Protein: LIMC1
LIM and calponin homology domains-containing protein 1

Gene: LIMC1, LIMCH1
Organism: Homo sapiens
Interactions: 87
UniProt ID: Q9UPQ0

Gene Ontology (top 5):
GO:0001725 - stress fiber
GO:0001934 - positive regulation of protein phosphorylation
GO:0003779 - actin binding
GO:0005737 - cytoplasm
GO:0015629 - actin cytoskeleton

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

863033

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

2

High-throughput

0.691

High

1249993

LRIG3
Leucine-rich repeats and immunoglobulin-like domains protein 3

1

4

Small-scale

0.637

High

247464

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

9

High-throughput

0.618

High

896666

VASP
Vasodilator-stimulated phosphoprotein

1

2

High-throughput

0.618

High

953185

ACTB
Actin, cytoplasmic 1

1

19

High-throughput

0.618

High

1156246

ZYX
Zyxin

1

5

High-throughput

0.618

High

564568

CFTR
Cystic fibrosis transmembrane conductance regulator

2

11

High-throughput

0.601

High

1397887

KLH15
Kelch-like protein 15

3

2

High-throughput

0.599

High

583029

EZRI
Ezrin

2

6

High-throughput

0.584

High

397230

ESR1
Estrogen receptor

2

18

High-throughput

0.571

High

373507

MYC
Myc proto-oncogene protein

1

8

High-throughput

0.553

High

412817

NTRK1
High affinity nerve growth factor receptor

1

5

High-throughput

0.553

High

463261

YES
Tyrosine-protein kinase Yes

1

7

High-throughput

0.553

High

1394730

LRIG1
Leucine-rich repeats and immunoglobulin-like domains protein 1

1

4

Small-scale

0.553

High

630091

BTF3
Transcription factor BTF3

1

3

High-throughput

0.536

High

668074

CDK2
Cyclin-dependent kinase 2

1

11

High-throughput

0.536

High

773087

MYH9
Myosin-9

1

10

High-throughput

0.536

High

866873

CAZA2
F-actin-capping protein subunit alpha-2

1

5

High-throughput

0.536

High

877791

TNNI2
Troponin I, fast skeletal muscle

1

3

High-throughput

0.536

High

968487

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

4

High-throughput

0.536

High

1229156

FRPD2
FERM and PDZ domain-containing protein 2

1

10

High-throughput

0.536

High

1365620

MY18A
Unconventional myosin-XVIIIa

1

14

High-throughput

0.536

High

1392697

MYO19
Unconventional myosin-XIX

1

11

High-throughput

0.536

High

1399327

BIRC8
Baculoviral IAP repeat-containing protein 8

1

4

High-throughput

0.536

High

1447447

ANLN
Anillin

1

5

High-throughput

0.536

High

1462519

ST38L
Serine/threonine-protein kinase 38-like

1

10

High-throughput

0.536

High

1462520

MB212
Protein mab-21-like 2

1

2

High-throughput

0.536

High

1322398

ABRA
Actin-binding Rho-activating protein

1

0

High-throughput

0.513

High

423465

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.501

High

335345

M3K6
Mitogen-activated protein kinase kinase kinase 6

1

16

High-throughput

0.489

High

378446

IFNG
Interferon gamma

1

1

High-throughput

0.489

High

1289724

NAA40
N-alpha-acetyltransferase 40

1

3

High-throughput

0.489

High

1351799

SYTL5
Synaptotagmin-like protein 5

1

1

High-throughput

0.489

High

1439089

MAGE1
Melanoma-associated antigen E1

1

3

High-throughput

0.489

High

173558

XPO1
Exportin-1

1

3

High-throughput

0.479

High

401706

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

10

High-throughput

0.479

High

425680

ISG15
Ubiquitin-like protein ISG15

1

3

High-throughput

0.479

High

459805

PROF1
Profilin-1

1

3

High-throughput

0.479

High

520457

ANDR
Androgen receptor

1

17

High-throughput

0.479

High

556427

CADH1
Cadherin-1

1

10

High-throughput

0.479

High

765125

CTNB1
Catenin beta-1

1

4

High-throughput

0.479

High

1024933

VIGLN
Vigilin

1

6

High-throughput

0.479

High

1026593

HSF1
