Protein: PDI
Protein disulfide-isomerase (PDI) (dPDI) (EC 5.3.4.1)

Gene: PDI
Organism: Drosophila melanogaster
Interactions: 222
UniProt ID: P54399

Gene Ontology (top 5):
GO:0003756 - protein disulfide isomerase activity
GO:0005615 - extracellular space
GO:0005635 - nuclear envelope
GO:0005737 - cytoplasm
GO:0005783 - endoplasmic reticulum

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

712329

CALR
Calreticulin

2

20

High-throughput

0.737

High

929467

TRXR1
Thioredoxin reductase 1, mitochondrial

2

8

High-throughput

0.737

High

929479

Q3YMU0
Protein disulfide-isomerase

2

16

High-throughput

0.737

High

929528

PDIA6
Protein disulfide-isomerase A6 homolog

2

17

High-throughput

0.737

High

929555

Q9VHA8
LD25575p

2

20

High-throughput

0.737

High

929484

Q7JX87
1-Cys peroxiredoxin

2

15

High-throughput

0.659

High

929527

THIO2
Thioredoxin-2

2

18

High-throughput

0.659

High

263671

O61604
Fimbrin

1

7

High-throughput

0.618

High

929501

Q8IRH7
Supercoiling factor variant B

1

18

High-throughput

0.618

High

929531

Q9VA69
procollagen-proline 4-dioxygenase

1

11

High-throughput

0.618

High

929465

CALM
Calmodulin

1

2

High-throughput

0.575

High

929519

Q9I7K7
Arrestin C-terminal-like domain-containing protein

1

4

High-throughput

0.575

High

929535

Q9VAL7
Calnexin 99A, isoform A

1

20

High-throughput

0.575

High

929614

Q9W0H8
Reticulocalbin-3

1

18

High-throughput

0.575

High

57533

A1ZB71
Glutathione S transferase E6

2

5

High-throughput

0.571

High

195014

O16043
Anon1A4

2

2

High-throughput

0.571

High

357479

INO1
Inositol-3-phosphate synthase

2

2

High-throughput

0.571

High

578052

ENO
Enolase

2

3

High-throughput

0.571

High

609372

PCNA
Proliferating cell nuclear antigen

2

3

High-throughput

0.571

High

649016

ANX10
Annexin B10

2

5

High-throughput

0.571

High

682719

PROF
Profilin

2

3

High-throughput

0.571

High

762523

UCHL
Ubiquitin carboxyl-terminal hydrolase

2

8

High-throughput

0.571

High

855979

MOEH
Moesin/ezrin/radixin homolog 1

2

6

High-throughput

0.571

High

871600

FKB12
Peptidyl-prolyl cis-trans isomerase Fkbp12

2

16

High-throughput

0.571

High

929464

SODC
Superoxide dismutase [Cu-Zn]

