HitPredict

Interactor 1: MAVS (Q7Z434)
Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA)
Gene: MAVS

Interactor 2: TRI31 (Q9BZY9)
E3 ubiquitin-protein ligase TRIM31 (EC 2.3.2.27) (Tripartite motif-containing protein 31)
Gene: TRIM31

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	0.60	0.713

Property	Details
Experiments	27992402, 32511263, 34016972, 31304625, 34239064
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0045087 - innate immune response GO:0051091 - positive regulation of DNA-binding transcription factor activity GO:0051607 - defense response to virus GO:0140374 - antiviral innate immune response
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 540 Hs			1 425
+	Hs
		584997 MAVS_HUMAN (1-540): 1.73e-73: 245: 100.00		RO52_HUMAN (1-378): 3.73e-97: 300: 23.81
+	Hs
		1190083 MAVS_HUMAN (1-540): 1.73e-73: 245: 100.00		TRIM7_HUMAN (11-378): 2.51e-85: 271: 20.65
+	Mm
		1112453 MAVS_MOUSE (1-538): 5.1e-46: 170: 47.68		Q3UCL2_MOUSE (6-378): 1.18e-87: 276: 22.25
+	Mm
		1246776 MAVS_MOUSE (1-538): 5.1e-46: 170: 47.68		TRI31_MOUSE (1-330): 4.24e-71: 234: 53.94
+	Hs
		585039 CIC_HUMAN (40-516): 7.01e-10: 64.1: 12.58		RO52_HUMAN (1-378): 3.73e-97: 300: 23.81
+	Hs
		537122 MAGL2_HUMAN (48-539): 3.46e-09: 61.8: 10.14		TRI27_HUMAN (1-378): 1.04e-92: 290: 23.56
+	Hs
		1223389 CIC_HUMAN (40-516): 7.01e-10: 64.1: 12.58		TRI22_HUMAN (1-377): 7.65e-82: 261: 22.31