Protein: UBP15
Ubiquitin carboxyl-terminal hydrolase 15 (EC 3.4.19.12) (Deubiquitinating enzyme 15) (Ubiquitin thioesterase 15) (Ubiquitin-specific-processing protease 15)

Gene: UBP15
Organism: Saccharomyces cerevisiae S288C
Interactions: 152
UniProt ID: P50101

Gene Ontology (top 5):
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005777 - peroxisome
GO:0005783 - endoplasmic reticulum

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

509636

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

2

20

Small-scale

0.767

High

893283

2ABA
Protein phosphatase PP2A regulatory subunit B

2

0

High-throughput

0.736

High

893300

ECM30
Protein ECM30

8

0

Small-scale

0.715

High

740498

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

18

High-throughput

0.691

High

893279

CDH1
APC/C activator protein CDH1

4

20

Small-scale

0.689

High

796401

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

16

High-throughput

0.665

High

893311

NOP56
Nucleolar protein 56

1

4

High-throughput

0.665

High

817842

GLE2
mRNA export factor GLE2

1

11

High-throughput

0.618

High

893274

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

13

High-throughput

0.618

High

893296

SEC13
Protein transport protein SEC13

1

7

High-throughput

0.618

High

386781

TBB
Tubulin beta chain

2

15

High-throughput

0.611

High

453683

PYR1
Multifunctional protein URA2

2

4

High-throughput

0.611

High

574593

YAK1
Dual specificity protein kinase YAK1

2

14

Small-scale

0.611

High

762387

PEX5
Peroxisomal targeting signal receptor

2

9

Small-scale

0.602

High

871494

ASK10
Activator of SKN7 protein 10

2

1

High-throughput

0.601

High

893280

FPK1
Flippase kinase 1

2

13

Small-scale

0.584

High

394713

EF1A
Elongation factor 1-alpha

1

7

High-throughput

0.575

High

893277

SEH1
Nucleoporin SEH1

1

12

High-throughput

0.553

High

754540

PEX6
Peroxisomal ATPase PEX6

1

8

Small-scale

0.552

High

524523

HSP71
Heat shock protein SSA1

2

11

High-throughput

0.552

High

819236

SSB2
Ribosome-associated molecular chaperone SSB2

2

11

High-throughput

0.552

High

812249

YM11
Uncharacterized protein YMR124W

2

0

High-throughput

0.547

High

444568

DED1
ATP-dependent RNA helicase DED1

1

13

High-throughput

0.536

High

748872

SWE1
Mitosis inhibitor protein kinase SWE1

1

13

High-throughput

0.536

High

762986

SPT7
SAGA complex subunit SPT7

1

20

High-throughput

0.536

High

807242

SPT8
SAGA complex subunit SPT8

1

1

High-throughput

0.536

High

818021

LSM4
LSM complex subunit LSM4

1

1

High-throughput

0.536

High

850444

LSB3
LAS seventeen-binding protein 3

1

9

High-throughput

0.536

High

893281

CBK1
Serine/threonine-protein kinase CBK1

1

7

High-throughput

0.536

High

893302

PRP11
Pre-mRNA-splicing factor PRP11

1

1

High-throughput

0.536

High

893309

HSP42
Heat shock protein 42

1

2

High-throughput

0.536

High

623897

MYO2
Myosin-2

1

17

High-throughput

0.515

High

636471

ACE2
Metallothionein expression activator

1

16

High-throughput

0.515

High

737101

CDC11
Cell division control protein 11

1

2

High-throughput

0.515

High

751674

SEC3
Exocyst complex component SEC3

1

20

High-throughput

0.515

High

816523

SNU13
13 kDa ribonucleoprotein-associated protein

1

6

High-throughput

0.515

High

835509

BUB1
Spindle assembly checkpoint serine/threonine-protein kinase BUB1

1

7

High-throughput

0.515

High

843189

EMW1
Essential for maintenance of the cell wall protein 1

1

6

High-throughput

0.515

High

864474

MTR4
ATP-dependent RNA helicase DOB1

1

19

High-throughput

0.515

High

893276

ALAT2
Inactive alanine aminotransferase

1

3

High-throughput

0.515

High

893284

BCK1
Serine/threonine-protein kinase BCK1/SLK1/SSP31

1

5

High-throughput

0.515

High

893298

RGC1
Regulator of the glycerol channel 1

1

1

High-throughput

0.515

High

636935

FAR1
Cyclin-dependent kinase inhibitor FAR1

1

0

High-throughput

0.513

High

441189

KAPA
cAMP-dependent protein kinase type 1

1

7

High-throughput

0.501

High

602556

PHO85
Cyclin-dependent protein kinase PHO85

1

3

High-throughput

0.501