2

5

High-throughput

0.571

High

929468

1433E
14-3-3 protein epsilon

2

4

High-throughput

0.571

High

929478

NLP
Nucleoplasmin-like protein

2

6

High-throughput

0.571

High

929492

TERA
Transitional endoplasmic reticulum ATPase TER94

2

10

High-throughput

0.571

High

929500

Q8IRD3
Glutathione peroxidase

2

5

High-throughput

0.571

High

929505

Q8STA5
Histidine triad nucleotide binding protein 1, isoform A

2

2

High-throughput

0.571

High

929509

NACA
Nascent polypeptide-associated complex subunit alpha

2

4

High-throughput

0.571

High

929516

IF5A
Eukaryotic translation initiation factor 5A

2

4

High-throughput

0.571

High

929521

SH3BG
SH3 domain-binding glutamic acid-rich protein homolog

2

2

High-throughput

0.571

High

929524

Q9V3V2
peptidylprolyl isomerase

2

16

High-throughput

0.571

High

929537

Q9VAY2
Heat shock protein 83

2

8

High-throughput

0.571

High

929546

Q9VEB1
Malate dehydrogenase, mitochondrial

2

5

High-throughput

0.571

High

929551

Q9VGK3
peptidylprolyl isomerase

2

17

High-throughput

0.571

High

929553

TCTP
Translationally-controlled tumor protein homolog

2

2

High-throughput

0.571

High

929554

TEBPH
Cytosolic Prostaglandin E synthase

2

3

High-throughput

0.571

High

929576

Q9VPN5
Stress-induced-phosphoprotein 1

2

15

High-throughput

0.571

High

929577

Q9VPX6
Adenylyl cyclase-associated protein

2

2

High-throughput

0.571

High

929583

Q9VRD6
NTF2-related export protein

2

2

High-throughput

0.571

High

929588

Q9VSL2
Glutathione S transferase O3

2

5

High-throughput

0.571

High

929618

Q9W227
Peptidyl-prolyl cis-trans isomerase

2

16

High-throughput

0.571

High

726321

VATB
V-type proton ATPase subunit B

2

4

High-throughput

0.562

High

929627

OFUT2
GDP-fucose protein O-fucosyltransferase 2

2

0

High-throughput

0.547

High

756736

FAS2
Fasciclin-2

1

2

High-throughput

0.536

High

197742

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

2

3

High-throughput

0.521

High

356316

O97102
Small ubiquitin-related modifier

2

5

High-throughput

0.521

High

476918

NDKA
Nucleoside diphosphate kinase

2

4

High-throughput

0.521

High

652731

PSA71
Proteasome subunit alpha type-7-1

2

3

High-throughput

0.521

High

663954

PHB1
Prohibitin 1

2

4

High-throughput

0.521

High

835128

6PGD
6-phosphogluconate dehydrogenase, decarboxylating

2

1

High-throughput

0.521

High

929471

HMGD
High mobility group protein D

2

4

High-throughput

0.521

High

929472

ATPB
ATP synthase subunit beta, mitochondrial

2

4

High-throughput

0.521

High

929489

Q7K2K2
FI04612p

2

2

High-throughput

0.521

High

929536

Q9VAN7
Phosphoglycerate mutase

2

7

High-throughput

0.521

High

929557

Q9VHN7
transketolase

2

4

High-throughput

0.521

High

929563

EF1D
Probable elongation factor 1-delta

2

4

High-throughput

0.521

High

929564

Q9VL68
Enoyl-CoA delta isomerase 1, mitochondrial

2

3

High-throughput

0.521

High

929579

BACC
Bacchus

2

2

High-throughput

0.521

High

929592

Q9VTY2
Uncharacterized protein, isoform A

2

14

High-throughput

0.521

High

929593

Q9VU35
10 kDa heat shock protein, mitochondrial

2

6

High-throughput

0.521

High

929601

Q9VW59
Rho GDP-dissociation inhibitor 3

2

2

High-throughput

0.521

High

929631

PSA6
Proteasome subunit alpha type-6

2

8

High-throughput

0.521

High

53984

A1Z892
1-Cys peroxiredoxin

1

15

High-throughput

0.514

High

929600

Q9VVL7
Dihydrolipoyl dehydrogenase

1

8

High-throughput

0.514

High

929613

Q9W022
GEO01508p1

1

19

High-throughput

0.514

High

194931

MBL
Protein muscleblind

1

0

High-throughput

0.486

High

85785

B8A405
Ferritin

1

2

High-throughput

0.479

High

146102

CH60A
Heat shock protein 60A

1

1

High-throughput

0.479

High

929473

UGGG
