitPredict

Interactor 1: MAVS (Q7Z434)
Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA)
Gene: MAVS

Interactor 2: RNF5 (Q99942)
E3 ubiquitin-protein ligase RNF5 (EC 2.3.2.27) (RING finger protein 5) (Ram1 homolog) (HsRma1)
Gene: RNF5

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.694

Property	Details
Experiments	35107381, 33577621, 20483786, 19285439
Identification Methods	affinity chromatography technology, pull down, enzymatic study, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0031966 - mitochondrial membrane
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 540 Hs			1 180
+	Hs
		1190082 MAVS_HUMAN (1-540): 1.73e-73: 245: 100.00		TRI31_HUMAN (19-126): 9.14e-27: 106: 20.91
+	Hs
		584997 MAVS_HUMAN (1-540): 1.73e-73: 245: 100.00		RO52_HUMAN (23-148): 9.12e-25: 101: 18.11
+	Hs
		1190083 MAVS_HUMAN (1-540): 1.73e-73: 245: 100.00		TRIM7_HUMAN (1-101): 4.17e-21: 91.3: 23.48
+	Hs
		1192169 HUWE1_HUMAN (79-539): 8.05e-24: 108: 13.36		RN185_HUMAN (17-179): 7.02e-52: 166: 60.98
+	Mm
		1112453 MAVS_MOUSE (1-538): 5.1e-46: 170: 47.68		Q3UCL2_MOUSE (23-165): 5.91e-24: 99: 14.58
+	Hs
		749630 HUWE1_HUMAN (79-539): 8.05e-24: 108: 13.36		BRCA1_HUMAN (25-76): 3.12e-19: 86.4: 34.62
+	Mm
		1186495 HUWE1_MOUSE (108-539): 1.87e-18: 91.8: 13.89		TRIM3_MOUSE (3-109): 1.57e-21: 92.5: 20.66
+	Hs
		585039 CIC_HUMAN (40-516): 7.01e-10: 64.1: 12.58		RO52_HUMAN (23-148): 9.12e-25: 101: 18.11
+	Hs
		1223389 CIC_HUMAN (40-516): 7.01e-10: 64.1: 12.58		TRI22_HUMAN (20-126): 2e-24: 100: 19.64
+	Hs
		1055155 CIC_HUMAN (40-516): 7.01e-10: 64.1: 12.58		HLTF_HUMAN (20-77): 5.99e-21: 90.9: 29.31
+	Hs
		749275 SC24C_HUMAN (116-429): 9.64e-11: 66.7: 15.43		BRCA1_HUMAN (25-76): 3.12e-19: 86.4: 34.62
+	Hs
		749499 MDC1_HUMAN (105-516): 3.47e-10: 65.2: 10.48		BRCA1_HUMAN (25-76): 3.12e-19: 86.4: 34.62