Heat shock factor protein 1

1

2

High-throughput

0.479

High

1049909

1433F
14-3-3 protein eta

1

20

High-throughput

0.479

High

1116137

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

14

High-throughput

0.479

High

1160800

DREB
Drebrin

1

6

High-throughput

0.479

High

1253249

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

6

High-throughput

0.479

High

1280606

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

7

Small-scale

0.479

High

1331580

CE120
Centrosomal protein of 120 kDa

1

20

High-throughput

0.479

High

1364697

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

9

High-throughput

0.479

High

1384306

SH3K1
SH3 domain-containing kinase-binding protein 1

1

3

High-throughput

0.479

High

1417102

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

6

High-throughput

0.479

High

1437758

GBB4
Guanine nucleotide-binding protein subunit beta-4

1

7

High-throughput

0.479

High

1458548

HDAC6
Protein deacetylase HDAC6

1

14

High-throughput

0.479

High

378207

TNFA
Tumor necrosis factor

1

0

High-throughput

0.458

High

664832

CCND1
G1/S-specific cyclin-D1

1

0

High-throughput

0.458

High

106862

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

278996

PEX14
Peroxisomal membrane protein PEX14

1

1

High-throughput

0.437

High

358832

LDHA
L-lactate dehydrogenase A chain

1

4

High-throughput

0.437

High

590041

RFA2
Replication protein A 32 kDa subunit

1

8

High-throughput

0.437

High

596425

H12
Histone H1.2

1

6

High-throughput

0.437

High

696871

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.437

High

769524

RFA3
Replication protein A 14 kDa subunit

1

8

High-throughput

0.437

High

769922

RFC2
Replication factor C subunit 2

1

3

High-throughput

0.437

High

939665

BID
BH3-interacting domain death agonist

1

1

Small-scale

0.437

High

1041713

TNAP2
Tumor necrosis factor alpha-induced protein 2

1

1

Small-scale

0.437

High

1086350

TFCP2
Alpha-globin transcription factor CP2

1

1

High-throughput

0.437

High

1138174

TNIP1
TNFAIP3-interacting protein 1

1

20

High-throughput

0.437

High

1203294

ODFP2
Outer dense fiber protein 2

1

19

High-throughput

0.437

High

1327274

FBXL6
F-box/LRR-repeat protein 6

1

1

High-throughput

0.437

High

1338437

FBX22
F-box only protein 22

1

1

High-throughput

0.437

High

1363894

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

2

High-throughput

0.437

High

1398526

ZDH15
Palmitoyltransferase ZDHHC15

1

1

Small-scale

0.437

High

1458934

ZO2
Tight junction protein 2

1

5

High-throughput

0.437

High

1460550

NAGK
N-acetyl-D-glucosamine kinase

1

1

High-throughput

0.437

High

1462518

SMAG1
Protein Smaug homolog 1

1

1

High-throughput

0.437

High

108052

G3V2R1
Sterile alpha motif domain containing 4A

1

1

High-throughput

0.407

High

766013

BMI1
Polycomb complex protein BMI-1

1

8

High-throughput

0.407

High

1235031

PKHA7
Pleckstrin homology domain-containing family A member 7

1

16

High-throughput

0.407

High

1405540

ZBT18
Zinc finger and BTB domain-containing protein 18

1

2

High-throughput

0.407

High

1461007

FBW1B
F-box/WD repeat-containing protein 11

1

7

High-throughput

0.407

High

1329498

OTU6B
Deubiquitinase OTUD6B

3

0

High-throughput

0.347

High

1333424

S43A3
Equilibrative nucleobase transporter 1

1

0

High-throughput

0.279

Low

1430463

MAGT1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1

1

0

High-throughput

0.269

Low

346784

CER1
Cerberus

1

0

High-throughput

0.232

Low

567228

PPA5
Tartrate-resistant acid phosphatase type 5

1

0

High-throughput

0.232

Low

1065042

FGL1
Fibrinogen-like protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025