UDP-glucose:glycoprotein glucosyltransferase

1

7

High-throughput

0.479

High

929487

SEELE
Protein seele

1

2

High-throughput

0.479

High

929496

Q86BM5
A kinase anchor protein 200, isoform D

1

6

High-throughput

0.479

High

929513

Q95SR0
Aminopeptidase

1

3

High-throughput

0.479

High

929595

PYRG
CTP synthase

1

2

High-throughput

0.479

High

929611

Q9VYR1
Regucalcin

1

4

High-throughput

0.479

High

929615

Q9W0M4
Endoplasmic reticulum transmembrane protein

1

8

High-throughput

0.479

High

929608

Q9VY48
Large ribosomal subunit protein mL38

1

5

High-throughput

0.464

High

304949

CRY1
Cryptochrome-1

1

0

High-throughput

0.458

High

929475

C5210
Imaginal disk growth factor 6

1

0

High-throughput

0.458

High

57756

A1ZB77
Uncharacterized protein, isoform J

1

2

High-throughput

0.445

High

86466

B9EQV3
Endoplasmic reticulum transmembrane protein

1

8

High-throughput

0.445

High

121197

ALDR
Aldo-keto reductase 1B

1

14

High-throughput

0.445

High

262659

LOK
Ovarian-specific serine/threonine-protein kinase Lok

1

2

High-throughput

0.445

High

304606

RS21
Small ribosomal subunit protein eS21

1

2

High-throughput

0.445

High

305642

IPYR
Inorganic pyrophosphatase

1

2

High-throughput

0.445

High

556651

PSA1
Proteasome subunit alpha type-1

1

3

High-throughput

0.445

High

648870

ANXB9
Annexin B9

1

5

High-throughput

0.445

High

668105

PPIA
Peptidyl-prolyl cis-trans isomerase

1

9

High-throughput

0.445

High

929482

Q76NR6
Regucalcin

1

4

High-throughput

0.445

High

929491

Q7K3J0
T-complex protein 1 subunit theta

1

1

High-throughput

0.445

High

929493

Q7KN99
Phosphopantothenoylcysteine synthetase, isoform A

1

2

High-throughput

0.445

High

929494

FRIH
Ferritin heavy chain

1

2

High-throughput

0.445

High

929495

Q7KTW5
Inositol-1-monophosphatase

1

2

High-throughput

0.445

High

929499

Q8IQZ7
FI19014p1

1

7

High-throughput

0.445

High

929504

Q8MYY7
RE44624p

1

10

High-throughput

0.445

High

929506

OLA1
Obg-like ATPase 1

1

2

High-throughput

0.445

High

929508

Q8T0L3
E1 ubiquitin-activating enzyme

1

2

High-throughput

0.445

High

929512

FAXC
Failed axon connections

1

2

High-throughput

0.445

High

929518

NASP
Nuclear autoantigenic sperm protein homolog

1

2

High-throughput

0.445

High

929520

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

2

High-throughput

0.445

High

929522

CP2B
Cardio acceleratory peptide 2b

1

1

High-throughput

0.445

High

929523

Q9V3I1
Deoxyuridine 5'-triphosphate nucleotidohydrolase

1

2

High-throughput

0.445

High

929533

Q9VAC4
GEO09167p1

1

6

High-throughput

0.445

High

929544

NAA25
Phagocyte signaling-impaired protein

1

7

High-throughput

0.445

High

929561

Q9VKB0
threonine--tRNA ligase

1

3

High-throughput

0.445

High

929566

FKB59
FK506-binding protein 59

1

12

High-throughput

0.445

High

929568

AK200
A-kinase anchor protein 200

1

9

High-throughput

0.445

High

929594

Q9VUC1
Hsc70Cb, isoform A

1

10

High-throughput

0.445

High

929599

Y9705
Cold shock domain-containing protein CG9705

1

2

High-throughput

0.445

High

929602

Q9VW70
FI21813p1

1

3

High-throughput

0.445

High

929609

CLIC
Chloride intracellular channel Clic

1

5

High-throughput

0.445

High

929616

SND1
Staphylococcal nuclease domain-containing protein 1

1

8

High-throughput

0.445

High

929621

Q9W3Y3
Calcyclin-binding protein

1

2

High-throughput

0.445

High

929624

Q9W457
Serine hydroxymethyltransferase

1

3

High-throughput

0.445

High

929625

Q9W475
LP17541p

1

6

High-throughput

0.445

High

929626

Q9W478
RE43153p

1

6

High-throughput

0.445

High

929629

Q9XYZ9
Glutathione S transferase E12, isoform A

1

6

High-throughput

0.445

High

929630

Q9XZ57
Eb1, isoform E

1

2

High-throughput

0.445