High

718949

CGS5
S-phase entry cyclin-5

1

2

Small-scale

0.501

High

750275

PRP40
Pre-mRNA-processing protein PRP40

1

1

High-throughput

0.501

High

793175

AKL1
Serine/threonine-protein kinase AKL1

1

1

High-throughput

0.501

High

822225

SECU
Securin

1

1

Small-scale

0.501

High

822259

DOA10
ERAD-associated E3 ubiquitin-protein ligase DOA10

1

5

High-throughput

0.501

High

850949

TOS3
Serine/threonine-protein kinase TOS3

1

4

High-throughput

0.501

High

866159

ENT3
Epsin-3

1

4

Small-scale

0.501

High

893292

SKY1
Serine/threonine-protein kinase SKY1

1

20

High-throughput

0.501

High

893293

ENT5
Epsin-5

1

4

Small-scale

0.501

High

893304

ESA1
Histone acetyltransferase ESA1

1

3

Small-scale

0.501

High

664318

SSD1
Protein SSD1

1

0

High-throughput

0.493

High

751551

DHE2
NAD-specific glutamate dehydrogenase

1

0

High-throughput

0.493

High

782266

DRE2
Fe-S cluster assembly protein DRE2

1

0

High-throughput

0.493

High

806852

MNL1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

0

High-throughput

0.493

High

858339

SAC3
Nuclear mRNA export protein SAC3

1

0

High-throughput

0.493

High

865980

YJ68
Uncharacterized protein YJR098C

1

0

High-throughput

0.493

High

402053

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

2

High-throughput

0.479

High

470558

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

2

High-throughput

0.479

High

486250

TBA1
Tubulin alpha-1 chain

1

12

High-throughput

0.479

High

486490

TBA3
Tubulin alpha-3 chain

1

13

High-throughput

0.479

High

564663

STE12
Protein STE12

1

1

Small-scale

0.479

High

577321

NSP1
Nucleoporin NSP1

1

13

High-throughput

0.479

High

579726

HSC82
ATP-dependent molecular chaperone HSC82

1

8

High-throughput

0.479

High

590673

HSP26
Heat shock protein 26

1

2

High-throughput

0.479

High

594462

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

2

High-throughput

0.479

High

663779

PEX1
Peroxisomal ATPase PEX1

1

9

Small-scale

0.479

High

679861

CDC48
Cell division control protein 48

1

7

High-throughput

0.479

High

707615

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

738486

NUP2
Nucleoporin NUP2

1

8

High-throughput

0.479

High

745807

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

7

High-throughput

0.479

High

756641

NIC96
Nucleoporin NIC96

1

1

High-throughput

0.479

High

764116

SPT21
Protein SPT21

1

1

High-throughput

0.479

High

776613

DEF1
RNA polymerase II degradation factor 1

1

5

High-throughput

0.479

High

779286

CENPA
Histone H3-like centromeric protein CSE4

1

9

High-throughput

0.479

High

792867

ANM1
Protein arginine N-methyltransferase 1

1

3

High-throughput

0.479

High

800664

KPR2
Ribose-phosphate pyrophosphokinase 2

1

5

High-throughput

0.479

High

803618

RPN1
26S proteasome regulatory subunit RPN1

1

5

High-throughput

0.479

High

807107

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

3

High-throughput

0.479

High

811271

RGA1
Rho-type GTPase-activating protein 1

1

4

High-throughput

0.479

High

812478

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.479

High

825164

NU159
Nucleoporin NUP159

1

13

High-throughput

0.479

High

864637

NU192
Nucleoporin NUP192

1

1

High-throughput

0.479

High

874244

CLA4
Serine/threonine-protein kinase CLA4

1

10

Small-scale

0.479

High

886192

NU145
Nucleoporin NUP145

1

14

High-throughput

0.479

High

893282

APJ1
J domain-containing protein APJ1

1

9

High-throughput

0.479

High

893285

NUP49
Nucleoporin NUP49/NSP49

1

7

High-throughput

0.479

High

893287

NU116
Nucleoporin NUP116/NSP116

1

13

High-throughput

0.479

High

893288

ROD1
Protein ROD1

1

1

Small-scale

0.479

High

893289

IMA1
Importin subunit alpha

1

6

High-throughput

0.479

High

893290

DIG1
Down-regulator of invasive growth 1

1

1

Small-scale

0.479

High

893299

IMB1
Importin subunit beta-1

1

2

High-throughput

0.479

High

893305

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

2

High-throughput

0.479

High

893308

GLE1
mRNA export factor GLE1

1

2

High-throughput

0.479

High

