HitPredict

Interactor 1: RBBP6 (Q7Z6E9)
E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis)
Gene: RBBP6

Interactor 2: EZH1 (Q92800)
Histone-lysine N-methyltransferase EZH1 (EC 2.1.1.356) (ENX-2) (Enhancer of zeste homolog 1)
Gene: EZH1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1792 Hs			1 747
+	Hs
		1080080 RBBP6_HUMAN (1-1792): 1.97e-152: 516: 100.00		EZH2_HUMAN (8-746): 0: 719: 62.78
+	Hs
		1080261 MINT_HUMAN (76-1784): 4.28e-28: 126: 7.98		EZH2_HUMAN (8-746): 0: 719: 62.78
+	Hs
		1080130 BD1L1_HUMAN (851-1782): 4.77e-20: 100: 13.46		EZH2_HUMAN (8-746): 0: 719: 62.78
+	Hs
		1080127 KMT2C_HUMAN (88-1775): 2.2e-16: 88.1: 7.78		EZH2_HUMAN (8-746): 0: 719: 62.78
+	Hs
		1080172 ELYS_HUMAN (577-1779): 2.2e-15: 84.9: 12.70		EZH2_HUMAN (8-746): 0: 719: 62.78
+	Hs
		1080524 PRC2C_HUMAN (87-1452): 1.6e-12: 75.4: 8.27		EZH2_HUMAN (8-746): 0: 719: 62.78
+	Hs
		1056971 MDC1_HUMAN (508-1516): 4.61e-24: 113: 10.37		SETD2_HUMAN (181-733): 3.89e-76: 271: 14.90
+	Hs
		331812 MDC1_HUMAN (508-1516): 4.61e-24: 113: 10.37		NSD2_HUMAN (471-730): 3.64e-61: 225: 24.09
+	Hs
		1056940 MDC1_HUMAN (508-1516): 4.61e-24: 113: 10.37		NSD1_HUMAN (472-730): 1.84e-55: 208: 23.55
+	Hs
		1244240 BD1L1_HUMAN (851-1782): 4.77e-20: 100: 13.46		NSD3_HUMAN (556-728): 3.08e-53: 201: 32.78
+	Dm
		1129083 Q9VLS7_DROME (382-1689): 4.6e-21: 103: 7.43		SET1_DROME (612-733): 3.98e-19: 94.7: 39.52
+	Hs
		975287 BD1L1_HUMAN (851-1782): 4.77e-20: 100: 13.46		KMT2A_HUMAN (620-734): 4.36e-19: 95.1: 42.24
+	Hs
		1244253 BD1L1_HUMAN (851-1782): 4.77e-20: 100: 13.46		SET1B_HUMAN (620-733): 4.68e-19: 94.7: 41.38
+	Hs
		165700 BD1L1_HUMAN (851-1782): 4.77e-20: 100: 13.46		SET1A_HUMAN (612-733): 1.12e-18: 93.6: 39.52
+	Hs
		975285 KMT2C_HUMAN (88-1775): 2.2e-16: 88.1: 7.78		KMT2A_HUMAN (620-734): 4.36e-19: 95.1: 42.24
+	Hs
		1243853 KMT2C_HUMAN (88-1775): 2.2e-16: 88.1: 7.78		SET1B_HUMAN (620-733): 4.68e-19: 94.7: 41.38
+	Hs
		165699 KMT2C_HUMAN (88-1775): 2.2e-16: 88.1: 7.78		SET1A_HUMAN (612-733): 1.12e-18: 93.6: 39.52
+	Hs
		975294 TITIN_HUMAN (79-1153): 3.14e-15: 84.6: 10.07		KMT2A_HUMAN (620-734): 4.36e-19: 95.1: 42.24
+	Dm
		54311 A1Z9J3_DROME (946-1383): 2.53e-11: 71.5: 15.33		SET1_DROME (612-733): 3.98e-19: 94.7: 39.52