High

929632

PURA
Adenylosuccinate synthetase

1

2

High-throughput

0.445

High

356537

O97121
cystathionine gamma-lyase

1

0

High-throughput

0.438

High

120756

M9PE30
Transgelin

1

7

High-throughput

0.437

High

929481

Q6NPB4
SD15476p

1

2

High-throughput

0.437

High

929502

Q8IRS7
Ciboulot, isoform C

1

3

High-throughput

0.437

High

929552

Q9VGM2
Fatty acid-binding protein, muscle

1

4

High-throughput

0.437

High

929604

Q9VWP1
Ubiquitin carboxyl-terminal hydrolase 39

1

3

High-throughput

0.437

High

929619

Q9W3C3
LD10016p

1

2

High-throughput

0.437

High

234550

VINC
Vinculin

1

0

High-throughput

0.426

High

929545

Q9VEA1
Eukaryotic translation initiation factor 4C

1

0

High-throughput

0.426

High

929556

Q9VHL2
T-complex protein 1 subunit eta

1

0

High-throughput

0.426

High

929581

Q9VR95
Odorant-binding protein 19b

1

0

High-throughput

0.426

High

929591

Q9VTX2
RE32936p

1

0

High-throughput

0.426

High

95703

E4NKJ7
Peptidyl-prolyl cis-trans isomerase

1

16

High-throughput

0.417

High

929617

TALDO
Probable transaldolase

1

1

High-throughput

0.417

High

68378

A8DYR2
Smoke alarm, isoform C

1

3

High-throughput

0.407

High

305181

TRMB
tRNA

1

2

High-throughput

0.407

High

357268

O97428
Ciboulot, isoform A

1

3

High-throughput

0.407

High

458088

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

2

High-throughput

0.407

High

460012

ALF
Fructose-bisphosphate aldolase

1

2

High-throughput

0.407

High

626992

RLA0
Large ribosomal subunit protein uL10

1

1

High-throughput

0.407

High

821824

PSA2
Proteasome subunit alpha type-2

1

3

High-throughput

0.407

High

822038

PSB1
Proteasome subunit beta type-1

1

6

High-throughput

0.407

High

874631

RIR2
Ribonucleoside-diphosphate reductase subunit M2

1

2

High-throughput

0.407

High

928942

DOD
Putative peptidyl-prolyl cis-trans isomerase dodo

1

2

High-throughput

0.407

High

929463

VATE
V-type proton ATPase subunit E

1

2

High-throughput

0.407

High

929469

SODM
Superoxide dismutase [Mn], mitochondrial

1

1

High-throughput

0.407

High

929470

PGK
Phosphoglycerate kinase

1

5

High-throughput

0.407

High

929474

Q0KHZ6
Electron transfer flavoprotein subunit beta

1

2

High-throughput

0.407

High

929476

ATP5H
ATP synthase subunit d, mitochondrial

1

2

High-throughput

0.407

High

929483

Q7JVH6
LD24696p

1

14

High-throughput

0.407

High

929485

Q7JXC4
CG6459 protein

1

3

High-throughput

0.407

High

929488

Q7K148
Proteasome subunit beta

1

2

High-throughput

0.407

High

929497

QPCT2
Glutaminyl-peptide cyclotransferase

1

4

High-throughput

0.407

High

929498

Q8INK3
Fatty acid-binding protein, muscle

1

4

High-throughput

0.407

High

929503

Q8MT58
Carnosine dipeptidase 2, isoform A

1

3

High-throughput

0.407

High

929510

ACPM
Acyl carrier protein, mitochondrial

1

3

High-throughput

0.407

High

929514

Q95TZ4
Citrate synthase

1

3

High-throughput

0.407

High

929515

Q961E7
phosphorylase kinase

1

1

High-throughput

0.407

High

929517

JUPIT
Microtubule-associated protein Jupiter

1

2

High-throughput

0.407

High

929525

SPC25
Kinetochore protein Spc25

1

1

High-throughput

0.407

High

929526

Q9V3V9
Endonuclease G inhibitor, isoform A

1

2

High-throughput

0.407

High

929529

PSA3
Proteasome subunit alpha type-3

1

7

High-throughput

0.407

High

929530

Q9V9U3
LD45254p

1

3

High-throughput

0.407

High

929532

Q9VAC1
GM14349p

1

2

High-throughput

0.407

High

929534

Q9VAG3
trypsin

1

2

High-throughput

0.407

High

929538

Q9VBR6
RE74917p

1

7

High-throughput

0.407

High

929539

Q9VBT1
CHK kinase-like domain-containing protein

1

2

High-throughput

0.407

High

929541

Q9VCK6
LD34157p

1

2

High-throughput

0.407

High

929542

Q9VD02
GH14779p

1

5