642153

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

1

High-throughput

0.470

High

866230

IML1
Vacuolar membrane-associated protein IML1

1

4

High-throughput

0.470

High

871029

NOL10
Ribosome biogenesis protein ENP2

1

1

High-throughput

0.470

High

893278

MLC1
Myosin light chain 1

1

6

High-throughput

0.470

High

603079

EST1
Telomere elongation protein EST1

1

0

High-throughput

0.458

High

613827

TEC1
Ty transcription activator TEC1

1

0

Small-scale

0.458

High

732034

MLF3
Protein MLF3

1

0

Small-scale

0.458

High

744086

PMD1
Negative regulator of sporulation PMD1

1

0

Small-scale

0.458

High

747947

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

757337

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

0

High-throughput

0.458

High

758180

LST4
Protein LST4

1

0

Small-scale

0.458

High

782541

NU133
Nucleoporin NUP133

1

0

High-throughput

0.458

High

794819

ECM21
Protein ECM21

1

0

Small-scale

0.458

High

805260

SBE22
Protein SBE22

1

0

Small-scale

0.458

High

805776

YHT1
PH domain-containing protein YHR131C

1

0

High-throughput

0.458

High

808859

UME6
Transcriptional regulatory protein UME6

1

0

High-throughput

0.458

High

823484

NUP82
Nucleoporin NUP82

1

0

High-throughput

0.458

High

826651

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

893291

DIG2
Down-regulator of invasive growth 2

1

0

Small-scale

0.458

High

893303

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.458

High

893312

HPH1
Protein HPH1

1

0

Small-scale

0.458

High

393019

HSP82
ATP-dependent molecular chaperone HSP82

1

8

High-throughput

0.445

High

510646

HSP77
Import motor subunit, mitochondrial

1

15

High-throughput

0.445

High

527145

HSP72
Heat shock protein SSA2

1

11

High-throughput

0.445

High

545521

SSB1
Ribosome-associated molecular chaperone SSB1

1

11

High-throughput

0.445

High

592361

VATB
V-type proton ATPase subunit B

1

6

High-throughput

0.445

High

639038

VPS1
Vacuolar protein sorting-associated protein 1

1

3

High-throughput

0.445

High

670918

SIS1
Protein SIS1

1

7

High-throughput

0.445

High

742896

HSP79
Heat shock protein homolog SSE2

1

15

High-throughput

0.445

High

752494

HSP78
Heat shock protein 78, mitochondrial

1

2

High-throughput

0.445

High

823275

JEM1
DnaJ-like chaperone JEM1

1

6

High-throughput

0.445

High

844414

TCPH
T-complex protein 1 subunit eta

1

16

High-throughput

0.445

High

858546

AP3B
AP-3 complex subunit beta

1

7

High-throughput

0.445

High

863647

PFD1
Prefoldin subunit 1

1

1

High-throughput

0.445

High

885021

RL4B
Large ribosomal subunit protein uL4B

1

2

High-throughput

0.445

High

893301

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

6

High-throughput

0.445

High

893307

RL7B
Large ribosomal subunit protein uL30B

1

4

High-throughput

0.445

High

661662

MPCP
Mitochondrial phosphate carrier protein

1

5

High-throughput

0.437

High

757665

IF4B
Eukaryotic translation initiation factor 4B

1

6

High-throughput

0.437

High

795095

NU170
Nucleoporin NUP170

1

1

High-throughput

0.437

High

877960

NUP57
Nucleoporin NUP57

1

8

High-throughput

0.437

High

893286

NU100
Nucleoporin NUP100/NSP100

1

13

High-throughput

0.437

High

893294

NUP53
Nucleoporin NUP53

1

1

High-throughput

0.437

High

893297

NUP59
Nucleoporin ASM4

1

1

High-throughput

0.437

High

893306

ATG9
Autophagy-related protein 9

1

1

High-throughput

0.437

High

893310

DBP10
ATP-dependent RNA helicase DBP10

1

19

High-throughput

0.437

High

754372

PAD1
Flavin prenyltransferase PAD1, mitochondrial

1

0

High-throughput

0.269

Low

795687

YBE4
Uncharacterized protein YBL044W

1

0

High-throughput

0.269

Low

776531

NU120
Nucleoporin NUP120

1

0

High-throughput

0.249

Low

795676

RRT1
Regulator of rDNA transcription protein 1

1

0

High-throughput

0.249

Low

858311

NUP85
Nucleoporin NUP85

1

0

High-throughput

0.249

Low

893275

NU188
Nucleoporin NUP188

1

0

High-throughput

0.249

Low

893295

YM35
Uncharacterized protein YMR160W

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025