HitPredict

Interactor 1: I2BP2 (Q7Z5L9)
Interferon regulatory factor 2-binding protein 2 (IRF-2-binding protein 2) (IRF-2BP2)
Gene: IRF2BP2

Interactor 2: I2BPL (Q9H1B7)
Probable E3 ubiquitin-protein ligase IRF2BPL (EC 2.3.2.27) (Enhanced at puberty protein 1) (Interferon regulatory factor 2-binding protein-like)
Gene: IRF2BPL

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	21444724, 26593974, 36652389
Identification Methods	affinity chromatography technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003714 - transcription corepressor activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0046872 - metal ion binding
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 587 Hs			1 796
+	Hs
		1215913 I2BP1_HUMAN (5-586): 1.02e-134: 407: 32.58		I2BPL_HUMAN (1-796): 4.29e-122: 387: 100.00
+	Hs
		1191125 I2BP2_HUMAN (1-587): 0: 697: 100.00		I2BP1_HUMAN (4-209): 1.68e-19: 95.3: 38.35
+	Hs
		1191122 I2BP2_HUMAN (1-587): 0: 697: 100.00		I2BP2_HUMAN (9-509): 3.36e-17: 88: 20.52
+	Hs
		1328578 I2BPL_HUMAN (4-346): 2.57e-88: 292: 38.48		I2BPL_HUMAN (1-796): 4.29e-122: 387: 100.00
+	Hs
		1215898 I2BP1_HUMAN (5-586): 1.02e-134: 407: 32.58		I2BP1_HUMAN (4-209): 1.68e-19: 95.3: 38.35
+	Ce
		70254 B2D6P5_CAEEL (1-99): 1.34e-27: 117: 50.51		B2D6P5_CAEEL (11-265): 2.93e-22: 102: 25.49
+	Ce
		954965 P92004_CAEEL (13-99): 1.93e-27: 117: 55.17		P92004_CAEEL (11-265): 3.97e-22: 102: 25.49