High-throughput

0.407

High

929543

Q9VD29
small monomeric GTPase

1

8

High-throughput

0.407

High

929547

FLNA
Filamin-A

1

10

High-throughput

0.407

High

929549

Q9VG33
Sulfurtransferase

1

1

High-throughput

0.407

High

929558

Q9VHX4
LD24679p

1

14

High-throughput

0.407

High

929559

Q9VIC3
carboxylesterase

1

1

High-throughput

0.407

High

929560

Q9VIE8
Aconitate hydratase, mitochondrial

1

3

High-throughput

0.407

High

929562

Q9VKW5
Prolyl endopeptidase

1

8

High-throughput

0.407

High

929565

Q9VL70
HL08109p

1

2

High-throughput

0.407

High

929567

Q9VLB7
Rab GDP dissociation inhibitor

1

2

High-throughput

0.407

High

929569

Q9VMU6
LD31822p

1

4

High-throughput

0.407

High

929571

Q9VMZ9
RE36666p

1

2

High-throughput

0.407

High

929572

PSB4
Proteasome subunit beta type-4

1

8

High-throughput

0.407

High

929573

Q9VNB2
RE42193p

1

2

High-throughput

0.407

High

929574

Q9VNI5
LD10772p

1

5

High-throughput

0.407

High

929575

Q9VP52
GH24315p

1

1

High-throughput

0.407

High

929584

Q9VRL1
GEO06356p1

1

3

High-throughput

0.407

High

929585

Q9VRP2
Uncharacterized protein, isoform A

1

4

High-throughput

0.407

High

929587

Q9VSI6
Isocitrate dehydrogenase [NADP]

1

2

High-throughput

0.407

High

929597

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

1

2

High-throughput

0.407

High

929603

RS10B
Small ribosomal subunit protein eS10B

1

2

High-throughput

0.407

High

929605

DHB4
Peroxisomal multifunctional enzyme type 2

1

2

High-throughput

0.407

High

929606

Q9VXQ3
Diphosphomevalonate decarboxylase

1

1

High-throughput

0.407

High

929612

Q9VZI1
Transgelin

1

7

High-throughput

0.407

High

929620

Q9W3X6
fumarate hydratase

1

2

High-throughput

0.407

High

929622

CISY
Probable citrate synthase, mitochondrial

1

3

High-throughput

0.407

High

929623

WUHO
tRNA

1

11

High-throughput

0.407

High

929628

PSB3
Proteasome subunit beta type-3

1

6

High-throughput

0.407

High

929633

Q9Y112
BcDNA.GH10614

1

14

High-throughput

0.407

High

929490

Q7K2W2
GH04548p

2

0

High-throughput

0.298

High

929511

VDAC
Voltage-dependent anion-selective channel

2

0

High-throughput

0.298

High

929596

Q9VUL4
GH11627p

2

0

High-throughput

0.298

High

929589

Q9VSY9
Nuclear transcription factor Y subunit

1

0

High-throughput

0.265

Low

929590

Q9VTH8
Uncharacterized protein, isoform A

1

0

High-throughput

0.253

Low

929477

EWG
DNA-binding protein Ewg

1

0

High-throughput

0.251

Low

929598

Q9VV55
GH08429p

1

0

High-throughput

0.249

Low

53839

A1Z864
FI01421p

1

0

High-throughput

0.232

Low

84776

B7Z0I0
Gustatory receptor

1

0

High-throughput

0.232

Low

426650

HP1
Heterochromatin protein 1

1

0

High-throughput

0.232

Low

929466

CYC2
Cytochrome c-2

1

0

High-throughput

0.232

Low

929480

Q4LDP4
Testis-specific gamma-tubulin ring protein 91

1

0

High-throughput

0.232

Low

929486

Q7JXE1
Bunker gear

1

0

High-throughput

0.232

Low

929507

CAPON
Capon-like protein

1

0

High-throughput

0.232

Low

929540

ORN
Probable oligoribonuclease

1

0

High-throughput

0.232

Low

929548

Q9VG31
Malic enzyme

1

0

High-throughput

0.232

Low

929550

CLCN2
Chloride channel protein 2

1

0

High-throughput

0.232

Low

929570

GUAD
Guanine deaminase

1

0

High-throughput

0.232

Low

929578

Q9VQ61
Aspartate aminotransferase

1

0

High-throughput

0.232

Low

929580

Q9VR69
Chitin deacetylase-like 4

1

0

High-throughput

0.232

Low

929582

Q9VRD4
Uncharacterized protein, isoform A

1

0

High-throughput

0.232

Low

929586

Q9VS98
LD12639p

1

0

High-throughput

0.232

Low

929607

RT25
Small ribosomal subunit protein mS25

1

0

High-throughput

0.232

Low

929610

Q9VYB9
LP02557p

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025